Two devices intended for copper cylindrical liner gasdynamic acceleration to velocities of 5–7 km/s using the chemicals explosion energy have been investigated. It has been demonstrated that the ...acceleration of quasi-isentropically and isentropically loaded liners under the conditions of high-level dynamics, symmetry of deposition, and suppression of shock-induced dusting is feasible.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
12.
Status of laser polarimeter at VEPP-4M Blinov, V.E.; Bedareva, T.V.; Zakharov, S.A. ...
Journal of instrumentation,
08/2020, Volume:
15, Issue:
8
Journal Article
Peer reviewed
Laser polarimeter facility at VEPP-4M accelerator is designed to calibrate the beam energy by resonance depolarization method in the energy region of the Υ-meson. The laser trigger and laser ...polarization control system has been upgraded. A new water-cooled vacuum mirror is being developed.
The ejection of particles from the free surface of metal liners accelerated to velocities of 4–5 km/s using explosive energy has been investigated. It is shown experimentally that the effect of ...shock-wave dusting can be suppressed by quasi-isentropic or isentropic loading of liners during their acceleration.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Hundreds of millions of people worldwide are infected by various species of parasitic flatworms. Without
treatment, acute and chronical infections frequently lead to the development of severe ...pathologies and even death.
Emerging data on a decreasing efficiency of some important anthelmintic compounds and the emergence of resistance to them force the search for alternative drugs. Parasitic flatworms have complex life cycles, are laborious and
expensive in culturing, and have a range of anatomic and physiological adaptations that complicate the application
of standard molecular-biological methods. On the other hand, free-living flatworm species, evolutionarily close to
parasitic flatworms, do not have the abovementioned difficulties, which makes them potential alternative models
to search for and study homologous genes. In this review, we describe the use of the basal free-living flatworm
Macrostomum lignano as such a model. M. lignano has a number of convenient biological and experimental properties, such as fast reproduction, easy and non-expensive laboratory culturing, optical body transparency, obligatory
sexual reproduction, annotated genome and transcriptome assemblies, and the availability of modern molecular
methods, including transgenesis, gene knockdown by RNA interference, and in situ hybridization. All this makes
M. lignano amenable to the most modern approaches of forward and reverse genetics, such as transposon insertional mutagenesis and methods of targeted genome editing by the CRISPR/Cas9 system. Due to the availability of
an increasing number of genome and transcriptome assemblies of different parasitic flatworm species, new knowledge generated by studying M. lignano can be easily translated to parasitic flatworms with the help of modern
bioinformatic methods of comparative genomics and transcriptomics. In support of this, we provide the results of
our bioinformatics search and analysis of genes homologous between M. lignano and parasitic flatworms, which
predicts a list of promising gene targets for subsequent research.
The beam energy measurement system (BEMS) for the upgraded Beijing electron–positron collider BEPC-II is described. The system is based on measuring the energies of Compton back-scattered photons. ...The relative systematic uncertainty of the electron and positron beam energy determination is estimated as 2×10−5. The relative uncertainty of the beam's energy spread is about 6%.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The structure and the mechanical properties of low-carbon low-alloy 10Kh3A steel with an overequilibrium nitrogen content (0.20 wt %) are studied after heat treatment under various conditions. The ...quenching (950°C) and tempering (400°C) temperatures that result in significant hardening of the steel (σ
u
= 1680 MPa, σ
0.2
= 1550 MPa) at the retained plasticity (δ = 11%, ψ = 44%) that is high enough for practical application are determined. The strength of the 10Kh3A steel is higher than that of low-alloy nitrogen-free low-carbon 18Kh2N4VA steel, which is alloyed with nickel and tungsten and is widely used for heavily loaded structural members.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The rare mineral zavaritskite has been identified in sulfide–magnetite ore of the Aktash skarn deposit, northern Tajikistan, and has been studied by optical and scanning electron microscopy, and ...backscattered electron diffraction. Zavaritskite is associated with native bismuth, chalcopyrite, galena, supergene bismuth oxides, and anglesite. It is the first occurrence of zavaritskite not only at the Aktash deposit, but for all of the Kurama bismuth subzone of the Chatkal–Kurama metallogenic zone.