For many years now, biologists are studying the numbers of harmful species, and regulatory factors in the use of mathematical methods. Now researchers in the majority of the population dynamics of ...the pest determinant of the two factors - dependent (regulator) and independent (modified), their density in accordance with the denomination. The Independent factors uniformly act on the pests, regardless of their number. This is mainly climatic factors. In contrast, a number of factors, depending on the density (within Amount competition, predators, parasites, diseases) enhance the scope of its activities, with an increase in the number of population. The process is described by differential equations containing nonlinear connections. In particular, we relied on the equations of Volterra-Lotka and Kolmogorov. As is known, it is impossible to find an analytical solution of such an equation and to conduct a qualitative analysis using phase portraits.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Abstract
Galactose-specific lectins (Gal-lectins) were isolated from the mitochondrial fraction of prostate post-operational hyperplasic tissue of two diagnoses: benign prostate hyperplasic tissue ...with low-grade intraepithelial neoplasia (LGPIN) and benign prostate hyperplasic tissue with atypical adenomatous hyperplasia (AAH). They had similar molecular weight and other properties. Effects of these lectins were investigated in vitro model experiments on bovine liver cells mitochondrial properties. Time-dependent changes: (i) in the amount of H2O2; (ii) redox state of Cu in cytochrome oxidase and (iii) redox state of heme in cytochrome a+a3 (cyt a+a3) of cytochrome c oxidase complex were studied. Gal-lectins from both sources increase the amount of H2O2 and decrease the redox state of Cu in cytochrome oxidase and heme in cyt a+a3. However the Gallectin from tissue with more severed transformation (AAH) expresses significantly more strong and long-lasting influence. These effects are mediated by galactose binding domain of the lectins as are completely abolished by the inclusion of galactose in reaction medium. Accumulation of H2O2 and long-lasting decrease in the redox state of key enzymes of mitochondrial respiration chain could induce defective functioning of these organelles and whole cells. Obtained data point the possible way, which enhances further transformation of prostate tissue by release of Gallectins from damaged mitochondria.
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DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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