Metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. However, the contribution of MetS to intermediate cardiovascular endpoints such as structure and function ...alterations of large arteries is still unclear.
A total of 917 middle-aged French men and women participating to the SUpplémentation en VItamines et Minéraux AntioXydants (SU.VI.MAX) Vascular study were included. Carotid-femoral pulse wave velocity was used to assess aortic stiffness. Carotid ultrasound examination included measurements (at sites free of plaques) of intima-media thickness (IMT) at the common carotid arteries (CCA) and assessment of atherosclerotic plaques in the extracranial carotid arteries.
Prevalence of the MetS defined by the National Cholesterol Education Program was 8.7%. Compared with subjects without MetS, subjects with MetS had significant higher mean values of CCA-IMT (
P = .02) and pulse wave velocity (
P = .0001). We found that MetS was not significantly related to the presence of carotid plaques. Blood pressure was the only MetS component associated with all vascular parameters. Addition of other MetS components in the multivariate models contributed poorly to the explained variance of these parameters.
The MetS is adversely associated with markers of early arterial dysfunction, such as CCA-IMT and arterial stiffness. Although the associations between MetS and these arterial parameters are related to insulin resistance, blood pressure was shown to be the most important MetS component in relation to structure and function of large arteries.
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GEOZS, IJS, NUK, OILJ, PNG, SBCE, UL, UM, UPUK
Objective: The objective of this study was to provide information on the prevalence of herpes simplex infections in the general population in Europe. Goals: The goals of this study were to determine ...the prevalence of clinically probable genital herpes and the relationship between serotype and clinical expression in a French community-based sample. Study: A total of 4410 subjects chosen at random were serotyped for herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2). Data on symptoms were obtained by questionnaire allowing retrospective diagnosis of clinically probable genital herpes. Results: Questionnaire data and serotype were available for 3192 subjects. Seroprevalences of HSV-1 and HSV-2 were 65.6% and 15.5%, respectively. Prevalence of clinically probable genital herpes was 11.8%, identified in 11.1% of HSV-1-positive subjects and 26.8% of HSV-2-positive subjects, with a lower prevalence in those coinfected with both virus types. Conclusions: Clinically probable genital herpes was observed in one fourth of subjects with HSV-2 infections and in some subjects with HSV-1 infection. Coinfection with HSV-1 appeared to protect against symptom expression in subjects infected with HSV-2.
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BFBNIB, NMLJ, NUK, PNG, UL, UM, UPUK
While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship.
To determine whether ...drinking patterns modulate the relationship between alcohol and cardiovascular risk factors.
We tested the relationship between preference of alcoholic beverages and atherosclerotic risk factors in a cross-sectional study of 2,126 men. A hierarchical clustering method determined six drinking patterns, 'low drinkers', 'high quality wines', 'beer and cider', 'digestives', 'local wines', and 'table wines', according to the preferential intake of alcoholic beverages. Logistic models estimated the relative risk of abnormal markers in the drinking patterns compared with low drinkers. Unadjusted estimates investigated the relationship with the cluster as a group, while adjustment on alcohol, nutritional and socio-demographic factors investigated the relationship with the preference of alcoholic beverage in itself.
Abstainers had high total plasma homocysteine (tHcy), even after full adjustment (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.8). Drinkers of high quality wine had low lipoprotein( a), high tHcy and high body mass index; beer and cider drinkers had high tHcy and waist circumference. Drinkers of digestives had high triacylglycerol; after adjustment they were at risk of low apolipoprotein A-I (OR = 3.1, 95% CI: 1.2, 7.3), and high tHcy (OR = 4.9, 95% CI: 1.2, 33.3). Local wines drinkers were similar to low drinkers. Table wine drinkers had high apolipoprotein B, high triacylglycerol, and high waist-to-hip ratio.
Our data suggest that preference of alcoholic beverage could indicate groups at specific risks of atherosclerotic disease.
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DOBA, EMUNI, FIS, FSPLJ, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Larroque et al investigated the relation between school difficulties and being born small for gestational age at full term in adolescents and young adults. The results show that small for gestational ...age at term is associated with poorer school performance at 12 years and 18 years.
PURPOSE: To assess the relationships between lipid levels and sexual maturity, independently of age-related differences, and to investigate possible differences related to sexual maturity across the ...percentiles of the lipid distributions.
METHODS: Fasting serum total cholesterol and triglyceride concentrations were measured in 6577 boys and 6605 girls, aged from 10 to 13 years, with different Tanner stages. The total cholesterol and triglyceride mean and percentile levels were estimated according to age and Tanner stage by ordinary least squares and percentile regression models, separately in both sexes.
