Institute of Oncology, Lj. (OILJ)
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PARP inhibitor olaparib has a potential to increase the effectiveness of electrochemotherapy in BRCA1 mutated breast cancer in miceOmerzel, Maša, mag. farm. ...Electrochemotherapy (ECT), a local therapy, has different effectiveness among tumor types. In breast can-cer, its effectiveness is low; therefore, combined therapies are needed. The aim of our study ... was to com-bine ECT with PARP inhibitor olaparib, which could inhibit the repair of bleomycin or cisplatin inducedDNA damage and potentiate the effectiveness of ECT. The effects of combined therapy were studied inBRCA1mutated (HCC1937) and non-mutated (HCC1143) triple negative breast cancer cell lines.Therapeutic effectiveness was studied in 2D and 3D cell cultures andin vivoon subcutaneousHCC1937 tumor model in mice. The underlying mechanism of combined therapy was determined withthe evaluation ofcH2AX foci. Combined therapy of ECT with bleomycin and olaparib potentiated theeffectiveness of ECT inBRCA1mutated HCC1937, but not in non-mutated HCC1143 cells. The combinedtherapy had a synergistic effect, which was due to the increased number of DNA double strand breaks.Addition of olaparib to ECT with bleomycinin vivoin HCC1937 tumor model had only minimal effect,indicating repetitive olaparib treatment would be needed. This study demonstrates that DNA repar inhibiting drugs, like olaparib, have the potential to increase the effectiveness of ECT with bleomycin.Source: Bioelectrochemistry. - ISSN 1567-5394 (Vol. 140, 2021, str. 107832-1-10783-12)Type of material - article, component partPublish date - 2021Language - englishCOBISS.SI-ID - 66822915
Author
Omerzel, Maša, mag. farm. |
Jesenko, Tanja |
Markelc, Boštjan |
Janžič, Larisa |
Čemažar, Maja |
Serša, Gregor
Topics
elektrokemoterapija |
rak dojke |
olaparib |
bleomycin |
electrochemotherapy |
breast cancer |
olaparib |
bleomycin
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Author | Omerzel, Maša, mag. farm. ... |
Title | PARP inhibitor olaparib has a potential to increase the effectiveness of electrochemotherapy in BRCA1 mutated breast cancer in mice |
Publication date | 2021-05-01 |
COBISS.SI-ID | 66822915 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Kombinacija elektrokemoterapije in zaviralca poli (adenozin difosfat-riboza) polimeraze pri zdravljenju raka dojke | Z3-1871-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev | P3-0003-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Omerzel, Maša, mag. farm. | 34373 |
Jesenko, Tanja | 33227 |
Markelc, Boštjan | 32175 |
Janžič, Larisa | 53472 |
Čemažar, Maja | 14575 |
Serša, Gregor | 08800 |
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