Senescence marker revisitedSearching for cells that express the p16INK4a tumor suppressor, which is often used as a marker of senescence during aging, Reyes et al. identified a population of ...fibroblasts within the stem cell niche in the lungs of young mice. When lung epithelial cells were injured with a toxic compound, they appeared to increase secretion and stimulate airway stem cells to regenerate the epithelium. The findings raise questions about whether all p16INK4a-expressing cells are senescent, and if strategies to remove such cells (because senescent cells can be harmful) could interfere with prevously unappreciated beneficial effects. —LBR
Purpose
In recent years there has been a noticeable increase in the use of advanced hybrid closed-loop systems (AHCLs) for managing type 1 diabetes (T1D) among youth. However, there is a lack of ...comparison between the open-source automated insulin delivery (AID) system and the MiniMed™ 780 G system (780 G).
Methods
In this multi-center study, we retrospectively compared selected glycemic ranges of 26 individuals who used open-source AID and 20 individuals who used 780 G (age 11.3 years IQR 9.3, 12.9 and 13.4 years IQR 10.9, 16.5, respectively,
p
= 0.069) from system initiation to the most recent visit.
Results
At baseline, the median HbA1c was significantly lower and the time below range (TBR)
<54mg/dL
was significantly higher in the open-source AID group compared to the 780 G group (6.8% IQR 6.4, 7.1 vs. 7.4% IQR 6.9, 8.6,
p
= 0.006 and (1.0% IQR 0.5, 2.8 vs. 0.0% 0.0, 1.0,
p
= 0.014), respectively; the median time in range (TIR
70–180mg/dL
) was similar (
p
= 0.068). After a median duration of 10.9 months on AHCLs the reduction of HbA1c was similar ( ~ 0.3%). The time spent in the hypoglycemic ranges was longer among users of the open-source AID compared to 780 G (TBR
54–70mg/dL
4.2% IQR 2.6, 7.3 vs. 2.0% 1.0, 4.0,
p
= 0.005) and TBR
<54mg/dL
1.1% IQR 0.4, 2.3 vs. 0.0 0.0, 1.0,
p
= 0.001).
Conclusions
Both AHCLs similarly improved HbA1c and TIR
70–180mg/dL
. The open-source AID youth had better glycemic control but spent longer time in the hypoglycemic range. These findings must be considered when choosing the use of AHCL technologies.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Purpose
The use of open-source automated insulin delivery systems (OS-AIDs), for the management of type 1 diabetes (T1D), has increased over recent years in all age groups. Real-life data has ...demonstrated the safety and efficacy of these systems, however, studies in the pediatric population remain limited. In this study, we aimed to examine the effect of transition to an OS-AIDs on glycemic parameters, and on several aspects related to quality of life. In addition, we aimed to characterize the socioeconomic position of families who chose this treatment modality, assess their motivations to do so, and evaluate treatment satisfaction.
Methods
In this multi-center observational real-life study from the AWeSoMe Group, we compared glycemic parameters of 52 individuals with T1D (56% males, mean diabetes duration 4.2 ± 3.9 years), from the last clinic visit prior to OS-AIDs initiation to the most recent clinic visit while using the system. Socioeconomic position (SEP) index was retrieved from the Israel Central Bureau of Statistics. Caregivers completed questionnaires assessing reasons for system initiation and treatment satisfaction.
Results
Mean age at OS-AIDs initiation was 11.2 ± 4 years, range 3.3–20.7 years with a median usage duration of 11.1 months (range 3–45.7). Mean SEP Index was 1.033 ± 0.956 (value range: −2.797 to 2.590). Time in range (TIR) of 70 to 180 mg/dl increased from 69.0 ± 11.9 to 75.5 ± 11.7%, (
P
< 0.001), and HbA1c decreased from 6.9 ± 0.7 to 6.4 ± 0.6%, (
P
< 0.001). Time in tight range (TITR) of 70 to 140 mg/dl increased from 49.7 ± 12.9 to 58.8 ± 10.8% (
P
< 0.001). No episodes of severe hypoglycemia or DKA were reported. Reduction in diabetes burden and sleep quality improvement were the main reasons for OS-AID initiation.
Conclusions
In our cohort of youth with T1D, the transition to an OS-AID resulted in greater TIR and less severe hypoglycemia regardless of age, diabetes duration or SEP, which was found to be above average. The overall improvement in glycemic parameters in our study population with excellent baseline glycemic control, provides additional evidence of beneficence and efficacy of OS-AIDs in the pediatric population.
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Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We engineered an ultrasensitive reporter of
, a biomarker of cellular senescence. Our reporter detected
-expressing fibroblasts with certain senescent characteristics that appeared shortly after ...birth in the basement membrane adjacent to epithelial stem cells in the lung. Furthermore, these
fibroblasts had enhanced capacity to sense tissue inflammation and respond through their increased secretory capacity to promote epithelial regeneration. In addition,
expression was required in fibroblasts to enhance epithelial regeneration. This study highlights a role for
fibroblasts as tissue-resident sentinels in the stem cell niche that monitor barrier integrity and rapidly respond to inflammation to promote tissue regeneration.
Studies of the relationship between explicit episodic memory of a traumatic event (MTE) and posttraumatic stress disorder (PTSD) are inconclusive. The authors examined whether memory for the details ...of the traumatic event as reported by patients with mild traumatic brain injury was associated with the development of PTSD. In a retrospective study of 120 participants, MTE was found to be associated with an increased risk of PTSD, particularly for the reexperiencing symptom cluster. Although less frequently, PTSD was nonetheless present even in the absence of explicit memory. Possible explanations for mechanisms that enable this phenomenon are considered.
Full text
Available for:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
