Abstract
In fact, the teaching materials are still using teaching books, so in the learning media courses will be developed based on digital art teaching materials at Universitas Muhammadiyah ...Tapanuli Selatan. In the development of the teaching materials contain teaching materials tailored to the curriculum that applies with the tools and materials contained in the environment. Research objectives to know the expert opinion on the feasibility test and influence of the development of digital art-based teaching materials. Research and Development (R&D) method of ADDIE model (Analyze, Design, Development, Implementation, and Evaluation). For the average result of expert validator assessments on this study covers aspects of feasibility standards based on BSNP by 3.27, then the validity criteria is quite good (quite valid and need revision). The result of student learning creativity Assessment was obtained at 3.18, hence the creativity category is creative.
Tujuan penelitian ini adalah untuk mendeskripsikan dinamika dan kontribusi pendidikan muhammadiyah di Indonesia khusunya di Sekolah Dasar (SD). Metode penelitian merupakan sebuah penelitian studi ...kasus. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Partisipan penelitian ini adalah guru di SD Muhammadiyah. Teknik analisis data menggunakan triangulasi. Hasil penelitian ini menunjukkan bahwa pengembangan pendidikan muhammadiyah di sekolah dasar diinternalisasikan pada setiap proses pembelajaran dilakukan melalui perencanaan, pelaksanaan, dan evaluasi. SD Muhammadiyah memberikan pelayanan pendidikan serta mengembangkan keterampilan, minat dan bakat anak melalui program ekstrakurikuler. Program ekstrakurikuler diantaranya adalah Pramuka dan Pencak silat. SD Muhammadiyah juga sangat mengedepankan nilai-nilai keislaman dan kemuhammadiyahan melalui kegiatan-kegiatan Baca Tulis Al- Qur”an, Hafalan Hadist, Bahasa Arab, Doa Harian, Shalat Dhuha, Shalat Berjamaah, Peringatan Hari Besar Muhammadiyah dan Islam.
Video is an electronic media that is able to combine audio and visual technology together so as to produce a dynamic and interesting impression. The purpose of the study was to find out the ...assessment of expert validators in viva video learning media feasibility test based on BSNP questionnaire. The benefits of this research provide interesting and enjoyable learning activities so that students become more active in learning, as well as enrich the teacher’s knowledge about alternative learning media. The average result of all aspects of the standardized due diligence based on the BSNP questionnaire before revision 3.12 with validity criteria is quite good {Quite valid and needs revision}. Meanwhile, after revision 3.76 with validity criteria both {Valid and do not need revision (feasible)}. The development of viva video media in electrolyte and non electrolyte solution material is expected to be applied to students in school.
Keywords: Viva Video; digital art; learning media; BSNP
Tujuan penelitian ini adalah untuk mengetahui keefektifitasan model pembelajaran Glaser pada bidang studi pendidikan kewarganegaraan dan untuk mengetahui minat belajar peserta didik pada bidang studi ...pendidikan kewarganegaraan.Berdasarkan analisa data di atas, maka diperoleh nilai hitung = 0,993 Selanjutnya penulis menetapkan nilai rxy tabel pada taraf kesalahan 5 % dengan N = 34 orang peserta didik adalah 0,339, dan taraf kesalahan 1 % adalah 0,436 (lihat daftar tabel terlampir). Untuk menguji kebenaran hipotesis dilakukan dengan ketentuan untuk melihat pengaruh nilai rxy hitung dengan rxy tabel, dimana apabila nilai rxy hitung lebih besar dari rxy tabel maka hipotesis alternatif (Ha) diterima kebenarannya ekefektivitas model pembelajaran glaser terhadap minat belajar peserta didik pada bidang studi pendidikan kewarganegaraan (PKn) dan H0 ditolak, dan sebaliknya apabila nilai rxy hitung lebih kecil dari rxy tabel, maka Ho diterima dan Ha ditolak kebenarannya yaitu tidak ada peran guru secara psikologis terhadap minat belajar peserta didik dengan materi pokok hakikat demokrasi dan macam-macam demokrasi pada bidang studi Pendidikan Kewarganegaraan.Kata Kunci: Pembelajaran, Glaser, Dalam, Meningkatkan, Minat, Belajar
Ebola still remains as one of the most problematic infectious diseases in Africa with a high rate of mortality. Although this disease has been known for an almost half-century, there are no vaccines ...and drugs available in the market to treat Ebola. Zaire ebolavirus (EBOV), a single-stranded RNA virus which belongs to Filoviridae family and Mononegavirales order, is one of the virus causing Ebola. As one of seven proteins that EBOV encodes, Ebola virus nucleoprotein (EBOV NP) plays an imperative role in EBOV proliferation cycle. Therefore, the development of a new Ebola treatment can be targeted towards EBOV NP.
In this work, we screened about 190,084 natural product compounds from ZINC15 database through in silico virtual screening and flexible docking simulation. Furthermore, the bioavailability and toxicity prediction have been conducted as well. Two best ligands according to the simulation and prediction tests were progressed into the molecular dynamics simulation.