RESULTS: In boys and girls, total cholesterol levels were significantly associated with pubertal stage after controlling for age. At age 12, the estimated mean levels in boys varied from 4.82 mmol/L for Tanner 1 to 4.41 for Tanner 5. The corresponding values were 5.05 and 4.62 mmol/L in girls, for whom the association with maturity was stronger in the upper than in the lower percentiles (
p < 0.0001); between the extreme Tanner stages, the 95th percentiles of total cholesterol differed by 0.80 mmol/L, in comparison to 0.19 mmol/L for the 5th percentiles. Therefore, 1.8% of girls and 0.7% of boys were classified differently whether Tanner stage was used or not to assess hypercholesterolemia (concentrations in the upper 5% of the distributions). Triglycerides were positively related to sexual maturity independently of age, but the discrepancies between classifications were lower; 1.1% in girls and 0.4% in boys.
CONCLUSIONS: Our findings emphasize the importance of sexual maturity, even for a given age, for interpreting lipid levels in children.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Previous studies on the effects of alcohol consumption on total plasma homocysteine (tHcy) concentrations showed contradictory results. The conflicting results may derive in part from confounding by ...the type of alcoholic beverage consumed.
The objective of the study was to evaluate in a predominantly wine-drinking French population whether the relation between alcohol consumption and homocysteine concentrations is dependent on the type of alcoholic beverage consumed.
In 1996, a cross-sectional study measuring tHcy and red blood cell folate concentrations was conducted in 1196 middle-aged women and men from the French Supplementation with Antioxidant Vitamins and Minerals Study. Intakes of alcohol, energy, coffee, and B vitamins were assessed by 6 separate 24-h dietary records from the previous year.
tHcy concentrations were positively associated with wine intake (P = 0.01) in the women and with beer intake in the men (P = 0.002). No association with the consumption of spirits was observed. The association between beer consumption and tHcy concentrations in the men was modified by the consumption of wine; the association was positive in wine drinkers, whereas an inverse trend was seen in those who drank no wine.
Wine consumption may increase tHcy concentrations, whereas beer consumption seems to have no effect (or even an inverse effect) on tHcy.
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CMK, GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Drinking patterns in French adult men Rouillier, Philippe; Boutron-Ruault, Marie-Christine; Bertrais, Sandrine ...
European journal of nutrition,
4/2004, Volume:
43, Issue:
2
Journal Article
Peer reviewed
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DOBA, EMUNI, FIS, FSPLJ, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Aims: The nutrient impact of ready-to-eat (RTE) cereal consumption was assessed in adults (men 45–60 years; women 35–60 years old) who regularly consumed RTE cereals anytime during the day, compared ...to those who did not or who were occasional eaters. Methods: Data were obtained for 2,188 men and 2,851 women living in France and participating in the SU.VI.MAX cohort, who reported twelve 24-hour dietary records during 2 years of follow-up (60,468 records). Results: In the heavy consumers group, RTE cereals provided 193 kcal/day for men and 168 kcal/day for women and contributed 8–10% of total daily energy intake; 15–17% of total daily carbohydrates intake; 4% of total daily lipids intake; 5–6% of total protein intake; and 19–23% of total fiber intake. Moreover, RTE cereals contributed 20–30% of total daily intake for vitamins B1, B2, B6 and folic acid, and 7% for vitamin B12. For minerals, they provided, respectively, for men and women, 22 and 25% of total daily intake for iron, 12 and 14% for magnesium, and 4% for calcium. In both genders, heavy consumers of RTE cereals derived a greater proportion of daily energy from carbohydrates and a lesser proportion of energy from fats. Total daily fiber intake is higher for RTE cereal consumers than for nonconsumers and increases with the frequency of consumption. Frequent consumers of RTE cereals have higher dietary intakes of calcium, magnesium, iron, vitamins B1, B2, B6, and folic acid than do nonconsumers. BMI and waist/hip ratio were significantly lower in heavy consumers of RTE cereals than in nonconsumers. Conclusion: The present data suggest that the consumption of RTE cereals contributes to a balanced diet. The strong association between cereal consumption and vitamin and mineral intakes confirm previous studies suggesting that RTE cereals make a major contribution to micronutrient intakes. The consumption of RTE cereals also appears to be associated with lower corpulence.
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The relationship of tea consumption with classical cardiovascular risk factors was evaluated. Cardiovascular risk factors were measured in 2926 participants of the SU.VI.MAX study (an ongoing ...intervention trial on the effects of antioxidant supplementation on chronic diseases), who completed six 24-hour dietary records in the year before. Analyses of variance were used in a cross-sectional design. In women, waist-hip ratio, total cholesterol, serum-triglycerides and fasting glucose decreased with increasing tea consumption, whereas, BMI, blood pressure and serum-triglycerides were related with tea consumption in men (p for trend between 0.002 and 0.05). Fruit and vegetable consumption increased, and consumption of meat, and coffee decreased with increasing tea consumption (p for trend ranged from 0.0001 to 0.04). Total fat intake was positively related to tea consumption (p for trend = 0.0005 in men and 0.0001 in women). Tea consumption may be important in evaluating determinants of cardiovascular risk, but lifestyle factors should be taken into account.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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