The role of cholesterol in bilayer and monolayer lipid membranes has been of great interest. On the biophysical front, cholesterol significantly increases the order of the lipid packing, lowers the ...membrane permeability, and maintains membrane fluidity by forming liquid-ordered–phase lipid rafts. However, direct observation of any influence on membrane chemistry related to these cholesterol-induced physical properties has been absent. Here we report that the addition of 30 mol % cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (POPG) monolayers at the air–water interface greatly reduces the oxidation and ester linkage cleavage chemistries initiated by potent chemicals such as OH radicals and HCl vapor, respectively. These results shed light on the indispensable chemoprotective function of cholesterol in lipid membranes. Another significant finding is that OH oxidation of unsaturated lipids generates Criegee intermediate, which is an important radical involved in many atmospheric processes.
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BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
Recent surveys of protoplanetary disks show that substructure in dust thermal continuum emission maps is common in protoplanetary disks. These substructures, most prominently rings and gaps, shape ...and change the chemical and physical conditions of the disk, along with the dust size distributions. In this work, we use a thermochemical code to focus on the chemical evolution that is occurring within the gas-depleted gap and the dust-rich ring often observed behind it. The compositions of these spatial locations are of great import, as the gas and ice-coated grains will end up being part of the atmospheres of gas giants and/or the seeds of rocky planets. Our models show that the dust temperature at the midplane of the gap increases, enough to produce local sublimation of key volatiles and pushing the molecular layer closer to the midplane, while it decreases in the dust-rich ring, causing a higher volatile deposition onto the dust grain surfaces. Further, the ring itself presents a freeze-out trap for volatiles in local flows powered by forming planets, becoming a site of localized volatile enhancement. Within the gas-depleted gap, the line emission depends on several different parameters, such as the depth of the gap in surface density, the location of the dust substructure, and the abundance of common gas tracers, such as CO. In order to break this uncertainty between abundance and surface density, other methods, such as disk kinematics, become necessary to constrain the disk structure and its chemical evolution.
Context. Transition disks offer the extraordinary opportunity to look for newly born planets and to investigate the early stages of planet formation. Aim. In this context we observed the Herbig A5 ...star MWC 758 with the L′-band vector vortex coronagraph installed in the near-infrared camera and spectrograph NIRC2 at the Keck II telescope, with the aim of unveiling the nature of the spiral structure by constraining the presence of planetary companions in the system. Methods. Our high-contrast imaging observations show a bright (ΔL′ = 7.0 ± 0.3 mag) point-like emission south of MWC 758 at a deprojected separation of ~20 au (r = 0.′′111 ± 0.′′004) from the central star. We also recover the two spiral arms (southeast and northwest), already imaged by previous studies in polarized light, and discover a third arm to the southwest of the star. No additional companions were detected in the system down to 5 Jupiter masses beyond 0.′′6 from the star. Results. We propose that the bright L′-band emission could be caused by the presence of an embedded and accreting protoplanet, although the possibility of it being an asymmetric disk feature cannot be excluded. The spiral structure is probably not related to the protoplanet candidate, unless on an inclined and eccentric orbit, and it could be due to one (or more) yet undetected planetary companions at the edge of or outside the spiral pattern. Future observations and additional simulations will be needed to shed light on the true nature of the point-like source and its link with the spiral arms.
