We carried out a controlled clinical trial to examine the potential of baclofen to slow the functional decline of patients with early Huntington's disease (HD). The basis of the trial was: (1) the ...hypothesis that excitatory amino acid neurotransmission mediates the neuronal degeneration of HD, (2) preclinical evidence that baclofen retards corticostriatal release of glutamate and aspartate, and (3) reports that baclofen produces short-term clinical benefits in some HD patients. Sixty patients with early HD were randomized to chronic baclofen, 60 mg/day, or placebo treatments and followed systematically for up to 42 months. Total functional capacity was not favorably influenced by baclofen treatment. Factors that contributed, although nonsignificantly, to a more rapid rate of total functional capacity decline included younger age (less than 35 years), earlier stage (stage I) of illness, paternal inheritance of the HD gene, and baclofen treatment. Our patients declined at a pace slower than that observed in other prospective studies, a finding likely due to selection criteria, avoidance of neuroleptic therapy, and strong psychosocial support.
A major modification of the refrigeration plant and heat exchanger at the NASA Glenn Icing Research Tunnel (IRT) occurred in autumn of 2011. It is standard practice at NASA Glenn to perform a full ...aero-thermal calibration of the test section of a wind tunnel facility upon completion of major modifications. This paper will discuss the tools and techniques used to complete an aero-thermal calibration of the IRT and the results that were acquired. The goal of this test entry was to complete a flow quality survey and aero-thermal calibration measurements in the test section of the IRT. Test hardware that was used includes the 2D Resistive Temperature Detector (RTD) array, 9-ft pressure survey rake, hot wire survey rake, and the quick check survey rake. This test hardware provides a map of the velocity, Mach number, total and static pressure, total temperature, flow angle and turbulence intensity. The data acquired were then reduced to examine pressure, temperature, velocity, flow angle, and turbulence intensity. Reduced data has been evaluated to assess how the facility meets flow quality goals. No icing conditions were tested as part of the aero-thermal calibration. However, the effects of the spray bar air injections on the flow quality and aero-thermal calibration measurements were examined as part of this calibration.
Attributions and Attribution-Behavior Relations Allen, Judith L; Walker, Lydia D; Schroeder, David A ...
Journal of personality and social psychology,
06/1987, Volume:
52, Issue:
6
Journal Article
Peer reviewed
We conducted two studies investigating level of cognitive development as a limiting factor for making valid causal attributions and using attributions as guides for subsequent behavior. Experiment 1 ...found that only subjects operating at a postconcrete level of cognitive development could reliably make valid causal attributions to explain others' performances on an achievement task. Experiment 2 found that even when the attributional task was simplified so that all subjects were able to make accurate attributions, only subjects at the formal-operational level showed a consistent relation between attributions and behavioral prescriptions intended to improve subsequent performance.
Full text
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CEKLJ, FFLJ, NUK, ODKLJ, PEFLJ, UPUK
Presents evidence of the migratory patterns of humpback whales (Megaptera novaeangliae) between the high-latitude feeding areas in the region of the Antarctic Peninsula and the low-latitude breeding ...and calving areas along the eastern and western margins of South America. Shows results based upon movements of individual whales identified by natural markings as part of a large-scale international collaboration. Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons Attribution 3.0 New Zealand Licence.
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