Background
Treatment of acute respiratory distress syndrome (ARDS) in children is largely based on extrapolated knowledge obtained from adults and which varies between different hospitals. This study ...explores ventilation treatment strategies for children with ARDS in the Nordic countries, and compares these with international practice.
Methods
In October 2012, a questionnaire covering ventilation treatment strategies for children aged 1 month to 6 years of age with ARDS was sent to 21 large Nordic intensive care units that treat children with ARDS. Pre‐terms and children with congenital conditions were excluded.
Results
Eighteen of the 21 (86%) targeted intensive care units responded to the questionnaire. Fifty per cent of these facilities were paediatric intensive care units. Written guidelines existed in 44% of the units. Fifty per cent of the units frequently used cuffed endotracheal tubes. Ventilation was achieved by pressure control for 89% vs. volume control for 11% of units. Bronchodilators were used by all units, whereas steroids usage was 83% and surfactant 39%. Inhaled nitric oxide and high frequency oscillation were available in 94% of the units. Neurally adjusted ventilator assist was used by 44% of the units. Extracorporeal membrane oxygenation could be started in 44% of the units.
Conclusion
Ventilation treatment strategies for paediatric ARDS in the Nordic countries are relatively uniform and largely in accordance with international practice. The use of steroids and surfactant is more frequent than shown in other studies.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Results We conducted simulations of the course of sepsis with the new version of the model and were able to observe nonintuitive effects of the incorporated aging-related changes on mortality rates ...for different age categories.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Using 3.3 pb−1 of data collected with the CMD-2 detector in the 720–840 MeV c.m. energy range, the branching fraction of the conversion decay ω→π0e+e− has been measured: ...B(ω→π0e+e−)=(8.19±0.71±0.62)×10−4. The upper limits for the branching fractions of the following conversion decays have been obtained at the 90% confidence level: B(ρ→π0e+e−)<1.6×10−5, B(ρ→ηe+e−)<0.7×10−5 and B(ω→ηe+e−)<1.1×10−5.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
By using this "ranking strategy", we were able to determine that although as few as 25 parameter changes could result in reasonable fits to calibration data, a larger number were likely needed for ...accurate predictions of inflammation in response to surgical trauma + hemorrhagic shock + resuscitation in rats following this limited recalibration procedure.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Failure to translate successful early-phase studies into registered therapeutics, the rising cost of large randomized clinical trials, the postmarketing discovery of catastrophic consequences of ...agents registered for human use, increased media and public scrutiny into the process of drug discovery, and the difficulties associated with identifying suitable lead compounds from high-throughput techniques are only some of the factors that are motivating researchers, registration agencies, and the pharmaceutical industry to question the very process of assessing therapeutic values of compounds or strategies in human disease.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Aging effects were modeled by altering the effectiveness of macrophages and neutrophils with respect to killing capacity, production of superoxide, tumor necrosis factor, interleukin 6, and their ...cell half-lives.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The innate immune response induced by these diverse insults is now thought to be driven by the recognition, through identical cell-surface molecules (the Toll-like receptors) of both pathogen-derived ...and (damaged) host-derived molecules that signal a state of "danger" to the host.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The updated results of the precise measurements of the processes e+e−→ρ→π+π−, e+e−→ω→π+π−π0 and e+e−→φ→K0LK0S performed by the CMD-2 Collaboration are presented. The update appeared necessary due to ...an overestimate of the integrated luminosity in previous analyses.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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