The aim of the present study was to determine species composition of ascidians and to detect the occurrence of alien ascidian species in İzmir Bay (Eastern Aegean Sea). The study was conducted at ...seven stations situated in recreational marinas and frequently used places for boating, fishing, and shipping activities in İzmir Bay between 25 and 27 August 2015 and between 23 and 26 November 2015. According to the findings, the non-native ascidian species such as Microcosmus squamiger Michaelsen, 1927, Didemnum ahu Monniot C. & Monniot F., 1987, and Polyclinum sp. were recorded for the first time on natural and artificial substrates at the sampling stations. The results indicate an increase in the number of alien ascidian species in the region. Also, the findings of this study showed that global marine invasive species M. squamiger has spread from the western Mediterranean to the eastern Mediterranean.
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BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Molecular modeling is used effectively in the fields of physics, biochemistry, molecular biology, drug design and interaction, synthesis of polymers and high quality new substances, both in research ...and industrial terms. Molecular modeling methods are of great importance in research, especially in theoretical studies. In this study, information is given about molecular modeling methods, molecular docking and molecular docking programs.
In this study, chemical composition and
in vitro
antibacterial and antifungal effects of essential oils extracted from fruit peel of
Citrus aurantium
L. grown in West Anatolian ecological conditions, ...were investigated. Antibacterial and antifungal activities were determined with the use of Minimum Inhibitory Concentration (MIC) method. Essential oils were obtained in a clevenger apparatus and their compositions were analysed by Gas Chromatography-Mass Spectrometry (GC-MS). According to the GC-MS results, dl-limonene (72.51%) and hexasiloxane (13.28%) were the major components in the essential oil obtained from
C. aurantium
Central population. Limonene (77.27%) and hexasiloxane (6.19%) dominated in the samples originated from Germencik region. Limonene (79.77%) was found to be in the highest concentration in the essential oil obtained from
C. aurantium
Koçarlı population. Limonene (95.70%) followed by β‑myrcene (0.76%) were the major components of the essential oil obtained from
Citrus aurantium
Nazilli population. MIC values ranged from 2.5 to 5 µL/mL for gram (−) bacteria and from 0.3125 to 5 µL/mL for gram (+) bacteria. Essential oil from Germencik region generally showed the best effect against fungi. Essential oil obtained from
Citrus aurantium
fruit peel could be an alternative to synthetic antimicrobial agents.
Background and Aims: The silver nanoparticles (Ag NPs) synthesized by green synthesis have antimicrobial properties and their potential to be used in the medical field is quite high. Puse, also ...called "black doctor", is widely used as a treatment for the health problems of animals and in folk medicine in Turkish nomad culture. It has been reported that Ag NPs biosynthesized with Juglansregia leaf extracts have antibacterial activity. The aim and importance of this study is the preparation of a mixture of "puse" and Ag NPs for the first time and the investigation of its antibacterial activity. Methods: In this paper, Ag NPs were synthesized by using J. regia leaves and morphological characteristics of the NPs obtained were determined using TEM. The formation of NPs was identified using an UV-Vis spectrophotometer. The antibacterial activity was investigated by combining the obtained and characterized Ag NPs with the "puse". The antibacterial activity of the mixture was tested on Gram (+) bacteria and Gram (-) bacter. Results: The mixture that was prepared with puse and Ag NPs showed higher antibacterial activity than antibiotics. Conclusion: The positive results showed that this mixture has the potential to be used as a preparation especially in the treatment of animal wounds and the skin infections caused by bacteria. Keywords: Biosynthesized, silver nanoparticles, antibacterial activity, Juglans regia, puse
The ground state optimized structures of some radical adducts of α-phenyl-N-tert-buthyl nitrone (PBN) in water and benzene solutions were calculated by using DFT (B3LYP, B3PW91 and PBEPBE) and HF ...methods with 6-311++G(d, p), 6-31G(d, p) and LanL2DZ levels. As trapped radicals, F, Cl, Br, H, OH, CN, NCO, and N3 were used. The calculated isotropic hyperfine coupling constants of all the trapped radicals were seen to be in good agreement with the corresponding experimental data. The hyperfine coupling constant due to the β proton of nitroxide radical was seen to be effected with the opposite spin density of oxygen nucleus bonded to the nitrogen. From all the calculated data it was concluded that for hyperfine calculations the DFT method is superior relative to the HF method. Also the geometrical parameters for the ground state optimized structures of all the radical adducts were listed, and the binding energies of all the trapped radicals were obtained.
Optimized structures of PBN–X spin adducts (X; F, Cl, Br, H, OH, CN, NCO, N3). Display omitted
•Optimized structures of some radical adducts of PBN were calculated.•DFT (B3LYP, B3PW91 and PBEPBE) and HF methods with 6-311++G(d, p), 6-31G(d, p) and LanL2DZ levels were used.•The variation of hfcc due to the β proton of nitrogen radical was investigated.•The binding energies of all the trapped radicals were obtained.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
This study was carried out with the aim of determining the antifungal effect of the essential oil isolated from Achillea millefolium subsp. millefolium plant against pathogenic fungi. In order to ...test the antifungal effect of the oil, an analysis was conducted on a total of 4 pathogen fungi which included Candida albicans, Candida tropicalis, Candida parapsilosis and Saccharomyces cerevisiae, and the effect of the essential oil on the growth of these fungi was investigated. The essential oil of A. millefolium ssp. millefolium had varying degrees of effect on the tested fungi. The highest antifungal effect was found against S. cerevisiae; whereas the lowest antifungal effect was found against C. parapsilosis. Nystatin showed a higher activity than the essential oil of A. millefolium subsp. millefolium against the tested fungi. MIC values of the essential oil against the tested fungi ranged from 1.25 μl/ml to 10 μl/ml. The results obtained indicate that essential oil of A. millefolium subsp. millefolium can be used as an alternative to antifungal agents such as amphotericin, ketoconazole, and fluconazole.
With more than 3.6 million Syrian refugees Turkey hosts the world's largest number of Syrians. Considering the morbidity, mortality, and healthcare spending, cancer is one of the leading health and ...economic burden for patients and healthcare systems. However, very limited information available in the scientific literature to understand the burden and characteristics of cancer in countries hosting Syrian refugees. The aim of the present study is to evaluate the demographic and clinical characteristics, treatment outcome of Syrian cancer patients living in Konya, Turkey.
We retrospectively reviewed medical records of Syrian cancer patients at three major institutions from 2005 to 2020. The information regarding demographic and clinical characteristics of patients were identified. The number of days between the first symptom and diagnosis was considered as the "diagnostic interval". Patients who failed to attend clinics within four weeks of appointment were assumed abandoned treatment. Survival curves were estimated using the Kaplan-Meier method.
We identified 230 adult and 38 children refugee diagnosed with cancer during the study period. With regards to adult patients, there were 114 (49.6%) male and 116 (50.4%) female. The median age at diagnosis was 52.4, 47.3 years for male, female respectively. The five most common cancer by site among all were; breast (24.8%), colorectal (10.9%), lung (7.4%), central nervous system (CNS) (7.0%), and stomach (5.2%). 93 (40.4%) had metastatic disease at diagnosis. The overall survival probability was 37.5% at five years for the adult population. Data were extracted for 20 boys and 18 girls with childhood cancer. Their median age at diagnosis was 5.8 and 6.0 years respectively. The three most common childhood cancer were; leukemias (21.1%), lymphomas (21.1%), and CNS (13.2%). Excluding leukemia, 13 (43.3%) of childhood cancer cases had the advanced disease at diagnosis. Three year survival probality was 69.5%. The median diagnostic interval for adult and childhood cancer was 96.5 (IQR = 53-165) and 23 (IQR = 13.5-59) days respectively. Twenty-one adults and four children had treatment abandonment.
