ABSTRACT
Strong atmospheric escape has been detected in several close-in exoplanets. As these planets consist mostly of hydrogen, observations in hydrogen lines, such as Ly α and H α, are powerful ...diagnostics of escape. Here, we simulate the evolution of atmospheric escape of close-in giant planets and calculate their associated Ly α and H α transits. We use a 1D hydrodynamic escape model to compute physical properties of the atmosphere and a ray tracing technique to simulate spectroscopic transits. We consider giant (0.3 and 1 Mjup) planets orbiting a solar-like star at 0.045 au, evolving from 10 to 5000 Myr. We find that younger giants show higher rates of escape, owing to a favourable combination of higher irradiation fluxes and weaker gravities. Less massive planets show higher escape rates (1010–1013 g s−1) than those more massive (109–1012 g s−1) over their evolution. We estimate that the 1-Mjup planet would lose at most 1 per cent of its initial mass due to escape, while the 0.3-Mjup planet, could lose up to 20 per cent. This supports the idea that the Neptunian desert has been formed due to significant mass-loss in low-gravity planets. At younger ages, we find that the mid-transit Ly α line is saturated at line centre, while H α exhibits transit depths of at most 3–4 per cent in excess of their geometric transit. While at older ages, Ly α absorption is still significant (and possibly saturated for the lower mass planet), the H α absorption nearly disappears. This is because the extended atmosphere of neutral hydrogen becomes predominantly in the ground state after ∼1.2 Gyr.
Outcomes of Meaningful Work: A Meta‐Analysis Allan, Blake A.; Batz-Barbarich, Cassondra; Sterling, Haley M. ...
Journal of management studies,
20/May , Volume:
56, Issue:
3
Journal Article
Peer reviewed
Using job characteristics theory as a framework, we calculated meta‐analytic effect sizes between meaningful work and various outcomes and tested a mediated model of meaningful work predicting ...proximal and distal outcomes with meta‐analytic structural equation modelling (MASEM). From 44 articles (N = 23,144), we found that meaningful work had large correlations (r = 0.70+) with work engagement, commitment, and job satisfaction; moderate to large correlations (r = 0.44 to −0.49) with life satisfaction, life meaning, general health, and withdrawal intentions; and small to moderate correlations (r = −0.19 to 0.33) with organizational citizenship behaviours, self‐rated job performance, and negative affect. The best MASEM fitting model was meaningful work predicting work engagement, commitment, and job satisfaction and these variables subsequently predicting self‐rated performance, organizational citizenship behaviours, and withdrawal intentions. This meta‐analysis provides estimated effect sizes between meaningful work and its outcomes and reveals how meaningful work relates directly and indirectly to key outcomes.
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•An unprecedented number of peptide therapeutics have recently been approved.•Clinical pipeline analysis reveals an emphasis on peptides with enhanced properties.•Development of innovative ...glucagon-like peptide (GLP)-1 receptor agonists is a strong growth area.•Peptide–drug conjugates and constrained peptides hold promise as new therapeutics.
The notable expansion of peptide therapeutics development in the late 1990s and the 2000s led to an unprecedented number of marketing approvals in 2012 and has provided a robust pipeline that should deliver numerous approvals during the remainder of the 2010s. To document the current status of the pipeline, we collected data for peptide therapeutics in clinical studies and regulatory review, as well as those recently approved. In this Foundation review, we provide an overview of the pipeline, including therapeutic area and molecular targets, with a focus on glucagon-like peptide 1 receptor agonists. Areas for potential expansion, for example constrained peptides and peptide–drug conjugates, are profiled.
The unprecedented number of marketing approvals in 2012 for peptide therapeutics could be a harbinger for the innovative peptide-based drugs in the clinical pipeline.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
This essay represents the collective vision of a group of scholars in vocational psychology who have sought to develop a research agenda in response to the massive global unemployment crisis that has ...been evoked by the COVID-19 pandemic. The research agenda includes exploring how this unemployment crisis may differ from previous unemployment periods; examining the nature of the grief evoked by the parallel loss of work and loss of life; recognizing and addressing the privilege of scholars; examining the inequality that underlies the disproportionate impact of the crisis on poor and working class communities; developing a framework for evidence-based interventions for unemployed individuals; and examining the work-family interface and unemployment among youth.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Drawing on diverse examples from literature, film, memoirs, and popular culture, Men, Masculinities, and Infertilities analyses cultural representations of male infertility. Going beyond the ...biomedical and sociological towards interdisciplinary cultural studies, this book studies depictions of men’s infertility. It includes fictional representations alongside memoirs, newspaper articles, ethnographies and autoethnographies, and scientific reporting. Works under discussion range from twentieth-century novel Lady Chatterley's Lover to romantic comedy film Not Suitable For Children, and science fiction classic Mr Adam, as well as encompassing genres including blockbuster romance and memoir. Men, Masculinities, and Infertilities draws upon both sociological and popular culture research to trace how the discourse of cultural anxiety unfolds across disciplines. This engaging work will be of key interest to scholars of popular culture studies, gender and women’s studies (including queer and sexuality studies), critical studies of men and masculinities, cultural studies, and literary studies.
Background
Colorectal cancer (CRC) incidence is increasing in adults younger than 50 years. This study evaluated clinical and molecular features to identify those features unique to early‐onset CRC ...that differentiate these patients from patients 50 years old or older.
Methods
Baseline characteristics were evaluated according to the CRC onset age with 3 independent cohorts. A fourth cohort was used to describe the impact of age on the consensus molecular subtype (CMS) prevalence.
