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Imunoterapija : nova zdravila, drugačni sopojavi = Imunotherapy : new drugs, different adverse eventsOvčariček, TanjaImunoterapija je v zadnjih letih postala eden izmed pomembnih načinov sistemskega zdravljenja bolnikov z rakom. Priča smo bili različnim imunskim strategijam, med temi je tudi inhibicija kontrolnih ... točk. Zdravila proti CTLA-4, PD-1 in PD-L1 so protitelesa proti zaviralcem kontrolnih točk, ki lahko povišajo imunsko aktivnost proti rakavim celicam in tako ojačajo imunski odgovor proti raku. Večja uporaba teh zdravil pa je privedla do pojava posebne vrste imunsko pogojenih neželenih učinkov. Ti se najpogosteje izrazijo na koži, črevesju, žlezah z notranjim izločanjem, pljučih in mišično-skeletnem sistemu, lahko pa je prizadet kateri koli organ. Večina imunsko pogojenih neželenih učinkov je blagih do zmernih, v literaturi pa obstajajo poročila o hudih in življenje ogrožajočih. Pomembna je njihova zgodnja prepoznava in zdravljenje, kakor tudi multidisciplinaren pristop, da preprečimo resne zaplete.Source: Onkologija = Slovenian Journal of Oncology. - ISSN 1408-1741 (Letn. 22, št. 1, jun. 2018, str. 18-22)Type of material - article, component partPublish date - 2018Language - slovenianCOBISS.SI-ID - 2990715
Author
Ovčariček, Tanja
Topics
imunoterapija |
zaviralci kontrolnih točk |
neželeni učinki
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source: Onkologija = Slovenian Journal of Oncology. - ISSN 1408-1741 (Letn. 22, št. 1, jun. 2018, str. 18-22)
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Ovčariček, Tanja | 54060 |
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