This study contributes to understanding the burden of cancer among Syrian refugees living in Konya, growing health issue for refugees. Larger and prospective studies will help to measure the real burden and compare the difference in cancer risk factors, care, and outcomes among the refugee and host populations.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This paper presents anti-urease and antibacterial activities of chloropheniramine maleat, paracetamol and
clarithromycine. Antibacterial activity of the compounds was investigated against Salmonella ...enterica,
Enterobacter aerogenes, Bacillus subtilis, Proteus vulgaris, Gordonia rubripertincta, Klebsiella pneumoniae and
Enterococcus faecalis. Moreover, anti-urease activity of the compounds was searched. All tested compounds
demonstrated antibacterial action with varying degree except for chloropheniramine maleat. Chloropheniramine
maleat, paracetamol and chlarithromycine exhibited higher activity than thiourea. The data obtained from the
study, chloropheniramine maleate, paracetamol and clarithromycin are thought to be useful as new urease
inhibitors and the present study should be supported by further studies. Furthermore, it is thought that paracetamol
has antibacterial properties and therefore can be used as an alternative to antibiotics
Bu çalışmada klorofeniramin maleat, parasetamol ve klaritromisin’in antibakteriyal ve anti-üreaz aktiviteleri ile
ilgilenmektedir. Maddelerin antibakteriyal aktiviteleri Salmonella enterica, Enterobacter aerogenes, Bacillus
subtilis, Proteus vulgaris, Gordonia rubripertincta, Klebsiella pneumoniae, Bacillus megaterium ve Enterococcus
faecalis’e karşı araştırıldı. Bu maddelerin anti-üreaz aktiviteleri de incelendi. Klorofeniramin maleat dışında, test
edilen tüm bileşikler değişik oranlarda antibakteriyal etki gösterdi. Klorofeniramin maleat, parasetamol ve
klaritromisin tiyoüreden daha yüksek aktivite gösterdi. Çalışmadan elde edilen veriler, klorofeniramin maleat,
parasetamol ve klaritromisin yeni üreaz inhibitörü olarak kullanılabileceğini düşünülmüş olup mevcut çalışma
daha ileri çalışmalar ile de desteklenmelidir. Ayrıca, parasetamolün antibakteriyel özelliklere sahip olduğu ve bu
nedenle antibiyotiklere alternatif olarak kullanılabileceği düşünülmektedir.
Objective: Patients with type 2 diabetes have an increased tendency to develop hepatosteatosis. The effects of drugs used to treat diabetes on the
liver, regardless of the disease, are unknown.The ...aim of this study was to investigate the effects of vildagliptin, a dipeptidyl peptidase-4 inhibitor,
on the portal vein pressure and hepatosteatosis in patients with type 2 diabetes in the 18 months of follow-up.
Methods: Patients to whose treatment vildagliptin was added while they were on therapy with metformin and gliclazide for type 2 DM the
vildagliptin group were included. As the control group, 49 patients with type 2 DM treated with metformin and gliclazide were included. These
patients were followed up for 18 months. These patients were followed for 18 months and their pre-treatment and post-treatment examinations
were repeated. Portal vein diameter, portal vein flow and portal vein velocity were calculated to evaluate portal vein pressure with the same
Doppler ultrasonography (US) by the same radiologist. In the same session, the liver steatosis stage of all patients was evaluated with US and
recorded. The data before treatment and the data 18 months after treatment were compared.
Results: Nineteen patients completed the study in the study group, while 10 patients completed the study in the control group. A significant
increase in portal vein flow velocity and vein diameter was found in the study group when portal vein parameters were compared before and after
treatment (p=<0.001, p=0.035, respectively). There was no significant difference in portal vein flow volume. In the control group, no significant
changes in flow velocity and flow volume were detected, although there was a significant increase in portal vein diameter (p=0.04, p=0.07,
p=0.14, respectively). There were no significant changes in vildagliptin group before and after treatment in terms of hepatosteatosis (p=0.41).
There were no significant changes between control and study groups in terms of hepatosteatosis after 18 months of treatment.
Conclusion: As a result, we did not find any significant changes in the parameters of portal vein pressure with vildagliptin use. We think that
vildagliptin has no effect on hepatosteatosis.
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