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Activation of complement system by mannan pathway and Mbl2 genotypes in patients with type 2 diabetes and nephropathy = Aktivacija komplementnega sistema po mananski poti in genotipi gena Mbl2 pri bolnikih s sladkorno boleznijo tipa 2 in ledvično okvaroCerar Kišek, Tjaša, 1980- ...To add new evidence that complement activation by the mannan (lectin) pathway is involved in the pathogenesis of nephropathy in patients with type 2 diabetes, we collected blood and urine samples ... from 20 patients with type 2 diabetes and nephropathy and 20 apparently healthy individuals from the general population. We performed tests for complement activation analysis (CH50, APH50, C3, C4, C3d/dg, C4d, SC5b-9, MBL and genotyping of Mbl2 gene) in blood and (C3d/dg, C4d, MBL, and SC5b-9) in urine. We found significant signs of complement activation in patients with type 2 diabetes and nephropathy in blood and in urine. We also observed significant genetic differences between healthy individuals and patients with type 2 diabetes and nephropathy concerning the Mbl2 gene. Healthy individuals were apparently more heterogeneous (45 % A0 type) in presentation of the structural Mbl2 genotype, giving intermediate and low levels of MBL protein, compared to patients with type 2 diabetes and nephropathy, who had a very homogenous Mbl2 genome (75 % AA type) giving a high level of MBL production. From our data we can conclude that patients with type 2 diabetes and nephropathy presents more frequently with Mbl2 gene polymorphism giving high production of the MBL protein, what is very likely connected with acquired renal injury.Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 83, št. 10, okt. 2014, str. 661-669)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 31699417
Author
Cerar Kišek, Tjaša, 1980- |
Pongrac Barlovič, Draženka |
Zorin, Anže |
Gregorič, Nadan |
Kotnik, Vladimir
Topics
nephropathy |
diabetes |
complement |
mannan binding lectin |
nefropatija |
sladkorna bolezen |
komplement |
lektin
source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 83, št. 10, okt. 2014, str. 661-669)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Cerar Kišek, Tjaša, 1980- | 24350 |
Pongrac Barlovič, Draženka | 24466 |
Zorin, Anže | |
Gregorič, Nadan | 50051 |
Kotnik, Vladimir | 07756 |
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