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Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trialAndersen, Anders Nyboe ; Devroey, Paul ; Arce, Joan-CarlesBackground: LH activity may influence treatment response and outcome in IVF cycles. Methods: A randomized, assessor-blind, multinational trial compared ongoing pregnancy rates (primary end-point) in ... 731 women undergoing IVF after stimulation with highly purified menotrophin (HP-hMG) (n = 363) or recombinant FSH (rFSH) (n = 368) following a long GnRH agonist protocol. Patients received identical pre- and post-randomization interventions. One or two embryos were transferred on day 3. Results: More oocytes were retrieved (P< 0.001) after rFSH treatment (11.8) compared with HP-hMG treatment (10.0), but a higher proportion developed into top-quality embryos (P = 0.044) with HP-hMG (11.3%) than with rFSH (9.0%). At the end of stimulation, lower estradiol (E(2)) (P = 0.031) and higher progesterone (P < 0.001) levels were found with rFSH, even after adjusting for follicular response. The distribution of hypo-, iso- and hyper-echogenic endometrium showed a significant (P = 0.023) shift towards the hyperechogenic pattern after rFSH treatment. The ongoing pregnancy rate per cycle was 27% with HP-hMG and 22% with rFSH [odds ratio (95% confidence interval): 1.25 (0.89-1.75)]. Conclusion: Superiority of HP-hMG over rFSH in ongoing pregnancy rate could not be concluded from this study, but non-inferiority was established. Pharmacodynamic differences in follicular development, oocyte/embryo quality, endocrine response and endometrial echogenicity exist between HP-hMG and rFSH preparations, which may be relevant for treatment outcome.Source: Human reproduction. - ISSN 0268-1161 (Vol. 21, no. 12, 2006, str. 3217-3227)Type of material - article, component part ; adult, seriousPublish date - 2006Language - englishCOBISS.SI-ID - 3223871
Author
Andersen, Anders Nyboe |
Devroey, Paul |
Arce, Joan-Carles
Other authors
Vlaisavljević, Veljko |
Gavrić-Lovrec, Vida |
Reljič, Milan |
Kovač, Vilma, 1966- |
Kovačič, Borut |
Muršič, Jasna |
Kristovič, Marija |
Hanžel, Daniela |
Knuplež, Suzana |
Čižek-Sajko, Mojca |
Križančić Bombek, Lidija |
Herceg, Naca |
Piperski, Marija |
Hojnik, Nina, genetika |
Gorenjak, Maksimiljan
Topics
Infertility, Female |
therapy |
Neplodnost, ženska |
Zdravljenje |
Fertilization in Vitro |
Oploditev in vitro |
Follicle Stimulating Hormone |
therapeutic use |
Folikel stimulirajoči hormon |
Terapevtska raba |
Embryo Transfer |
Zarodek, prenos |
Menotropins |
therapeutic use |
Menotropini |
Terapevtska raba |
Recombinant Proteins |
therapeutic use |
Rekombinantni proteini |
Terapevtska raba |
Oocyte Donation |
Oocit, dajalka |
Pregnancy Outcome |
Nosečnost, izid
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Andersen, Anders Nyboe | ![]() |
Devroey, Paul | ![]() |
Arce, Joan-Carles | ![]() |
Vlaisavljević, Veljko | 08996 |
Gavrić-Lovrec, Vida | 08397 |
Reljič, Milan | 15711 |
Kovač, Vilma, 1966- | 20136 |
Kovačič, Borut | 11040 |
Muršič, Jasna | ![]() |
Kristovič, Marija | ![]() |
Hanžel, Daniela | ![]() |
Knuplež, Suzana | ![]() |
Čižek-Sajko, Mojca | 20134 |
Križančić Bombek, Lidija | 24423 |
Herceg, Naca | ![]() |
Piperski, Marija | ![]() |
Hojnik, Nina, genetika | ![]() |
Gorenjak, Maksimiljan | 07616 |
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