A muon collider represents the ideal machine to reach very high center-of-mass energies and luminosities by colliding elementary particles. This is the result of the low level of beamstrahlung and ...synchrotron radiation compared to linear or circular electron-positron colliders. In contrast with other lepton machines, the design of a detector for a multi-TeV muon collider requires detailed knowledge of the interaction region due to the significant backgrounds created by muon beam decays in the collider ring. The physics reach can be properly evaluated only when the detector performance in such an environment is determined. In this work, the backgrounds generated by muon beams of 750 GeV are characterized and the performance of the tracking system and the calorimeter detector is illustrated. Solutions to minimize the effect of the beam-induced backgrounds are discussed and applied to obtain track and jet reconstruction performance. The μ+μ−→Hν →b ν process is fully simulated and reconstructed to demonstrate that physics measurements are possible in this harsh environment. The measurement precision for the Higgs boson coupling to b is evaluated for s=1.5, 3, and 10 TeV and compared to other proposed machines.
Over the past half-century, we have become increasingly aware of the ubiquity of DNA damage. Under the constant exposure to exogenous and endogenous genomic stress, cells must attempt to replicate ...damaged DNA. The encounter of replication forks with DNA lesions triggers several cellular responses, including the activation of translesion DNA synthesis (TLS), which largely depends upon specialized DNA polymerases with flexible active sites capable of accommodating bulky DNA lesions. A detrimental aspect of TLS is its intrinsic mutagenic nature, and thus the activity of the TLS polymerases must ideally be restricted to synthesis on damaged DNA templates. Despite their potential clinical importance in chemotherapy, TLS inhibitors have been difficult to identify since a direct assay designed to quantify genomic TLS events is still unavailable. Herein we discuss the methods that have been used to validate TLS inhibitors such as USP1, p21 and Spartan, highlighting research that has revealed their contribution to the control of DNA synthesis on damaged and undamaged templates.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
A
bstract
Two-particle azimuthal correlations have been measured in neutral current deep inelastic
ep
scattering with virtuality
Q
2
>
5 GeV
2
at a centre-of-mass energy
s
= 318 GeV recorded with the ...ZEUS detector at HERA. The correlations of charged particles have been measured in the range of laboratory pseudorapidity
−
1
.
5
< η <
2
.
0 and transverse momentum 0
.
1
< p
T
<
5
.
0 GeV and event multiplicities
N
ch
up to six times larger than the average 〈
N
ch
〉 ≈ 5. The two-particle correlations have been measured in terms of the angular observables
c
n
{2}
= 〈〈
cosn
Δ
φ
〉〉, where
n
is between 1 and 4 and ∆
φ
is the relative azimuthal angle between the two particles. Comparisons with available models of deep inelastic scattering, which are tuned to reproduce inclusive particle production, suggest that the measured two-particle correlations are dominated by contributions from multijet production. The correlations observed here do not indicate the kind of collective behaviour recently observed at the highest RHIC and LHC energies in high-multiplicity hadronic collisions.
A new measurement of inclusive-jet cross sections in the Breit frame in neutral current deep inelastic scattering using the ZEUS detector at the HERA collider is presented. The data were taken in the ...years 2004–2007 at a centre-of-mass energy of
318
GeV
and correspond to an integrated luminosity of
347
pb
-
1
. The jets were reconstructed using the
k
t
-algorithm in the Breit reference frame. They have been measured as a function of the squared momentum transfer,
Q
2
, and the transverse momentum of the jets in the Breit frame,
p
⊥
,
Breit
. The measured jet cross sections are compared to previous measurements and to perturbative QCD predictions. The measurement has been used in a next-to-next-to-leading-order QCD analysis to perform a simultaneous determination of parton distribution functions of the proton and the strong coupling, resulting in a value of
α
s
(
M
Z
2
)
=
0.1142
±
0.0017
(experimental/fit)
-
0.0007
+
0.0006
(model/parameterisation)
-
0.0004
+
0.0006
(scale)
, whose accuracy is improved compared to similar measurements. In addition, the running of the strong coupling is demonstrated using data obtained at different scales.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A
bstract
Collective behaviour of final-state hadrons, and multiparton interactions are studied in high-multiplicity
ep
scattering at a centre-of-mass energy
s
= 318 GeV with the ZEUS detector at ...HERA. Two- and four-particle azimuthal correlations, as well as multiplicity, transverse momentum, and pseudorapidity distributions for charged-particle multiplicities
N
ch
≥ 20 are measured. The dependence of two-particle correlations on the virtuality of the exchanged photon shows a clear transition from photoproduction to neutral current deep inelastic scattering. For the multiplicities studied, neither the measurements in photoproduction processes nor those in neutral current deep inelastic scattering indicate significant collective behaviour of the kind observed in high-multiplicity hadronic collisions at RHIC and the LHC. Comparisons of PYTHIA predictions with the measurements in photoproduction strongly indicate the presence of multiparton interactions from hadronic fluctuations of the exchanged photon.
In choosing the best surgical treatment (total or partial laryngectomy) for patients affected by laryngeal squamous cell carcinoma (SCC), it is still necessary to identify a link between prognostic ...factors and oncological outcomes. A retrospective analysis of clinical outcomes of 819 patients affected by laryngeal cancer who underwent OPHL type II and III between 1995 to 2014 was carried out. Focusing on recurrence and its site (local, regional or distant), our cohort has been divided in two groups: patients showing recurrence (n = 108) vs those without recurrence (n = 711). Thirteen clinical-pathological parameters have been studied by univariate and multivariate analysis to identify possible correlations between recurrence and oncological outcomes (overall survival (OS), disease free survival (DFS), disease specific survival (DSS), laryngectomy free survival (LSF), laryngectomy free freedom (FFL). In multivariate analysis, we found 4 negative prognostic factors for recurrence: site of tumour (> supraglottic), cartilage invasion (> if present), perineural invasion (> if present) and type of OPHL (> in OPHL type III). The knowledge and detection of negative prognostic factors for the risk of recurrence (pN classification, cartilage involvement, perineural invasion, and thus the type of surgical treatment adopted) could increase the already well-established potentiality of OPHLs in treating cases with a safe indication after careful discussion in the tumour board.
Pulmonary rehabilitation for chronic obstructive pulmonary disease (COPD) reduces dyspnoea and improves exercise capacity and quality of life. The improvement in exercise capacity is variable and ...unpredictable, however. Respiratory system impedance obtained by forced oscillation technique (FOT) as a measure of ventilatory impairment in COPD may relate to improvement in exercise capacity with pulmonary rehabilitation. We aimed to determine if baseline FOT parameters relate to changes in exercise capacity following pulmonary rehabilitation.
At the start of rehabilitation, 15 COPD subjects (mean(SD) 75.2(6.1) years, FEV1 z-score -2.61(0.84)) had measurements by FOT, spirometry, plethysmographic lung volumes and 6-minute walk distance (6MWD). Respiratory system resistance (Rrs) and reactance (Xrs) parameters as the mean over all breaths (R
, X
), during inspiration only (R
, X
), and expiratory flow limitation (DeltaXrs = X
-X
), were calculated. FOT and 6MWD measurements were repeated at completion of rehabilitation and 3 months after completion.
At baseline, Xrs measures were unrelated to 6MWD. X
improved significantly with rehabilitation (from mean(SD) -2.35(1.02) to -2.04(0.85) cmH
O.s.L
, p=0.008), while other FOT parameters did not. No FOT parameters related to the change in 6MWD at program completion. Baseline X
DeltaXrs, and FVC z-score correlated with the change in 6MWD between completion and 3 months after completion of rehabilitation (r
=0.62, p=0.03; r
=-0.65, p=0.02; and r
=0.62, p=0.03, respectively); with worse ventilatory impairment predicting loss of 6MWD. There were no relationships between Rrs parameters, FEV1 or FEV1/FVC z-scores and changes in 6MWD.
Baseline reactance parameters may be helpful in predicting those patients with COPD at most risk of loss of exercise capacity following completion of pulmonary rehabilitation.
A
bstract
Charm production in charged current deep inelastic scattering has been measured for the first time in
e
±
p
collisions, using data collected with the ZEUS detector at HERA, corresponding to ...an integrated luminosity of 358 pb
−1
. Results are presented separately for
e
+
p
and
e
−
p
scattering at a centre-of-mass energy of
s
= 318 GeV within a kinematic phase-space region of 200 GeV
2
<
Q
2
< 60000 GeV
2
and
y
< 0.9, where
Q
2
is the squared four-momentum transfer and
y
is the inelasticity. The measured cross sections of electroweak charm production are consistent with expectations from the Standard Model within the large statistical uncertainties.
An event topology with two secondary vertices compatible with the decay of short-lived particles was found in the analysis of neutrino interactions in the OPERA target. The observed topology is ...compatible with tau neutrino charged current (CC) interactions with charm production and neutrino neutral current (NC) interactions with Formula omitted pair production. However, other processes can mimic this topology. A dedicated analysis was implemented to identify the underlying process. A Monte Carlo simulation was developed and complementary procedures were introduced in the kinematic reconstruction. A multivariate analysis technique was used to achieve an optimal separation of signal from background. Most likely, this event is a Formula omitted CC interaction with charm production, the tau and charm particle decaying into 1 prong and 2 prongs, respectively. The significance of this observation is evaluated.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The muon collider represents one of the most promising solutions for a future machine exploring the high energy frontier, but several challenges due to the 2.2 μsec muon lifetime at rest have to be ...carefully considered. The LEMMA project is investigating the possibility of producing low emittance muon/antimuon pairs from the e+e− annihilation process at threshold energy, resulting in small transverse emittance beams without any additional beam cooling. However most of the measurements available are performed at higher s values. It is therefore necessary to measure muons production in positron annihilation at threshold energy and compare the experimental results with the predictions in this specific energy regime. Apart from being a topic of physical interest by itself, these near to threshold measurements can have a sizeable impact on the estimation of the ultimate luminosity achievable in a muon collider with the LEMMA injection scheme.
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