Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP ...levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis.
Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control‐treatment CT group and 48 assigned to intensive‐treatment IT group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention.
Results: Periodontal conditions were significantly improved (P <0.05) 6 months after intensive periodontal treatment. In parallel, the primary outcomes including systolic and diastolic BP and EMPs were markedly reduced in the IT group compared with the CT group (absolute difference: 12.57 and 9.65 mm Hg and 581.59/μL, respectively; 95% confidence intervals: 10.45 to 14.69, 7.06 to 12.24, and 348.12 to 815.06, respectively; P <0.05). Reduction in BP levels and EMPs was related to improvement in probing depth (r = 0.358, 0.363, and 0.676, respectively, by the Pearson product‐moment correlation; P = 0.009, 0.008, and P <0.001, respectively).
Conclusion: To the best knowledge of the authors, the present study demonstrates for the first time that intensive periodontal intervention without any antihypertensive medication therapy may be an effective means to lower levels of BP and EMPs in patients with prehypertension with periodontitis.
Full text
Available for:
BFBNIB, CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Background
The free peroneal artery perforator (FPAP) flap is used for soft tissue defects after burns and trauma. However, the use of FPAP flaps to repair limb soft tissue defects for immediate ...reconstruction was rarely reported previously. Therefore, the purpose of this report is to evaluate free peroneal artery perforator flap to reconstruct traumatic limb soft tissue defects for immediate reconstruction.
Patients and Methods
A total of 25 cases of limb soft tissue defects undergoing immediate reconstruction of FPAP flap transfer were retrospectively evaluated from January 2019 to June 2019 in our institute. The locations of defects included the palm (10 cases), finger (5 cases), foot (7 cases), ankle (2 cases) and wrist (1 case). The sizes of defect varied from 3 × 2 cm to 15 × 7 cm (54.1 cm2 in average). Flaps were harvested based on the peroneal perforator vessels, initially marked using hand‐held Doppler.
Results
Average size of harvested flap was 9.7 × 6.2 cm (ranging from 3.5 × 2 cm to 16 × 8 cm). All perforators were harvested from the peroneal artery and the arterial diameter ranged from 0.8 to 1.7 mm. The average pedicle length was 3.04 cm (range, 1.85–4.75 cm). Five vascular thrombosis were found including three cases of arterial thrombosis and two cases of venous thrombosis which were successfully salvaged by re‐operation and vein graft. Satisfying functional outcome and acceptable appearance were achieved at 6 months or longer after surgery (range, 6–15 months, 12 months in average). All flaps survived at the end‐point.
Conclusions
The FPAP flap is a reliable and thin fasciocutaneous flap, which can be used for repairing limb soft tissue defects. The FPAP flap can be used for covering defects with various appearances, locations, and sizes.
Full text
Available for:
FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
New anhydrous lanthanide metal–organic frameworks (MOFs) Pr(tip)1.52n (tip‐Pr), Nd(tip)1.52n (tip‐Nd), Eu(tip)1.52n (tip‐Eu), and Eu(OH)(mip)n (mip‐Eu) (tip=5‐tert‐butylisophthalate anion, ...mip=5‐methylisophthalate ion), have been hydrothermally synthesized and structurally characterized by elemental analyses, FT‐IR spectroscopy, single‐crystal X‐ray diffraction, thermal gravimetric analysis/differential thermal analysis (TG/DTA), and X‐ray powder diffraction (XRPD) techniques. MOFs tip‐Pr, tip‐Nd, and tip‐Eu are isostructural anhydrous compounds, and exhibit an unprecedented 3D microporous structure with hexagonal channel arrays. The selectively prepared MOF mip‐Eu presents an interpenetrated 3D microporous architecture containing the hydroxyl cluster chains. Solid‐state photoluminescence properties at room temperature indicate that both tip‐Eu and mip‐Eu display the characteristic of the Eu3+ ion spectrum dominated by the 5D0→7FJ (J=0‐4) transition. Compared with mip‐Eu, tip‐Eu displays the very high solid‐state quantum yield (0.62±0.03) and longer lifetime value (0.94±0.01 ms), which is due to the absence of the hydroxyl groups from the solid‐state structure of tip‐Eu. More importantly, a new method to directly investigate the potential of solid‐state lanthanide MOFs for ionic sensing in aqueous solutions has been developed, and successfully applied it to study the potential sensing function of tip‐Eu for polyoxometalates (POMs). The possible mechanism for the quenching effect of POMs on the fluorescence of tip‐Eu is elucidated by the strongly competitive absorption of the excited light source energy between POMs and tip ligands. The very promise for the highly sensitive sensing for polyoxometalates, together with the characteristic of the reversible fluorescence response, suggest that solid‐state tip‐Eu can be an excellent candidate for the directly photoluminescent detection of POMs in aqueous solutions.
