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  • Kaspaze = Caspases
    Pižem, Jože ; Cör, Andrej
    Caspases are cysteine proteases, which cleave their substrates following an aspartate residue. They are present as inactive precursors (pro-caspases) in cells. Caspases are involved in cytokine ... processing and apoptosis (programmed cell death) regulation. Apoptotic caspases are activator caspases (caspases 8 and 9) or effector caspases (caspases 3 and 7). Apoptosis can be initiated by either extracellular or intracellular pathways. Extracellular signals mediate apoptosis by death receptors, which activate caspase 8. Intracellular signals provoke changes in the permeability of the outer mitochondrial membrane which permits cytochrome C release from mitochondria. In the cytosol, cytochrome C allows activation of caspase 9. Activated caspases 8 and/or 9 induce cascade activation of effector caspases which cleave different target proteins. Demolition of target proteins plays an important role in morphological changesof apoptotic cells.
    Source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 40, št. 3, sep. 2001, str. 283-291)
    Type of material - article, component part
    Publish date - 2001
    Language - slovenian
    COBISS.SI-ID - 14497497

    Link(s):

    Digitalna knjižnica Slovenije - dLib.si

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