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Oxidative stress in lichen planusAly, Dalia Gamal ; Shanin, Rania SalahBackground. Increased reactive oxygen species (ROS) and lipid peroxides have been implicated in the pathogenesis of atopic dermatitis, psoriasis, vitiligo,and lichen planus (LP). We therefore ... evaluated the status of oxidative stress and the antioxidant defense system in Egyptian patients with LP. Methods. This study included 45 Egyptian LP patients and 45 healthy volunteers as controls that were age- and sex-matched with the patients. Serum levels of nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase(SOD), and erythrocyte catalase (CAT) were measured. Results. There was an increase in the serum levels of NO, SOD and the lipid peroxidation product MDA (p = 0, p = 0.009 and p = 0.005, respectively) and a decrease in CAT levels in LP patients compared to controls (p = 0), leading to an imbalance in the antioxidant defense system in our study. Oxidative stress was greater in men than in women because MDA levels were increased (p = 0.045)and erythrocyte CAT levels were decreased (p = 0). In addition, there was also a positive correlation between NO, MDA, and SOD and a negative correlation between erythrocyte CAT and the duration of LP. No relation between the four parameters and the clinical types of LP was noted. Conclusion. Our findings point to an increase in oxidative stress and an imbalance in the antioxidant defense mechanisms in LP. This may play a role inthe pathogenesis of LP.Source: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 19, no. 1, mar. 2010, str. 3-11)Type of material - article, component partPublish date - 2010Language - englishCOBISS.SI-ID - 26907097
Author
Aly, Dalia Gamal |
Shanin, Rania Salah
Topics
Lichen Planus |
Oxidative Stress |
Reactive Oxygen Species |
Nitric Oxide |
Blood |
Malondialdehyde |
Blood |
Superoxide Dismutase |
Blood |
Catalase |
Blood |
Lipid Peroxidation |
Lihen planus |
Dušikov oksid |
Malondialdehid |
Kisik, aktivne oblike |
Oksidativni stres |
Superoksidna dismutaza |
Lipidna peroksidacija |
Katalaza |
dermatologija |
kožne bolezni |
oksidativni stres
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source: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 19, no. 1, mar. 2010, str. 3-11)
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Aly, Dalia Gamal | ![]() |
Shanin, Rania Salah | ![]() |
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