Tip for detection: New anhydrous 3D microporous lanthanide metal–organic frameworks (MOFs) with hexagonal channel arrays were synthesized based on the 5‐tert‐butylisophthalate ligand (tip; see figure). The potential sensing function of the Eu‐based MOF for polyoxometalates (POMs) in an aqueous solution is investigated for the first time.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
In attempts to investigate the potential luminescent sensing materials for sensitive detection of environmental pollutants, a new family of lanthanide wheel cluster organic frameworks (Ln-WCOFs) ...UJN-Ln4 has been constructed by employing one of the cycloalkane dicarboxylic acid derivatives. Adopting different conformations, the ligand links Ln4 second building units (SBUs) and Ln24 tertiary building units (TBUs) to form a unique wheel cluster layer-pillared 3D framework featuring the coexistence of hydrophobic nanosized channels and trigonal antiprism arrays with hydrophilic cagelike chambers. Apart from charming structures, isostructural UJN-Ln4 displays interesting porous, water-stable features. Systematic luminescence studies demonstrate that solvent water molecules can enhance the emission intensity of solid-state UJN-Eu4. Acting as a recyclable luminescent probe, water-stable luminescent UJN-Eu4 exhibits superior “turn-off” detection for Fe3+ and Cu2+ ions in aqueous solutions. Due to the nanosized hydrophobic channels, UJN-Eu4 also shows highly sensitive sensing of sodium dodecyl benzenesulfonate (SDBS) via luminescence “turn-on” respondence, representing the first example of quantitatively detecting SDBS in aqueous solutions by employing luminescent lanthanide frameworks as fluorescent sensors. The results also open up the exploration of novel luminescent Ln-WCOFs exhibiting unique applications in sensitive detecting of harmful pollutants in aquatic environments.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM
Laborious and costly detection of miRNAs has brought challenges to its practical applications, especially for home health care, rigorous military medicine, and the third world. In this work, we ...present a pH-responsive miRNA amplification method, which allows the detection of miRNA just using a pH test paper. The operation is easy and no other costly instrument is involved, making the method very friendly. In our strategy, a highly efficient isothermal amplification of miRNA is achieved using an improved netlike rolling circle amplification (NRCA) technique. Large amounts of H+ can be produced as a byproduct during the amplification to induce significant changes of pH, which can be monitored directly using a pH test paper or pH-sensitive indicators. The degree of color changes depends on the amount of miRNA, making it possible for quantitative analysis. As an example, the method is successfully applied to quantify a miRNA (miR-21) in cancer cells. The results agree well with that from the prevalent qRT-PCR analysis. It is the first time that a paper-based point-of-care testing (POCT) is developed for the detection of miRNAs, which might promote the popularization of miRNAs working as biomarkers for diagnostic purposes.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM
Abstract 3D geological modeling technology has achieved visualization of underground reservoirs in oil and gas fields, and has been widely applied in oil and gas field development. 3D geological ...modeling includes structural modeling and attribute modeling, and strata and faults can be completed based on data from oil and gas field exploration and development. The porosity and permeability in the geological attribute model can be established based on logging interpretation conclusions and other relevant data, The establishment of a saturation model has always been a difficulty in 3D geological modelling. As the water saturation, is different from porosity and permeability of an oil field. Saturation is distributed under the control of factors such as gravity and capillary force, and cannot be established through spatial simulation interpolation. Instead, the influence of factors such as gravity and capillary force should be considered. This article takes the shallow sandstone M oilfield in Kazakhstan as an example, and establishes the J function of the oilfield by combining the capillary pressure experiment of the core well, in order to establish an oilfield saturation model.
