-
Development of pH responsive polysaccharide based wound dressings : doctoral disertationElveren, BesteIn the scope of the Doctoral Dissertation, a polysaccharide based stimuli-responsive smart material with controlled drug release was developed by using electrospinning technique, which allowed to ... form stimuli-responsive nanofibers with rapid visual detection of pH change in the wound bed along with anti-inflammatory activity. Incorporation of halochromic dyes into electrospun nanofibers has been an intriguing area for wound healing applications. Furthermore, it is known that the pH value within the wound milieu directly and indirectly influences all biochemical reactions taking place in the process of wound healing. It has been proven that the surface pH of a wound plays an important role in wound healing as it helps control infection and increases the antimicrobial activity, oxygen release, angiogenesis, protease activity, and bacterial toxicity. Therefore, visual pH monitoring without the need of removing the wound dressing was one of the aims of the Doctoral Dissertation. Produced stimuli-responsive wound dressings were characterized according to their morphological and chemical properties using well-known techniques such as, rheometry, conductivity, Scanning Electron Microscopy (SEM),CIE Lab, Thermogravimetric Analysis (TGA), UV/VIS Spectrophotometry, and Attenuated Total Reflection Infra-Red Spectroscopy (ATR-IR). Responsiveness of the nanofibers were achieved by integration of different halochromic dyes [bromocresol green (BCG), bromothymol blue (BTB) and thymol blue (TB)] to obtain a range of pH values. To tackle the problem of leaching of the dyes, a complexing agent; poly-diallyldimethylammonium chloride (PDADMAC) was integrated and an analysis on the formation of complexation was performed by using pH-potentiometric titration and Quartz Crystal Microbalance with Dissipation (QCM-D) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) techniques. Additionally, release tests were performed to prove that the leaching of the halochromic dyes is reduced significantly up to 97%. Furthermore, the responsiveness of the nanofibers was investigated by exposing the nanofibers to different buffer solutions with pH values 4, 7 and 10. The color change of the nanofibers were analyzed using the CIE Lab system while a visual color shift was observed according to their characteristics. Lastly, diclofenac (DFC), an anti-inflammatory drug molecule was integrated to the system and drug release studies were performed by using Franz diffusion cells. A controlled release of the drug molecule (DFC) to the wound bed is achieved and quantitative evaluations were done. Consequently, the drug release from the smart wound dressings were identified to have two separate profiles during the release. The mathematical models that were identified to fit to the kinetics are, first-order, Korsmeyer-Peppas, and Higuchi release model, confirming the controlled drug release.Type of material - dissertation ; adult, seriousPublication and manufacture - Maribor : [B. Elveren], 2023Language - englishCOBISS.SI-ID - 169277187
Author
Elveren, Beste
Other authors
Kurečič, Manja |
Volmajer Valh, Julija
Topics
stimuli-responsive |
polysaccharides |
wound dressings |
halochromism |
controlled drug release |
smart materials |
stimulativno odzivni |
polisaharidi |
obliži za rane |
halokromizem |
nadzorovano sproščanje zdravil |
pametni materiali |
doktorske disertacije
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Reserve material at the desired pickup location.
Pickup location |
Material status | Reservation |
---|---|---|
Newspaper Reading Room |
available - reading room
|
|
Main Reading Room |
available - reading room
|
Call number – location, accession no. ... |
Copy status |
---|---|
GS II 0000750424 glavno skladišče GS II 750424 glavno skladišče |
available - reading room
|
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Elveren, Beste | 53581 |
Kurečič, Manja | 24332 |
Volmajer Valh, Julija | 20238 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi