Abstract
Background
The Lequesne Algofunctional Index of Knee Osteoarthritis (LAIKOA) is a widely used knee osteoarthritis (KOA) outcome measure and is recommended by many international authorities. ...It has been cross-culturally adapted to many languages, excluding indigenous Nigerian languages. The aim of this study was to cross-culturally adapt and validate the LAIKOA into Yoruba language.
Methods
This was a validation study. Yoruba LAIKOA was translated and culturally adapted from English version following Beaton’s guidelines (including cognitive debriefing). The Yoruba LAIKOA was psychometrically tested for test-retest reliability, standard error of measurements (SEM), smallest detectable change (SDC), internal consistency, and construct validity among 108 Yoruba-speaking patients with KOA recruited from selected hospitals in Ibadan, Nigeria. Participants completed the Yoruba and English versions of LAIKOA, and the Yoruba version of Ibadan Knee/Hip Osteoarthritis Outcome Measure (IKHOAM).
Results
The mean age of participants was 63.60 ± 11.77 years. Acceptable internal consistency was observed for the global index and function domain (α = 0.63–0.82) and good test-retest for items and domains (ICC = 0.81–0.995). Item-to-scale correlation was significant (r = 0.28–0.69). Its three domains demonstrated structural validity when subjected to confirmatory factor analysis (CFI = 0.99, TLI = 0.99, RMSEA = 0.02). Construct validity was supported by the correlation between Yoruba LAIKOA and IKHOAM (r = -0.39, p = 0.011). The overall scores and domain scores of the Yoruba and English versions of LAIKOA did not differ significantly. The Yoruba LAIKOA has no floor or ceiling effects.
Conclusion
The Yoruba LAIKOA is reliable and valid, and it is recommended for use in clinical settings in southwestern Nigeria and other Yoruba-speaking populations.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Understanding patterns of physical activity and sedentary time is important to effective population-wide primary prevention and control of non-communicable diseases. This study examined the patterns ...of objectively assessed physical activity and sedentary time, and the prevalence of compliance with physical activity guidelines according to different public health recommendations in a sub-population of health professional students in Nigeria.
A cross-sectional study was conducted among 102 health professional students (age = 19-34 years old, 43.1% women) of the University of Maiduguri, Nigeria. Participants wore Actigraph accelerometers on their waist for minimum of 5 days/week to objectively measure intensity and duration of physical activity and sedentary time. Prevalence and demographic patterns of physical activity and sedentary time were examined using descriptive and inferential statistics.
The students spent most time in sedentary activity (458.6 ± minutes/day, about 61% of daily time) and the least in vigorous-intensity activity (2.1 ± 4.4 minutes/day, about 0.3% of daily time). Sedentary time was higher among older than younger students (P<0.038) and among medical laboratory science students than physiotherapy and nursing students (P = 0.046). Total physical activity was higher among nursing and medical students than medical laboratory science students (P = 0.041). Although, 85.3% of the students engaged in 150 minutes/week of moderate-to-vigorous physical activity, only 2.9% met the guideline of 75 minutes/week of vigorous intensity activity.
Prevalence of sedentary time was high while that of vigorous-intensity activity was very low among health professional students in Nigeria. Compliance with physical activity guidelines was mainly through accumulation of moderate intensity activity. The results suggest that age and academic programme may influence physical activity level and sedentary behaviour of health professional students in Nigeria. These findings provide preliminary evidence that could be used to inform the needs to develop interventions to improve and support active lifestyle behaviour among students in Nigerian universities.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Several anthropogenic activities produce radioactive materials into the environment. According to reports, exposure to high concentrations of radioactive elements such as potassium (
40
K), uranium (
...238
U and
235
U), and thorium (
232
Th) poses serious health concerns. The scarcity of reviews addressing the occurrence/sources, distribution, and remedial solutions of radioactive contamination in the ecosystems has fueled data collection for this bibliometric survey. In rivers and potable water, reports show that several parts of Europe and Asia have recorded radionuclide concentrations much higher than the permissible level of 1 Bq/L. According to various investigations, activity concentrations of gamma-emitting radioactive elements discovered in soils are higher than the global average crustal values, especially around mining activities. Adsorption technique is the most prevalent remedial method for decontaminating radiochemically polluted sites. However, there is a need to investigate integrated approaches/combination techniques. Although complete radionuclide decontamination utilizing the various technologies is feasible, future research should focus on cost-effectiveness, waste minimization, sustainability, and rapid radionuclide decontamination. Radioactive materials can be harnessed as fuel for nuclear power generation to meet worldwide energy demand. However, proper infrastructure must be put in place to prevent catastrophic disasters.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Physiotherapists are known to be prone to Work- related musculoskeletal disorders (WRMDs) but its prevalence among physiotherapists in Nigeria has not been reported. This study investigated the ...prevalence and work factors of WRMDs among physiotherapists in Nigeria.
A cross- sectional survey was administered to physiotherapists in different parts of Nigeria using a 2- part questionnaire with items adopted from questionnaires used for similar studies around the world. Two hundred and seventeen copies of the questionnaire were distributed for self administration but 126 physiotherapists returned completed surveys for a 58.1% response. The data were analyzed using SPPS version 10 at alpha level of 0.05. Descriptive statistics of frequency and percentages and inferential statistics of chi2 were used as appropriate for data analysis.
Reported 12- month prevalence of WRMDs among Nigerian physiotherapists was 91.3%. Prevalence of WRMDs was significantly higher in female physiotherapists (p = 0.007) and those with lower body mass index (p = 0.045). The low back (69.8%) was the most commonly affected body part, followed by the neck (34.1%). Fifty percent of the physiotherapists first experienced their WRMDs within five years of graduation and the highest prevalence (61.7%) was found among physiotherapists younger than 30 years. Treating large number of patients in a day was cited by most (83.5%) of the respondents as the most important work factor for their WRMDs. The most commonly adopted coping strategy identified was for the therapists to modify their position and/or the patient's position (64.3%). Majority of the respondents (87.0%) did not leave the profession but 62.6% changed and/or modified their treatment because of their WRMDs.
The prevalence of WRMDs among physiotherapists in Nigeria is higher than most values reported for their counterparts around the world. The coping strategies and work factors of WRMDs among Nigerian physiotherapists are mostly similar to those of their counterparts elsewhere.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is, however, limited information available on the specific ...neuronal cell type in the MePD functionally mediating these behaviours in rodents. The recent discovery of a significant kisspeptin neurone population in the MePD has raised interest in the possible role of kisspeptin and its cognate receptor in sexual behaviour. The present study therefore tested the hypothesis that the MePD kisspeptin neurone population is involved in regulating attraction towards opposite sex conspecifics, sexual behaviour, social interaction and the anxiety response by selectively stimulating these neurones using the novel pharmacosynthetic DREADDs (designer receptors exclusively activated by designer drugs) technique. Adult male Kiss‐Cre mice received bilateral stereotaxic injections of a stimulatory DREADD viral construct (AAV‐hSyn‐DIO‐hM3D(Gq)‐mCherry) targeted to the MePD, with subsequent activation by i.p. injection of clozapine‐N‐oxide (CNO). Socio‐sexual behaviours were assessed in a counter‐balanced fashion after i.p. injection of either saline or CNO (5 mg kg‐1). Selective activation of MePD kisspeptin neurones by CNO significantly increased the time spent by male mice in investigating an oestrous female, as well as the duration of social interaction. Additionally, after CNO injection, the mice appeared less anxious, as indicated by a longer exploratory time in the open arms of the elevated plus maze. However, levels of copulatory behaviour were comparable between CNO and saline‐treated controls. These data indicate that DREADD‐induced activation of MePD kisspeptin neurones enhances both sexual partner preference in males and social interaction and also decreases anxiety, suggesting a key role played by MePD kisspeptin in sexual motivation and social behaviour.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Abundant coal resources that were previously neglected due to a crude oil boom need revitalisation and integration into the national electricity mix to address the energy demands of the Nigerian ...population. Selected coal samples from the Benue Trough sedimentary basin in Nigeria were examined by various techniques, including proximate and ultimate analyses, organic petrography, Fourier transform infrared ray spectroscopy, and thermogravimetric analysis. Based on vitrinite reflectance, the Lafia-Obi (OLB), Garin Maiganga (GMG), Imiegba (IMG), and Okaba (OKB) coals are classified as subbituminous, while the Lamja1 (LMJ1), Lamja2 (LMJ2) and Chikila (CHK) coals are high volatile B bituminous. The Enugu (ENG) coal is on the boundary between subbituminous and high volatile C bituminous. Organic petrographic results indicate vitrinite and fusinite contents steadily increase from the Lower Benue Trough coals to the Upper Benue Trough coals, while semifusinite and total mineral contents follow a reverse pattern. Thermal decomposition occurred in three stages, i.e., drying, devolatilization, and coke formation above 700 °C; and the coal reactivity follows the following order, ENG > IMG > IGH > CHK > LMJ > OKB > GMG > LFB. The higher temperatures (above 900 °C) are required to decompose the coals for efficient energy recovery. The LMJ1, LMJ2, OLB, CHK, GMG, and OKB coals can be exploited for electricity power generation. However, the Imeagha and Enugu coals are best suitable for both cement and power generation.
Background
This study reports a new, cost-effective and validated method for the determination of ceftriaxone (CFR). The method involved charge transfer (CT) complexation reaction of ceftriaxone (as ...n-electron donor) and N-(2,4-dinitro-1-naphthyl)-p-toluenesulphonamide {N-(2,4-DN1NL) PTS} as π-electron acceptor to form a complex. Ultraviolet, infrared and
1
H NMR spectra of CFR, N-(2,4-DN1NL) PTS and adduct were then studied to predict the site of interaction between the donor and acceptor.
Result
The complex formed had deep golden-yellow colour, having a new absorption band at 440 nm. Molar absorptivity of 1.667 × 10
5
L M
−1
cm
−1
was obtained. The complexation reaction was completed at 30 °C optimal temperature within 10 min. Acetonitrile was found to be the best diluting solvent for optimal detector response and the complex was stable (absorbance unchanged) at room temperature for hours. At concentration of 1.708–11.956 µg mL
−1
, with low limits of detection of 0.143 µg mL
−1
, Beer’s law was observed. Between-day recovery statistics of CFR from quality control samples were 102.15 ± 0.062 (% RSD = 0.61, n = 12) over three days. The site of interaction of donor and acceptor molecules, as revealed through infrared (IR) and proton nuclear magnetic resonance studies (
1
H NMR) and the formation of charge transfer complex is through intermolecular hydrogen bonding between the amino group of the donor and the acidic proton of the acceptor. Common tablet excipients, as observed, did not interfere with the analytical method and no significant difference existed between the results of this new method and the high performance liquid chromatographic procedures (p > 0.05) documented in the USP. The new CT procedure described in this paper is not only simple but also fast, accurate and precise. Also, the reactions were carried out at room temperature compared to previously described procedures.
Conclusions
This novel method could therefore be adopted as a fast but cost-effective alternative for the qualitative and quantitative assessment of CFR in its pure and dosage form. It could find usefulness in on-the-spot detection of counterfeit drugs and in field inspections with reliable accurate results that compares with established methods.