Results
This retrospective review of more than 36,000 patients with CRC showed that early‐onset patients were more likely to have microsatellite instability (P = .038), synchronous metastatic disease (P = .009), primary tumors in the distal colon or rectum (P < .0001), and fewer BRAF V600 mutations (P < .001) in comparison with patients 50 years old or older. Patients aged 18 to 29 years had fewer adenomatous polyposis coli (APC) mutations (odds ratio OR, 0.56; 95% confidence interval CI, 0.35‐0.90; P = .015) and an increased prevalence of signet ring histology (OR, 4.89; 95% CI, 3.23‐7.39; P < .0001) in comparison with other patients younger than 50 years. In patients younger than 40 years, CMS1 was the most common subtype, whereas CMS3 and CMS4 were uncommon (P = .003). CMS2 was relatively stable across age groups. Early‐onset patients with inflammatory bowel disease were more likely to have mucinous or signet ring histology (OR, 5.54; 95% CI, 2.24‐13.74; P = .0004) and less likely to have APC mutations (OR, 0.24; 95% CI, 0.07‐0.75; P = .019) in comparison with early‐onset patients without predisposing conditions.
Conclusions
Early‐onset CRC is not only distinct from traditional CRC: special consideration should be given to and further investigations should be performed for both very young patients with CRC (18‐29 years) and those with predisposing conditions. The etiology of the high rate of CMS1 in patients younger than 40 years deserves further exploration.
Early‐onset colorectal cancer (at an age <50 years) has distinct clinical and molecular features, including increased prevalences of synchronous metastatic disease, microsatellite instability, primary tumors located in the distal colon or rectum, and consensus molecular subtype 1 and fewer mutations in BRAF V600, in comparison with colorectal cancer in patients older than 50 years. Among patients with early‐onset colorectal cancer, those aged 18 to 29 years and those with predisposing conditions are distinct from the other patients younger than 50 years, and this suggests that considering all patients with colorectal cancer younger than 50 years together may not be appropriate.
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Colorectal cancers are classified as right/left-sided based on whether they occur before/after the splenic flexure, with established differences in molecular subtypes and outcomes. However, it is ...unclear if this division is optimal and whether precise tumor location provides further information.
In 1,876 patients with colorectal cancer, we compared mutation prevalence and overall survival (OS) according to side and location. Consensus molecular subtype (CMS) was compared in a separate cohort of 608 patients.
Mutation prevalence differed by side and location for
, and
Within left- and right-sided tumors, there remained substantial variations in mutation rates. For example, within right-sided tumors,
mutations decreased from 70% for cecal, to 43% for hepatic flexure location (
= 0.0001), while
V600 mutations increased from 10% to 22% between the same locations (
< 0.0001). Within left-sided tumors, the sigmoid and rectal region had more
mutations (
= 0.027), less
(
= 0.0009),
(
= 0.0033), or
mutations (
< 0.0001), and less MSI (
< 0.0001) than other left-sided locations. Despite this, a left/right division preceding the transverse colon maximized prognostic differences by side and transverse colon tumors had K-modes mutation clustering that appeared more left than right sided. CMS profiles showed a decline in CMS1 and CMS3 and rise in CMS2 prevalence moving distally.
Current right/left classifications may not fully recapitulate regional variations in tumor biology. Specifically, the sigmoid-rectal region appears unique and the transverse colon is distinct from other right-sided locations.
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Through earnings announcements, conference calls, and other press releases, corporate executives have an opportunity to frame the narrative of financial disclosures. Numerous studies have shown that ...textual tone significantly influences stock returns, suggesting that through word choice, upper management may impact market reaction. In this study, we examine the influence of CEO personality traits on corporate disclosures by analyzing the tone of earnings announcements for a sample of Fortune 500 CEOs over nearly two decades. Our hypotheses are twofold: (1) that qualitative disclosures in firms with narcissistic leaders will be biased upward and (2) the bias will moderate as CEOs becomes older. Our empirical results support these hypotheses and suggest that more narcissistic CEOs tend to reinforce their grandiose self-image by issuing more positive earnings announcements but this desire wanes with CEO age. We also find that the stock market response to the tone of the earnings announcement is less pronounced for more narcissistic CEOs, suggesting the market takes into account the bias in narcissistic CEO announcements.
Converging forces have led to an increase in precarious work, which threatens the health and well-being of workers globally and in the United States. Scholars in many fields are studying the ...implications of precarious work, and work psychologists have contributed to this literature by studying constructs such as job insecurity, underemployment, and decent work. In this article, we summarize the literature on precarious work and offer a psychological framework of work precarity to connect this psychological research with the existing precarious work literature. In the work precarity framework, social and economic marginalization and economic conditions and policies influence who has precarious work, which subsequently leads to three psychological states of work precarity: precarity of work (i.e., uncertainty related to the continuity of one's work), precarity at work (i.e., unpredictability in work due to discrimination, harassment, and unsafe working conditions), and precarity from work (i.e., uncertainty from holding a job that does not meet one's basic needs). These psychological states then result in poorer job attitudes, poorer mental health, and disrupted identity. We also provide future directions for research in this area and identify areas where work psychologists can contribute and advance the literature.
•Summarized the precarious work literature and context of the problem•Introduced precarity of work, precarity at work, and precarity from work•Proposed the work precarity framework to organize research in this area•Provided directions for future research on precarious work
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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