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During in vitro maturation (IVM), the compact structure of cumulus-oocyte complexes (COCs) is vital for oocyte competence acquisition. Intermedin/Adrenomedullin-2 (IMD/ADM2) binds to the receptor ...RAMP (1, 2, or 3):CLR. Recently, it was demonstrated that IMD/ADM2 stimulates oocyte competence and improves bovine embryo quality. Therefore, this study aimed to examine the IMD/ADM2 as a secretory factor controlling COCs conformation for oocyte maturation. The results showed that traditional M-CDM medium induced in COCs the
Imd/Adm2
gene expression during IVM and produced IMD/ADM2 peptide secretion. Furthermore, after IVM, in the oocytes, the expression of
ramps
(1, 2, or 3) and
clr
was demolished, and RAMPs and CLR proteins were decreased, with a negative Pearson correlation. These results suggest that RAMPs and CLR are synthesized and stored during oocyte maturation. Supplementing the M-CDM with α-RAMP1 or α-IMD/ADM2 antibodies elicits a negative effect (
P
< 0.05) in COCs compaction. Blocking the IMD/ADM2 signaling pathway with any α-RAMPs or α-CLR antibodies produces a similar lower yield of oocytes in metaphase II (
P
> 0.05) but was lower than control culture medium (
P
< 0.05). In conclusion, when COCs are cultured with M-CDM, the IMD/ADM2 becomes expressed and secreted. In turn, it acts as a ligand preferentially to RAMP1:CLR or RAMP3:CLR, present in cumulus cells and oocytes. Sequentially, COCs compact structure is conformed to promote an adequate bidirectional communication that conduces the oocytes’ maturation.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Gas and aqueous phases are essential media for atmospheric chemistry and aerosol formation. Numerous studies have focused on aqueous-phase reactions as well as coupled gas/aqueous-phase mass ...transport and reaction. Few studies have directly addressed processes occurring at the air–water interface, especially involving surface-active compounds. We report here the application of field-induced droplet ionization mass spectrometry (FIDI-MS) to chemical reactions occurring at the atmospheric air–water interface. We determine the air–water interfacial OH radical reaction rate constants for sodium dodecyl sulfate (SDS), a common surfactant, and pinonic acid (PA), a surface-active species and proxy for biogenic atmospheric oxidation products, as 2.87 × 10–8 and 9.38 × 10–8 cm2 molec–1 s–1, respectively. In support of the experimental data, a comprehensive gas-surface-aqueous multiphase transport and reaction model of general applicability to atmospheric interfacial processes is developed. Through application of the model, PA is shown to be oxidized exclusively at the air–water interface of droplets with a diameter of 5 μm under typical ambient OH levels. In the absence of interfacial reaction, aqueous- rather than gas-phase oxidation is the major PA sink. We demonstrate the critical importance of air–water interfacial chemistry in determining the fate of surface-active species.
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IJS, KILJ, NUK, PNG, UL, UM
Context.
In recent years, protoplanetary disks with spiral structures have been detected in scattered light, millimeter continuum, and CO gas emission. The mechanisms causing these structures are ...still under debate. A popular scenario to drive the spiral arms is the one of a planet perturbing the material in the disk. However, if the disk is massive, gravitational instability isusually the favored explanation. Multiwavelength studies could be helpful to distinguish between the two scenarios. So far, only a handful of disks with spiral arms have been observed in both scattered light and millimeter continuum.
Aims.
We aim to perform an in-depth characterization of the protoplanetary disk morphology around WaOph 6 analyzing data obtained at different wavelengths, as well as to investigate the origin of the spiral features in the disk.
Methods.
We present the first near-infrared polarimetric observations of WaOph 6 obtained with SPHERE at the VLT and compare them to archival millimeter continuum ALMA observations. We traced the spiral features in both data sets and estimated the respective pitch angles. We discuss the different scenarios that can give rise to the spiral arms in WaOph 6. We tested the planetary perturber hypothesis by performing hydrodynamical and radiative transfer simulations to compare them with scattered light and millimeter continuum observations.
Results.
We confirm that the spiral structure is present in our polarized scattered light
H
-band observationsof WaOph 6, making it the youngest disk with spiral arms detected at these wavelengths. From the comparison to the millimeter ALMA-DSHARP observations, we confirm that the disk is flared. We explore the possibility of a massive planetary perturber driving the spiral arms by running hydrodynamical and radiative transfer simulations, and we find that a planet of minimum 10
M
Jup
outside of the observed spiral structure is able to drive spiral arms that resemble the ones in the observations. We derive detection limits from our SPHERE observations and get estimates of the planet’s contrast from different evolutionary models.
Conclusions.
Up to now, no spiral arms had been observed in scattered light in disks around K and/or M stars with ages <1 Myr. Future observations of WaOph 6 could allow us to test theoretical predictions for planet evolutionary models, as well as give us more insightinto the mechanisms driving the spiral arms.
