In nonmyeloablative allogeneic hematopoietic stem cell transplantation (HSCT), high-dose cytotoxic therapy as the conceptual basis for treating hematopoietic malignancies has been replaced by ...graft-versus-tumor effects. The use of potent pre- and postgrafting immunosuppression derived from preclinical studies has allowed omission of myeloablative cytotoxic therapy without compromising hematopoietic donor cell engraftment. This results in a marked reduction in transplant-related toxicities that makes older or medically infirm patients candidates for this treatment option. This patient group is more representative of the population with cancer and would have been ineligible for conventional HSCT. Initial results in patients with a variety of hematologic malignancies have been encouraging with documented sustained cytogenetic and molecular remissions in a substantial number of sometimes heavily pretreated and previously refractory patients. Even though patients with hematologic malignancies will likely require conversion to full donor hematopoiesis for long-term disease control, a state of mixed hematopoietic chimerism might suffice to "cure" the disease phenotypes in various nonmalignant diseases. Strategies aimed at optimizing peritransplant immunosuppression may eventually eliminate the need for pretransplant total body irradiation, which is relevant for minimizing late toxicities. Enhancing graft-versus-tumor effects by virtue of postgrafting vaccination of recipients against tumor-specific antigens may help to use this transplant approach more effectively in the treatment of solid tumors.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
There is agreement on the need for change in engineering education, but lacking are the motivation, knowledge, or skills to effect change. With that in mind, we held a workshop in June 2009 that ...sought to engage faculty members who are change leaders. Over the two-day workshop, we solicited their views on departmental and institutional challenges, the knowledge, skills and abilities (KSAs) necessary for implementing academic change, and best practices for motivating engineering faculty to seek opportunities to acquire the necessary KSAs. We expected participants to identify and mentor change leaders on their home campuses. Following the workshop, we translated the participants' views on the structure and content of programs they felt will be most successful into a program in academic change leadership. This paper describes how we distilled tacit and explicit knowledge from change leaders and leveraged that distillation to advance on-campus change as well as initiate the preparation of expanded cadres of change leaders. The information presented stemmed from discussions with engineering faculty who have implemented change on their campuses and includes lessons from their experiences and perceptions of the challenges they face.
Examines multicultural education, including issues such as diversity and social identity in the US educational system; 11 articles. Contents: 50 years after Brown v. Board of Education: the promise ...and challenge of multicultural education, by Sabrina Zirkel, Nancy Cantor; The benefits of diversity in education for democratic citizenship, by Patricia Gurin, Biren (Ratnesh) A. Nagda, Gretchen E. Lopez; Developing a more inclusive social identity: an elementary school intervention, by Melissa A. Houlette, Samuel L. Gaertner, Kelly M. Johnson, Brenda S. Banker, Blake M. Riek, John F. Dovidio; What will you think of me? racial integration, peer relationships and achievement among White students and students of color, by Sabrina Zirkel; Interethnic contact, curriculum, and attitudes in the first year of college, by Gretchen E. Lopez; Is there an inherent mismatch between how Black and White students expect to succeed in college and what their colleges expect from them?, by Aaron M. Brower, Annemarie Ketterhagen; Family life and school experience: factors in the racial identity development of Black youth in White communities, by Beverly Daniel Tatum; Shift happens: Spanish and English transmission between parents and their children, by Aída Hurtado, Luis A. Vega; Students' of color and European American students' stigma-relevant perceptions of university instructors, by Lisa M. Brown, Heather Dobbins; Color-line as fault-line: teaching interethnic relations in California in the 21st century, by Stanley O. Gaines, Jr.; Learning about difference, learning with others, learning to transgress, by Biren (Ratnesh) A. Nagda, Chan-woo Kim, Yaffa Truelove.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
For the first time ever in the U.S., a centralized registry will make it possible to identify which preschool children are in need of immunizations. Presently, records of immunizations are dispersed ...in patients’ charts among multiple providers, thus making tracking the immunization status of children difficult. Automating current immunization records and patient tickler systems likely will increase efficiency and productivity of office staff and contribute to increasing preschool immunization rates. We examine the process used in San Diego, California, to create the support and infrastructure for a countywide immunization system. Steps include establishing physician, community, and technical advisory groups, and parental focus groups; a comprehensive assessment of existing computer systems and required design elements; and marketing the system to providers and health care institutions.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SBCE, SBJE, UL, UM, UPCLJ, UPUK
