The on-line monitoring of a styrene/butadiene latex emulsion polymerization was completed. Our aim was to determine in real time the dry extract percentage or the amount of styrene monomer in the ...reactor. We constructed two partial least-squares (PLS) calibration models with mean-centered spectra over the 3500–2700 U 1800–500 cm−1 spectral range. Four factors were required to model the evolution of the dry extract, and a two-factors model calibrated the amount of free styrene. The results were very satisfactory: the dry extract was predicted with a root mean squared error of prediction (RMSEP) lower than 1% over the 2–50% dry extract range, and for the amount of styrene monomer, the RMSEP was lower than 5000 ppm over the 0–70 000 ppm range. The nonlinear effects of temperature and water reabsorption were considered, and they did not prevent PLS from giving good-quality results.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
We update our CHEP06 2 presentation on the ATLAS experiment software infrastructure used to build, validate, distribute, and document the ATLAS offline software. The ATLAS collaboration's ...computational resources and software developers are distributed around the globe in about 35 counties. The ATLAS offline code base is currently over 7 million source lines of code in 10,000+ C++ classes organized into about 2,000 packages. More than 400 developers contribute code each month. Since our last report, we have developed a powerful, flexible system to request code versions to be included in software builds, made changes to our software building tools, increased the number of daily builds used to validate significant code changes, improved the tools for distributing the code to our computational sites around the world, and made many advancements in the tools to document the code.
BACKGROUND: In women with chronic anovulation, the choice of the FSH starting dose and the modality of subsequent dose adjustments are critical in controlling the risk of overstimulation. The aim of ...this prospective randomized study was to assess the efficacy and safety of a decremental FSH dose regimen applied once the leading follicle was 10–13 mm in diameter in women treated for WHO Group II anovulation according to a chronic low-dose (CLD; 75 IU FSH for 14 days with 37.5 IU increment) step-up protocol. METHODS: Two hundred and nine subfertile women were treated with recombinant human FSH (r-hFSH) (Gonal-f) for ovulation induction according to a CLD step-up regimen. When the leading follicle reached a diameter of 10–13 mm, 158 participants were randomized by means of a computer-generated list to receive either the same FSH dose required to achieve the threshold for follicular development (CLD regimen) or half of this FSH dose sequential (SQ) regimen. HCG was administered only if not more than three follicles ≥16 mm in diameter were present and/or serum estradiol (E2) values were <1200 pg/ml. The primary outcome measure was the number of follicles ≥16 mm in size at the time of hCG administration. RESULTS: Clinical characteristics and ovarian parameters at the time of randomization were similar in the two groups. Both CLD and SQ protocols achieved similar follicular growth as regards the total number of follicles and medium-sized or mature follicles (≥16 mm: 1.5 ± 0.9 versus 1.4 ± 0.7, respectively). Furthermore, serum E2 levels were equivalent in the two groups at the time of hCG administration (441 ± 360 versus 425 ± 480 pg/ml for CLD and SQ protocols, respectively). The rate of mono-follicular development was identical as well as the percentage of patients who ovulated and achieved pregnancy. CONCLUSIONS: The results show that the CLD step-up regimen for FSH administration is efficacious and safe for promoting mono-follicular ovulation in women with WHO Group II anovulation. This study confirms that maintaining the same FSH starting dose for 14 days before increasing the dose in step-up regimen is critical to adequately control the risk of over-response. Strict application of CLD regimen should be recommended in women with WHO Group II anovulation.
We present the Fabry-Perot observations obtained for a new set of 108 galaxies in the frame of the Gassendi Halpha survey of SPirals (GHASP). The GHASP survey consists of 3D Halpha data cubes for 203 ...spiral and irregular galaxies, covering a large range in morphological types and absolute magnitudes, for kinematics analysis. The new set of data presented here completes the survey. The GHASP sample is by now the largest sample of Fabry-Perot data ever published. The analysis of the whole GHASP sample will be done in forthcoming papers. Using adaptive binning techniques based on Voronoi tessellations, we have derived Halpha data cubes from which are computed Halpha maps, radial velocity fields as well as residual velocity fields, position-velocity diagrams, rotation curves and the kinematical parameters for almost all galaxies. Original improvements in the determination of the kinematical parameters, rotation curves and their uncertainties have been implemented in the reduction procedure. This new method is based on the whole 2D velocity field and on the power spectrum of the residual velocity field rather than the classical method using successive crowns in the velocity field. Among the results, we point out that morphological position angles have systematically higher uncertainties than kinematical ones, especially for galaxies with low inclination. The morphological inclination of galaxies having no robust determination of their morphological position angle cannot be constrained correctly. Galaxies with high inclination show a better agreement between their kinematical inclination and their morphological inclination computed assuming a thin disc. The consistency of the velocity amplitude of our rotation curves has been checked using the Tully-Fisher relationship. Our data are in good agreement with previous determinations found in the literature. Nevertheless, galaxies with low inclination have statistically higher velocities than expected and fast rotators are less luminous than expected.