Background: Anxiety and depression are common mental disorders that are not only on the increase, but their comorbidity accounts for greater severity, chronicity, functional limitations and ...significant impairment of physical health. Objective: The objective of this study is to determine the prevalence of comorbid anxiety and depression (CAD) among patients attending the General Outpatient Clinic, which could help increase the index of suspicion of these disorders and subsequently improve overall patient care. Methods: A hospital-based cross-sectional study was carried out at the General Outpatient Clinic of Bowen University Teaching Hospital, Ogbomoso, between August and November 2021. Using a systematic sampling technique, 222 respondents were recruited. CAD was evaluated using the Generalized Anxiety Disorder Scale and Patient Health Questionnaire. SPSS version 26 was used for data analysis. Frequency and percentages were calculated, and Chi-square was used to test for significant association with a p-value set at <0.05. Results: CAD was found among 27.5% of the study participants. Age group above 75 years, male gender, married participants, skilled workers, participants having monthly income between ₦51,000 - ₦100,000 (equivalent to USD100-200) and those with diabetes had the highest prevalence of CAD. Male gender had a statistically significant association with CAD. Conclusion: It is, therefore, imperative to increase awareness of CAD with a focus on the male gender to commence treatment promptly when identified.
The paper focuses on collection of information on recent multifaceted usage of biomass materials with critical examination on its sustainability. The use of biomass is becoming popular, with wide ...global acceptance as it is considered as green technology. The use of biomass products across industrial parallels, the material combination and production processes were elucidated in this paper. Biomass materials are seen as affordable alternative to conventional materials for domestic and industrial applications. The multifaceted use of biomass, which includes, energy generation, metallurgical applications, construction purposes, reinforcement in metal matrix composite, microelectromechanical system, biochemical and traditional medicine were discussed. This underscores the need to develop a sustainable plan to meet with its diverse usage to be beyond laboratory efforts. This paper examined whether the availability of biomass can sustain its multifaceted usage or not. It also examined the modalities to ensure sustainable use of biomass. Different policies were highlighted and discussed in line with continuous multifaceted use of biomass.
Biomass; Multifaceted; Construction; Energy; Traditional medicine; Direct reduced iron; Metal matrix composite
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPUK, ZAGLJ, ZRSKP
Aims/hypothesis Increased circulating methylarginines (MA) have been linked to the metabolic syndrome to explain endothelial dysfunction and cardiovascular disease risk. Proteins that contain MA are ...regulatory and release them during catabolism. We hypothesised that increased protein turnover in insulin-resistant states contributes to an increase in circulating MA. Matwerials and methods We performed hyperinsulinaemic, euglycaemic, and isoaminoacidaemic experiments on 49 lean, obese and elderly subjects, with measurements of the kinetics of glucose and protein metabolism. Plasma MA, i.e. asymmetrical dimethylarginine (ADMA), symmetrical dimethylarginine (SDMA), and N -monomethyl-l-arginine (NMMA), lipids and body composition were measured. Results Insulin resistance of glucose and protein metabolism occurred in obese and elderly subjects. ADMA concentrations were 29 to 120% higher in obese and 34% higher in elderly than in lean subjects. SDMA were 34 and 20% higher in obese than in lean and than in elderly subjects, respectively. NMMA were 32% higher in obese than in lean subjects. ADMA differed by sex, being higher in men, namely by 1.75x in obese men and by 1.27x in elderly men. Postabsorptive ADMA (r=0.71), SDMA (r=0.46), and NMMA (r=0.31) correlated (all p<0.05) with rates of protein flux. All three MA correlated negatively with clamp glucose infusion rates and uptake (p<0.001). ADMA and SDMA correlated negatively with net protein synthesis and clamp amino acid infusion rates (p<0.05). All MA also correlated with adiposity indices and fasting insulin and triglycerides (p<0.05). Conclusions/interpretation Obesity, sex and ageing affect MA. Elevations of the three MA in obese, and of ADMA in elderly men, are related to increased protein turnover and to lesser insulin sensitivity of protein metabolism. These interrelationships might amplify insulin resistance and endothelial dysfunction.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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