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In this paper, a Weibull probabilistic methodology is proposed with an approach to model vibration fatigue damage accumulation using two parameters: Weibull distribution and a nonlinear fatigue ...damage accumulation model. The damage is cumulated based on the application of a vibration stress profile and is used to determine both the Weibull β and η parameters, and the corresponding component reliability R(t). The vibration fatigue damage is analyzed to accumulate the damage as a stress function for a fatigue life exponent derived with the assistance of the acceleration’s force response. The steps to determine the Weibull β and η parameters are estimated based only on the principal vibration stresses σ1 and σ2 that allow the reproduction of the vibration fatigue damage. The method’s efficiency is based on the probabilistic approach by using the vibration fatigue damage as the Yi vector that covers the arithmetic mean as well as the β parameter. Finally, the procedure proposed is applied in a practical case where a mechanical component is used as a support for telecommunication connections and is submitted to vibration stress. The results show that using the damage accumulated as the Yi vector to estimate the parameters allows for the analysis of dynamic and individual applications.
OBJECTIVES:To assess the correlation of true nonenhanced (TNE) and virtually nonenhanced (VNE) images of abdominal dual-energy computed tomography (DECT) in patients with metastatic gastrointestinal ...stromal tumors (GIST), and further to investigate the correlation of iodine-related attenuation (IRA) of DECT with the Choi criteria.
MATERIAL AND METHODS:Twenty-four consecutive patients (5 women aged 61 ± 10 years) with metastatic GIST underwent DECT of the abdomen (80 kV, 140 kV) using first-generation dual-source computed tomography (CT). All patients had at least one or more liver lesions (median, 4; maximum, 9). Image data were processed with a dedicated DECT software algorithm designed for evaluation of iodine distribution in soft tissue lesions, and VNE CT images were generated. The tumor density (according to Choi criteria) and the maximum transverse diameter of the lesions (according to Response Evaluation Criteria in Solid Tumors RECIST) were determined. TNE and VNE lesion attenuation and Choi criteria and IRA were correlated with each other.
RESULTS:A total of 291 liver lesions were evaluated, of which 220 were cystic and 71 were solid. The mean lesion size was 4.5 ± 3.2 cm (1.1–18.7 cm). The mean attenuation of all lesions was significantly higher in the TNE images than in the VNE images (P=0.0001). Pearson statistics revealed an excellent correlation of r=0.843 (P=0.0001) between IRA and Choi criteria for all lesions. DECT showed significantly higher IRA in progressive (23.3 ± 9.5 HU) lesions compared with stable or regressive (17.8 ± 9.1 HU) lesions (P=0.0185). Similarly, the Choi criteria differed significantly between progressive (39.9 ± 12.8 HU) and stable/regressive (31.1 ± 10.3 HU) lesions (P=0.0003).
CONCLUSIONS:DECT is a promising imaging method for the assessment of treatment response in GIST, as IRA might be a more robust response parameter than the Choi criteria. VNE CT data calculated from DECT may eliminate the need for acquisition of a separate unenhanced data set.
In this paper, the formulation to incorporate the used vibration profile, the stress generated by the product’s application, mass, and the resonance frequency is given. After that, based on the ...vibration output data, the two-parameter Weibull distribution is used to predict the corresponding reliability indices. In the method, the mentioned stress is incorporated as acceleration response (Ares), and by using a dynamic stress factor (σdyn). In addition, the Weibull parameters are determined based on the generated maximum and minimum principal vibration stress values. In the paper we show the efficiency of the fitted Weibull distribution to predict the reliability indices, by using its Weibull shape and scale parameters, it is always possible to reproduce the principal vibration stress values. Additionally, from the numerical application, we show how to use the Weibull analysis to determine the reliability index for a desired stress or desired cycle value. Finally, we also present the guidelines to apply the proposed method to any vibration fatigue analysis where the Ares (used to determine the σ1 and σ2 values), and the σdyn value are both known.
This study was conducted from a perspective that adopts a broad vision of mathematical talent, defined as the potential that a subject manifests when confronting certain types of tasks, in a ...successful way, that generate creative mathematical activity. To analyse this, our study proposes a Praxeological Model of Mathematical Talent based on the Anthropological Theory of Didactics and the notion of mathematical creativity, which defines four technological functions: (1) producing new techniques; (2) optimizing those techniques (3); considering tasks from diverse angles; and (4) adapting techniques. Using this model, this study analyses the creative mathematical activity of students aged 10–12 years displayed as they sought to solve a series of infinite succession tasks proposed to encourage the construction of generalization processes. The setting is a Mathematics Club (a talent-promoting institution). The evaluation of results shows that the Praxeological Model of Mathematical Talent allows the emergence and analysis of mathematical creativity and, therefore, encourages the development of mathematical talent.
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