Search results

卒中是导致死亡和致残的首要病因,卒中救治具有高度的时间依赖性,快速开通闭塞血管是急性缺血性卒中救治的关键.5G智慧移动卒中急救系统(5G smart mobile stroke emergency ... system,5G+SMSES)通过物理终端层实现关键且快速的数据采集,网络传输层实现实时且可靠的数据传输,系统应用层实现智能且全面的数据应用,并通过大屏进行数据集中化展示.同时5G+SMSES具有移动应急救援子系统、卒中救治质控子系统、卒中急救共享云子系统、卒中专病数据库子系统及卒中救治指挥中心子系统五个功能分区.通过5G+SMSES打破了院前急救、院内诊治的传统"串联"模式,真正实现了"上车即入院""卒中急救无等待"的高效卒中救治新模式. more

快速城市化驱动的不透水面比例增加是引起流域洪峰和径流总量增加的直接原因,海绵城市建设通过生态基础设施网络构建增加流域透水面比例,是重构流域生态水文过程的重要途径.但是海绵城市建设在流域海绵体生态水文过程中发挥的作用尚不清楚.以深圳市布吉河流域洪湖片区为例,通过雨季水文过程要素在线连续监测来确定海绵城市建设是否改善洪湖片区生态水文过程.结果表明,中观尺度上,雨季降雨量对洪湖片区地表径流总量无直接影响,降雨强度显著影响洪湖片区地表径流峰值流量(P<0.05),日降雨量对布吉河水质影响极显著(P<0.01).洪湖片区通过28.3％(0.85 km2)海绵面积建设,透水面比例提升,以生物滞留设施和透水铺装等强化片区蒸散和下渗过程,减少雨季径流97.2％(248.72万m3),削减典型降雨峰值流量98.2％以上,降低易涝点积水水位至7.8 cm以下,2.8％形成河川径流(布吉河),海绵面积(比例)和地表径流量削减无直接量化关系.洪湖片区污染物截留时空随保水能力得到提升,控制排放悬浮物月均浓度均低于15.60 mg/L,污染物通过径流裹挟进入布吉河的总量和速率降低,促使布吉河黑臭消除、水质提升至IV类.海绵城市建设对微观尺度生态水文过程的影响与中观尺度存在差异,降雨量等因素与典型项目生态水文过程量化关系不明显.学校、道路和社区公园利用绿色屋顶、透水铺装等强化下渗、蒸散,可削减雨季径流99.0％以上、削减峰值流量97.0％以上,控制悬浮物月均浓度低于17.10 mg/L.总之,以上研究结果强烈表明海绵城市中微观尺度源头减排设施和调蓄设施的耦合建设模式可以削减洪湖片区径流总量、峰值流量、积水水位和径流污染,是一种改善相似流域生态水文过程的有效途径.

O657.63; ... 依据阿卡波糖及其类似物的质谱特征碎片,建立了高效液相色谱-串联质谱(HPLC-MS/MS)法从20种不同来源的发酵液中快速筛选阿卡波糖及其类似物产生菌.发酵液经阳离子型固相萃取柱纯化后,采用HPLC-MS/MS筛选分析.通过归纳阿卡波糖及其类似物的特征离子碎片,总结裂解途径,得出具有C7N单元化合物的共有特征碎片,并以质谱能量分辨曲线对实验结果加以判断.该分析方法结合超高效液相色谱分离与质谱多反应监测扫描模式,可实现阿卡波糖及其类似物产生菌的筛选,对其选育提供了重要的实验思路. more

R285.5; 目的 探讨八子补肾胶囊(BZBS)对D-半乳糖(D-gal)和亚硝酸钠(NaNO2)诱导的衰老小鼠的骨保护作用及可能的作用机制.方法 ICR雄性小鼠连续腹腔注射D-gal和NaNO2三个月造成衰老小鼠模型,并于造模第25天开始用BZBS干预,连续干预65 ... d.然后收集股骨,分别用HE染色评价骨微结构的变化,三点弯曲实验评估骨生物力学性能,Micro-CT扫描观察骨组织形态计量学参数,红外光谱法分析骨材料特性,免疫组织化学染色法测定骨组织中的SIRT6、NF-κB和cathepsin K蛋白表达水平.结果 BZBS能明显抑制D-gal和NaNO2诱导的衰老小鼠的骨形态破坏,提高骨组织矿物质含量.此外,BZBS能上调衰老小鼠血清中的T-AOC、SOD、GSH、GSH/GSSG水平,降低MDA水平,提高骨组织中SIRT6的表达,抑制NF-κB乙酰化,降低cathepsin K的表达.结论 BZBS能提高衰老小鼠的骨质量,这种作用可能与调节氧化还原平衡进而调控SIRT6/NF-κB/cathepsin K信号通路有关. more