The structural, elastic and thermodynamic properties of FeB, Fe2B, orthorhombic and tetrahedral Fe3B, FeB2 and FeB4 iron borides are investigated by first-principle calculations. The elastic ...constants and polycrystalline elastic moduli of Fe–B compounds are usually large especially for FeB2 and FeB4, whose maximum elastic constant exceeds 700 GPa. All of the six compounds are mechanically stable. The Vickers hardness of FeB2 is estimated to be 31.4 GPa. Fe2B and FeB2 are almost isotropic, while the other four compounds have certain degree of anisotropy. Thermodynamic properties of Fe–B compounds can be accurately predicted through quasi-harmonic approximation by taking the vibrational and electronic contributions into account. Orthorhombic Fe3B is more stable than tetrahedral one and the phase transition pressure is estimated to be 8.3 GPa.
•The equilibrium cohesive properties of Fe–B system are obtained.•The elastic constants and polycrystalline elastic moduli are usually large.•The Vickers hardness of FeB2 is estimated to be 31.4 GPa.•Thermodynamic properties of Fe–B compounds are predicted.•Orthorhombic Fe3B is more stable than tetrahedral one.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Multiple-thermal-fluid (MTF) stimulation technology has been successfully applied in heavy-oil reservoir development, resulting in the significant enhancement of oil production. However, the ...underlying mechanism of multi-component coupling remains unclear. This paper constructs a coupling model for MTF stimulation, investigates the coupling mechanism of different media in various zones during multiple-cycle stimulation operations, and compares the implementation effect with field results. The findings reveal that (1) based on media distribution, the area from near-wellbore to far well locations can be divided into four zones: high-temperature oil-viscosity-reduction zones, compound action zones, energy-replenishment zones, and unaffected zones. (2) In the high-temperature oil-viscosity-reduction zone, the latent heat of vaporization is released by steam, and ultra-heavy oil absorbs heat and reduces its viscosity, which plays a dominant role in the production of MTF. In the compound action zone, hot water, CO2, and N2 exhibit a synergistic effect which enhances overall performance. In the energy-replenishment zone, a small amount of N2 provides pressure maintenance and an additional energy supply. (3) As more cycles of stimulation are conducted, the compound action zone expands, while the energy-replenishment zone contracts. Simultaneously, there is a decrease in contribution rate from the high-temperature viscosity-reduction zone to oil production but an increase from both the compound action zone and energy-replenishment zone up to 30%. Based on the dynamic law of representative wells, this paper proposes a multi-media zonal coupling mechanism, providing a reference for subsequent research on MTF stimulation mechanisms and the adjustment of production measures.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
HERD is the High Energy cosmic-Radiation Detection instrument proposed to operate onboard China’s space station in the 2020s. It is designed to detect energetic cosmic ray nuclei, leptons and photons ...with a high energy resolution ( ∼1% for electrons and photons and 20% for nuclei) and a large geometry factor (>3 m2 sr for electrons and diffuse photons and > 2m2 sr for nuclei). In this work we discuss the capability of HERD to detect monochromatic γ-ray lines, based on simulations of the detector performance. It is shown that HERD will be one of the most sensitive instruments for monochromatic γ-ray searches at energies between ∼ 10 to a few hundred GeV. Above hundreds of GeV, Cherenkov telescopes will be more sensitive due to their large effective area. As a specific example, we show that a good portion of the parameter space of a supersymmetric dark matter model can be probed with HERD.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
PDF