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Aim: to perform a comparative analysis of the clinical efficacy of 2.5% phenylephrine with and without hypromellose for the treatment of extra accommodation strain in schoolchildren with myopia and ...to perform an experimental evaluation of the pharmacological effective of active ingredient of the finished dosage form (FDF) of preparations containing 2.5% phenylephrine with and without excipients. Patients and Methods: this clinical study enrolled 122 schoolchildren, 11–17 years old, with extra accommodation strain of various severity. The children were split into two groups. The group 1 patients received Irifrin® BK, containing 2.5% phenylephrine with hypromellose, one eye drop at the bedtime during 30 days, and the group 2 patients — Preparation A (2.5% phenylephrine without hypromellose) according to the same dosage regimen. The accommodative function was evaluated using the Speedy-i accommodation analyzer, and the coefficients of accommodation response before and 30 days after the treatment were determined. The experimental study was carried out in 40 sexually mature male rabbits of the Soviet Chinchilla breed to evaluate the development and duration of mydriatic effect and to measure the concentration of active ingredient — phenylephrine with hypromellose, as an excipient (Irifrin® and Irifrin® BK), phenylephrine without hypromellose (Preparation A) and phenylephrine with sodium hyaluronate as an excipient (Preparation B) in the aqueous humor within the eye anterior chamber using high-performance gas-liquid chromatography with tandem mass spectrometric detection. Results: the drug therapy of extra accommodation strain comprising 2.5% phenylephrine hydrochloride solution with hypromellose as an excipient (Irifrin® BK) demonstrated a decrease in severity of extra accommodation strain after 30 days of treatment. At the same time, Preparation B did not demonstrate its efficacy. In the experimental study, Irifrin® and Irifrin® BK were superior to Preparations A and B (without hypromellose as an excipient) as regards the peak mydriatic effect and the time required to reach maximal mydriasis. The peak phenylephrine concentrations in the aqueous humor within the eye anterior chamber were reached five minutes after instilling 1 drop of 2.5% phenylephrine with hypromellose solutions. These peaks were significantly higher than those observed after instilling Preparations A and B — phenylephrine in the same concentration but without hypromellose. Conclusion: the addition of hypromellose as an excipient to FDF of 2.5% phenylephrine solution helps to optimize pharmacodynamics and pharmacokinetics of the active ingredient by accelerating its inflow in the aqueous humor within the eye anterior chamber, increasing the topical bioavailability, and extending the exposure interval. It is likely that the above factors have underpinned the efficacy of Irifrin® and Irifrin® BK drugs used for the treatment of extra accommodation strain. The same results were obtained in this study comparing the clinical efficacy of 2.5% phenylephrine solution with hypromellose and its preparations without hypromellose used for the treatment of schoolchildren with extra accommodation strain amid myopia, as proven by the significant improvement of the accommodation indices during the treatment. Keywords: extra accommodation strain, mydriatic effect, peak concentration, rabbit, myopia, phenylephrine, hypromellose. For citation: Makhova M.V., Shikh E.V., Strakhov V.V. et al. Clinical and experimental rationale for using phenylephrine with hypromellose for the treatment of extra accommodation strain in patients with myopia. Russian Journal of Clinical Ophthalmology. 2023;23(1):33–38 (in Russ.). DOI: 10.32364/2311-7729-2023-23-1-33-38
The schematic diagram of a two-stage hybrid piston power machine with liquid piston in the second stage, which maintains gas compression up to pressures of 10 MPa, is presented. On the basis of the ...equations of conservation of flow and energy, a method for he calculation of compression and discharge processes is developed. Analytical expressions are obtained for determining the flow rates of the liquid in the second stageand in the gas cap as well as the fluid pressures at characteristic points of the system. Certification of the new technique is performed and the working processes that take place in the hydraulic part of a two-stage hybrid piston power machine are analyzed.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
20.
Development of a picosecond MCP based particle detector Barnyakov, A.Yu; Barnyakov, M.Yu; Blinov, V.E. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2020, Volume:
952
Journal Article
Peer reviewed
A time-of-flight detector based on microchannel plates (MCP) is under development. The main goal is the creation of a radiation hard large area detector providing ∼10 ps time resolution for single ...charged particle in strong magnetic field. Conceptually, the detector consists of Cherenkov radiator covered with semitransparent photocathode followed by a chevron pair of MCPs. The detector design and the status of the development are reported.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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