In the end, we found that our proposed ligands, namely α-lipomycin (ZINC56874155) and 3-(((S)-1-amino-1,2,3,4-tetrahydroisoquinolin-5-yl)methyl)-5-((5-((5R,7S)-5,7-dihydroxy-3-oxodecyl)-2-hydroxyphenoxy) methyl)pyrrolo3,4-bpyrrol-5-ium (ZINC85628951), showed the promising results to be developed as a lead compounds for treating Ebola. Therefore, an experimental study is required to validate their inhibition activities against EBOV NP.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Epimutation by DNA Methyltransferase 1 (DNMT1), an epigenetic regulator enzyme, may lead to the proliferation of breast cancer. In this report, 168,686 natural products from the PubChem database were ...screened and modified by in silico method to acquire the potential inhibitor of DNMT1. The initial screening of PubChem natural products using Lipinski's and Veber's rules of three and toxic properties have resulted in 2601 fragment candidates. Four fragments from pharmacophore-based molecular docking simulation were modified by utilizing FragFP and the Lipinski's and Veber's rules of five, and resulted in 51,200 ligands. The toxicological screening collected 13,563 ligands for a series of pharmacophore-based molecular docking simulations to sort out the modified ligands, which had the better binding activity and interactions to DNMT1 compared to the standards, SAH, SAM, and SFG. This step resulted in five ligand candidates, namely C-7756, C-5769, C-1723, C-2129, and C-2140. The ADME-Tox properties prediction showed that the selected ligands are generally better than standards in terms of druglikeness, GI absorption, and oral bioavailability. C-7756 exhibited a stronger affinity to DNMT1 as well as better ADME-Tox properties compared to the other ligands.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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•About 614 ligands were computationally modified from 313 commercial cyclic peptides and an HIV-1 Tat peptide.•The ligands were tested against EBOV NHR GP2 ectodomain through ...molecular docking simulation, resulting 26 ligands which have lower free binding energy compared to the standards.•Computational pharmacological properties prediction was employed to determine the ADMET properties of the selected ligands.•Ligand 023 RMSD calculation from molecular dynamics simulation shows a promising stability to maintain its molecular interaction with the EBOV NHR GP2 ectodomain.
Ebola Hemorrhagic Fever (EHF) is a disease caused by viruses from genus Ebolavirus. Zaire ebolavirus (EBOV) is the deadliest species which has 76% case fatality rate. Up until now, there is no U.S. Food and Drug Administration (FDA) approved drugs to treat EHF. Antiviral drug based on EBOV N-terminal heptad repeat glycoprotein-2 (NHR GP2) Ectodomain inhibitor is one kind of treatment that has not well developed. NHR GP2 Ectodomain has an important role in the process of EBOV entry into the cell through endocytosis mechanism. In this study, we used in silico methods to investigate the activity of commercial cyclic peptide conjugated to Human Immunodeficiency Virus type 1 Trans-activator of the transcription (HIV-1 Tat) peptide as ligands which act as an inhibitor of EBOV NHR GP2 Ectodomain. The commercial cyclic peptides which we used in this study were obtained from the selected chemical companies. Conjugation of the commercial cyclic peptides to HIV-1 Tat peptide was done in order to accumulate it inside the endosome. The ligands which had the best inhibition properties were screened using molecular docking and molecular dynamics simulation. Prediction of pharmacological properties of the peptides was done to choose the best drug candidate. The result of screening processes shows that Ligand 023 has the highest potency as the drug lead. The ligand needs to undergo further analysis through in vitro, in vivo, and a clinical trial to ensure that this ligand has a therapeutic ability as an antiviral drug for Ebola virus infection.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Dengue virus (DENV) has emerged as one of the most prevalent viruses in sub-tropical countries, yet there is no commercial drug available to combat DENV infection effectively. The RNA-capping and ...replication processes of DENV are regulated by NS5 methyltransferase (MTase). Hence, NS5 MTase is believed as a promising drug target for DENV. In this research, the DENV NS5 MTase was subjected to 6,842 Northern African Natural Product Database (NANPDB) compounds through computational simulation methods. Three crystal structures of DENV NS5 MTase, which contained S-adenosylhomocysteine (PDB ID: 4V0Q), S-adenosylmethionine (PDB ID: 3P97), and sinefungin (PDB ID: 4R8S), were used as the core template of the pharmacophore mapping in the SAH-binding site of DENV NS5 MTase. Four amino acid residues (Glu111, Asp131, Val132, and Asp146) were found to strongly interacted with SAH, SAM, and SFG, indicating that these residues may hold a vital role on the catalytic activity of DENV NS5 MTase. From the docking simulations, three ligands showed favorable inhibition activities by having lower ΔG binding value than the standard ligands. Rutin has the lowest ΔG binding value at -12.3586 kcal/mol, followed by isorhamnetin 3-rutinoside (-12.3203 kcal/mol), and tetra-o-galloyl glucose (-12.2039 kcal/mol). Pharmacological properties of these ligands were analyzed; no potential harmful effect was detected. Therefore, these ligands can be suggested as drug candidates for treating DENV infection by targeting SAH-binding site of NS5 MTase. The ligands efficacy needs to be validated through a series of in vitro, in vivo and clinical studies.
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