Vloga bakterije Porphyromonas gingivalis na razvoj vnetja pljuč pri miših = The role of Porphyromonas gingivalis in pathogenesis of pulmonary inflammation in mice
Petelin, Milan
Background: The anaerobic bacterium Porphyromonas gingivalis accounts for a high percentage of microorganisms present in periodontal pockets of patients with advanced periodontal disease. Several ...studies have documented that nursing home subjects have an increased risk for aspiration pneumonia caused by oral pathogens. Materials and Methods: Pulmonary inflammation in mice was produced by intratracheal inoculation with the extract of Porphyromonas gingivalis. The local and systemic response to the inflammation was studied byhistological examination of lung tissue and measurement of the levels of TNF-alpha and soluble TNF receptors in serum and lungs. Results: A day after inoculation, neutrophil infiltration was visible mainly in peribronchial areas. Three days later, neutrophils were present in most alveoli but there was no evidence of pulmonary parenchymal necrosis. Two hours after inoculation, TNF-alpha increased in lung tissue but remained undetectable in serum. The level of soluble TNF-2 receptor in lung tissue increased appreciably a day after inoculation and remained elevated for three days. On day 7 following inoculation, the histological appearance of lung tissue was back to normal and the levels of TNF-alpha and soluble TNF-2 receptor returnedto normal values. Conclusion: Soluble TNF-2 receptor seems to play a key role in reducing the levels of TNF-alpha in the inflamed lung and thereby prevents its elevation in blood.
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