Here we report the applicability of a protocol based on clinical conditions and risk factors (RFs) for managing 35 allogeneic hematopoietic stem cell transplantation (allo‐HSCT) recipients who ...developed a total of 52 episodes of respiratory viral infections (RVIs) caused by respiratory syncytial virus (RSV; n=19), human parainfluenza virus (HPIV; n=29), or both (n=4) over a 2‐year study period. Risk categories were classified as high risk (cat‐1) when the immunodeficiency scoring index was ≥3 and/or ≥3 RFs and/or ≥1 co‐infective virus(es) were present; the remaining cases were classified as low risk (cat‐0). The presence of two or more signs or symptoms including fever (T>38 °C), sinusitis, otitis, sore throat, tonsillitis, or baseline C‐reactive protein increased by >2‐fold at the time of the RVI, was considered a clinically‐intense episode (CIE). Overall, 34 out of 52 episodes (65%) were limited to upper respiratory tract infections (URTIs). Overall, 26 (50%) received oral ribavirin. Twenty‐four of 40 (60%) cat‐1 episodes were treated, compared to 2 of 12 (17%) cat‐0 RVIs (P=.01), while 17 of the 25 (68%) CIEs were treated compared to 9 of the remaining 27 (33%) episodes (P=.02). Regardless of antiviral therapy, the overall resolution rate was 100% for URTI and 95% for lower respiratory tract infection; the virus‐related mortality was low (4%). In conclusion, the use of a risk‐adapted protocol to guide therapeutic decisions for allo‐HSCT recipients with RSV or HPIV RVIs is feasible and may limit unnecessary antiviral therapy.
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The aim of this short note is to completely answer Questions 2.34 and 2.35 of arXiv:1806.01127. In particular, we show that a finite strong-nil skew brace \(B\) of abelian type need not be ...right-nilpotent, but that this is the case if~\(B\) is of nilpotent type and \(b\ast b=0\) for all \(b\in B\) (our examples show that this is the best possible result).
The aim of this paper is to study supersoluble skew braces, a class of skew braces that encompasses all finite skew braces of square-free order. It turns out that finite supersoluble skew braces have ...Sylow towers, and that in an arbitrary supersoluble skew brace \(B\) many relevant skew brace-theoretical properties are easier to identify: for example, a centrally nilpotent ideal of \(B\) is \(B\)-centrally nilpotent, a fact that simplifies the computational search for the Fitting ideal; also, \(B\) has finite multipermutational level if and only if \((B,+)\) is nilpotent. Given a finite presentation of the structure skew brace \(G(X,r)\) associated with a finite non-degenerate solution of the Yang--Baxter Equation (YBE), there is an algorithm that decides if \(G(X,r)\) is supersoluble or not. Moreover, supersoluble skew braces are examples of almost polycyclic skew braces, so they give rise to solutions of the YBE on which one can algorithmically work on.
Nipotency of skew braces is related to certain types of solutions of the Yang-Baxter equation. This paper delves into the study of centrally nilpotent skew braces. In particular, we study their ...torsion theory (Section 4.1) and we introduce an "index" for subbraces (Section 4.2), but we also show that the product of centrally nilpotent ideals need not be centrally nilpotent (Example B), a rather peculiar fact. To cope with these examples, we introduce a special type of nilpotent ideal, using which, we define a {\it good} Fitting ideal. Also, a Frattini ideal is defined and its relationship with the Fitting ideal is investigated. A key ingredient in our work is the characterisation of the commutator of ideals in terms of absorbing polynomials (Section 3); this solves Problem 3.4 of arXiv:2109.04389. Moreover, we provide an example (Example A) showing that the idealiser of a subbrace (as defined in arXiv:2205.01572v2) does not exist in general.
In recent years, some epidemiologic studies have attributed adverse effects of air pollutants on health not only to particles and sulfur dioxide but also to photochemical air pollutants (nitrogen ...dioxide and ozone). The effects are usually small, leading to some inconsistencies in the results of the studies. Furthermore, the different methodologic approaches of the studies used has made it difficult to derive generic conclusions. We provide here a quantitative summary of the short-term effects of photochemical air pollutants on mortality in seven Spanish cities involved in the EMECAM project, using generalized additive models from analyses of single and multiple pollutants. Nitrogen dioxide and ozone data were provided by seven EMECAM cities (Barcelona, Gijón, Huelva, Madrid, Oviedo, Seville, and Valencia). Mortality indicators included daily total mortality from all causes excluding external causes, daily cardiovascular mortality, and daily respiratory mortality. Individual estimates, obtained from city-specific generalized additive Poisson autoregressive models, were combined by means of fixed effects models and, if significant heterogeneity among local estimates was found, also by random effects models. Significant positive associations were found between daily mortality (all causes and cardiovascular) and NO2, once the rest of air pollutants were taken into account. A 10 μ g/ m3increase in the 24-hr average 1-day NO2level was associated with an increase in the daily number of deaths of 0.43% 95% confidence interval (CI),-0.003-0.86% for all causes excluding external. In the case of significant relationships, relative risks for cause-specific mortality were nearly twice as much as that for total mortality for all the photochemical pollutants. Ozone was independently related only to cardiovascular daily mortality. No independent statistically significant relationship between photochemical air pollutants and respiratory mortality was found. The results in this study suggest that, given the present levels of photochemical pollutants, people living in Spanish cities are exposed to health risks derived from air pollution.
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