O657.63; ... 利用高分辨质谱数据进行非目标筛查时,为提高分子式预测的前位命中率,为化合物的进一步筛查提供可靠的参考信息,本研究开发了基于分子式数据库策略的分子式计算器FM-searcher.该软件基于“存在即合理,大量存在即稳定”的核心思想,根据分子式在已有化合物数据库中出现的频率对分子式进行计算和排序,并依据排序对获得分子式的合理性进行判断,以提高分子式计算的合理性和前位命中率.以测定及搜集文献所得兽残、生物毒素等多类危害物共计219个精确分子质量作为测试数据,将该计算器计算的分子式前位命中率与普通算法(Xcalibur内嵌计算器)的计算结果进行比较.结果 表明,FM-searcher在无任何元素限制时,仍可获得较高的前位命中率,前5、前3及首位命中率分别为91.8％、82.6％和50.7％;而普通算法在模糊限制元素时,其命中率分别为21.0％、15.1％、6.4％.在分小类精确限制元素组成时,得到的结果分别为82.2％、69.9％、48.9％.对实际样品基质中测定得到精确质量数的分子式进行计算,FMsearcher能够获得比普通计算器更高的正确分子式前位命中排位.该方法与普通算法相比,能够在更宽泛的限制条件下大幅提高分子式预测的前位命中率,简化分子式计算过程,减少数据处理量,且操作简便、实用性较强. more

研究了壳聚糖双胍盐酸盐（CGH）对柑橘绿霉菌和柑橘青霉菌的抑菌能力，并通过涂膜的方法处理砂糖橘，测定了贮藏过程中果实失重率、可溶性固形物含量（TSS）、维生素C（Vc）含量及总酸含量（TA）的变化。结果表明，与壳聚糖（CTS）比较，CGH对柑橘绿霉菌和柑橘青霉菌具有较强的抑菌能力，当CGH浓度为0．4mg／mL和5．0mg／mL时，可分别完全抑制柑橘青霉菌和柑橘绿霉菌的生长；质量浓度为2％的CGH涂膜处理的砂糖橘在28（±2）℃下存放27d后，失重率仅为2．25％，TSS为13．7％，Vc含量为每100g砂糖橘鲜重含有15．01mg、可滴定酸含量为0．85％。与对照相比，CGH涂膜较好地保持了果实的品质。

根据目前在 SDH传输网管中存在的快速开通光路和电路的具体需求 ,针对由若干环构成的网络拓扑较为复杂的 SDH传输网提出了光电路路由算法和电路路由算法 ,算法以光电路分层模型为基础进行 ,能迅速进行光路和电路的路由调度 .最后对算法进行了简单的分析

To analyze the rules of acupoint selection in adjuvant interventions for in vitro fertilization-embryo transfer (IVF-ET) with acupuncture and moxibustion, with the use of complex network technology. ... Articles on clinical trials of acupuncture and moxibustion for IVF-ET were searched in the China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, and Web of Science databases from inception to January 31, 2020. A database of acupoint prescriptions has been established. Descriptive analysis was conducted using Microsoft Excel 2019, association rule analysis was conducted using SPSS Modeler 18.0 Apriori algorithm, clustering analysis of high-frequency acupoints was performed using SPSS 25.0 Ward, and complex network analysis of acupoints was performed by using Gephi 0.9.2. A total of 124 clinical trials were included, and 187 acupoint prescriptions were extracted, for a total of 91 acupoints. The total frequency of using these acupoints was 1,296 times, with Sānyīnjiāo (三阴交SP6) used the most frequently. The acupoints were generally located around the conception vessel, spleen meridian, and stomach meridian, and they were mainly distributed in the lower extremities, chest, and abdomen. Considerable consideration was paid to the specific points. The association rule analysis showed that the highest correlation presented between Guānyuán (关元CV4) and Zĭgōng (子宫EX-CA1). Complex network k-core hierarchical analysis discovered that CV4, SP6, Xuèhăi (血海SP10), Hégŭ (合谷LI4), Tàichōng (太冲LR3), Qìhăi (气海CV6), and EX-CA1 were the core acupoints in adjuvant interventions with acupuncture-moxibustion for IVF-ET. In adjuvant interventions with acupuncture-moxibustion, acupoints were commonly located around the conception vessel, spleen meridian, and stomach meridian, and the convergent point was particularly used as a specific point. The acupoints were selected to smooth the liver qi, remove stagnation, activate blood circulation, resolve stasis, and benefit the liver and kidney. “CV4→SP6→EX-CA1→ST36” were the core points, and CV4 was the core prescription in adjuvant treatments with acupuncture-moxibustion in IVF-ET. more

The disc cutters of tunnel boring machine (TBM) are installed with different polar angles. This causes the cutting depth difference between adjacent disc cutters on the tunnel face. A rock-cutting ... model was established to study the rock fragmentation law between adjacent disc cutters with different polar angles based on particle flow code (PFC). The influence of polar angle of adjacent disc cutters on rock cracks and stresses under different cutter spacing and penetration was studied. Research shows that polar angle difference leads to the discontinuity of rock-fragmentation process by adjacent cutters. The effect of rock-fragmentation is influenced by the cutting depth difference between adjacent cutters. The effect of rock-fragmentation performed best, meanwhile large rock blocks were flaked when the difference of cutting depth is half of the penetration. Too large or small difference of the cutting depth will cause high specific energy consumption of rock fragmentation. The specific energy consumption is relatively small when the difference of cutting depth is half of the penetration. more