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BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
Ovarian cancer accounts for a minority of female cancers but remains the leading cause of death from gynaecologic cancers and the fifth leading cause of all cancer-related deaths among women. More ...than two thirds of cases of ovarian cancer are diagnosed once the disease becomes symptomatic, i.e. at an advanced stage. Though early detection constitutes a legitimate aim, no screening approach has yet been shown to reduce ovarian cancer mortality. In particular, ovarian imagery with endovaginal ultrasonography and serum tumor markers (CA-125) dosage performed in asymptomatic individuals have not proven their efficacy. Screening of asymptomatic women is not therefore recommended because of the limited prevalence of ovarian cancer in the general population.
Kinetics of Nitroxide Reaction with Iron(II) Bar-On, Pazit; Mohsen, Mohammad; Zhang, Renliang ...
Journal of the American Chemical Society,
09/1999, Volume:
121, Issue:
35
Journal Article
Peer reviewed
Like superoxide dismutase (SOD), nitroxide stable radicals can catalyze the dismutation of superoxide radicals and provide protection against oxidative stress. The SOD-mimic activity of nitroxides ...prompted the study of their biological effects; however, accumulated evidence suggested that the reactions of nitroxide with redox-active transition metals play an important role in its antioxidative activity. The present study concentrated on the kinetics of the reaction of iron(II) coordinated to various ligands with piperidinyl and pyrrolidinyl nitroxides nitroxide + H+ + Fe(II) hydroxylamine + Fe(III). The effects of pH, temperature, buffer, and ligands on the reaction kinetics were examined. UV−Vis absorption spectroscopy and electron paramagnetic resonance spectrometry were used to follow the change in the concentrations of iron and the nitroxide, respectively. The results show that under physiological conditions: (a) equilibrium 1 is shifted to the right; (b) OH- catalyzes the oxidation of iron and shifts the equilibrium further to the right; (c) phosphate, even at the submillimolar range, greatly catalyzes the reaction; and (d) piperidinyl nitroxides are more effective than pyrrolidinyl derivatives in oxidizing iron. The results imply that nitroxides rapidly and effectively oxidize iron, and most likely copper too, in the pool of chelatable redox-active metals in cells and tissues. This oxidation prevents the Fenton chemistry, suppresses the oxidative injury, and explains the narrow time-window anti-oxidative activity of nitroxides observed using cellular, animal, and organ experimental models.
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IJS, KILJ, NUK, PNG, UL, UM
This Letter presents the first search for supersymmetry in final states containing one isolated electron or muon, jets, and missing transverse momentum from sqrt{s} = 7 TeV proton-proton collisions ...at the LHC. The data were recorded by the ATLAS experiment during 2010 and correspond to a total integrated luminosity of 35 pb-1. No excess above the standard model background expectation is observed. Limits are set on the parameters of the minimal supergravity framework, extending previous limits. For A_0 = 0 GeV, tan beta = 3, mu > 0 and for equal squark and gluino masses, gluino masses below 700 GeV are excluded at 95% confidence level.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
The ATLAS detector is used to search for high-mass states, such as heavy charged gauge bosons (W', W*) decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on ...the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 36 pb-1. No excess beyond standard model expectations is observed. A W' with sequential standard model couplings is excluded at 95% confidence level for masses below 1.49 TeV, and a W*(charged chiral boson) for masses below 1.47 TeV.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Here we describe a new study of the SNRs and SNR candidates in nearby face-on spiral galaxy M83, based primarily on MUSE integral field spectroscopy. Our revised catalog of SNR candidates in M83 has ...366 objects, 81 of which are reported here for the first time. Of these, 229 lie within the MUSE observation region, 160 of which have spectra with SII:Halpha ratios exceeding 0.4, the value generally accepted as confirmation that an emission nebula is shock-heated. Combined with 51 SNR candidates outside the MUSE region with high SII:Halpha ratios, there are 211 spectroscopically-confirmed SNRs in M83, the largest number of confirmed SNRs in any external galaxy. MUSE's combination of relatively high spectral resolution and broad wavelength coverage has allowed us to explore two other properties of SNRs that could serve as the basis of future SNR searches. Specifically, most of the objects identified as SNRs on the basis of SII:Halpha ratios exhibit more velocity broadening and lower ratios of SIII:SII emission than HII regions. A search for nebulae with the very broad emission lines expected from young, rapidly expanding remnants revealed none, except for the previously identified B12-174a. The SNRs identified in M83 are, with few exceptions, middle-aged ISM-dominated ones. Smaller diameter candidates show a larger range of velocity broadening and a larger range of gas densities than the larger diameter objects, as expected if the SNRs expanding into denser gas brighten and then fade from view at smaller diameters than those expanding into a more tenuous ISM
The post-translational processing of peptides plays a key role in conferring biological activity on those peptides. Recently, ribosomally made peptides that contain D-amino acids at specific ...positions have been discovered in microorganisms as well as in vertebrates and invertebrates. This points to yet another strategy of circumventing stereochemical limitations imposed by the genetic code and conveying biological activity to otherwise inert molecules.
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