Uterine Clear Cell Carcinoma Rauh‐Hain, J. Alejandro; Olawaiye, Alexander B; Boruta, David M
Uncommon Gynecologic Cancers,
11/2014
Book Chapter
Uterine clear cell carcinoma (UCCC) is an uncommon variant of carcinoma of the uterus that represents no more than 5% of all endometrial carcinomas. The etiology of UCCC is not well understood but ...appears to be unique from endometrioid histology, and the suggestion by some recent studies that clear cell endometrial cancer may have a premalignant lesion deserves more studies. Comprehensive surgical staging is critical in order to plan appropriate postoperative management. Patients with UCCC often experience relapse in the pelvis, in para‐aortic nodes, and at distant sites, whereas they do not seem to have a high propensity to fail in the abdomen. Pelvic radiotherapy might reduce the risk of pelvic recurrence. In stage III or IV UCCC and in women with recurrent disease, adjuvant chemotherapy with platinum‐based chemotherapy, paclitaxel, and doxorubicin either in a doublet or triplet combination has demonstrated efficacy. The triplet combination is more toxic.
Bimetallic paddlewheel complexes derived from imides of (
S
)-
tert
-leucine adopt 'chiral crown' configurations in which the four imide groups are projected in a chiral arrangement on one face, and ...the four
tert
-butyl groups are projected on the opposite face. In this contribution, the generality of the chiral crown conformation is examined through crystallographic studies where the metal and the nature of the chiral ligands are altered. Based upon these observations, a model is proposed to explain the factors which create bias for the chiral crown configuration.
The generality of the chiral crown conformation is examined by varying the metal and the chiral ligands in crystalline complexes. Factors that bias for the chiral crown conformation are explained.
The majority of women diagnosed with epithelial ovarian cancer will have persistent or recurrent disease after initial treatment. We evaluated response and toxicity in women with advanced stage ...disease given salvage paclitaxel as a low-dose, weekly infusion. We performed a retrospective review of 22 women with advanced stage epithelial ovarian (19 women) or primary peritoneal carcinoma (3 women) who had received low-dose, weekly paclitaxel salvage therapy. All women had refractory, persistent, or recurrent disease following first-line treatment with paclitaxel and platin chemotherapy. Response and toxicity were assessed. Measurable disease present on physical or radiologic exam and serum carbohydrate antigen-125 levels were used to assess disease response. Overall response rate to low-dose, weekly paclitaxel salvage therapy was 50% (27% complete, 23% partial). Median progression-free interval (PFI) in responders was 27 weeks (range, 14-68 weeks). Stabilization of disease occurred in an additional 27% of patients with a median PFI of 22 weeks (range, 15-89 weeks). No difference in response was detected between the 7 women with platin-sensitive disease and the 15 women with platin-resistant disease(P=0.19). The median dose of paclitaxel was 80 mg/m
2
(range, 60-80 mg/m
2
). During a total of 325 weeks of paclitaxel treatment (median per patient, 12 weeks; range, 6-49 weeks), 13 treatment delays occurred (hematologic indication, 9; nonhematologic indication, 4). No cases of grade 4 hematologic toxicity, sepsis, or worsening neuropathy were documented. Weekly paclitaxel infusion given as salvage therapy results in significant clinical response, even in women previously treated with paclitaxel. The regimen is well tolerated with no cases of grade 4 neutropenia or worsening neuropathy in our population.
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DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
We retrospectively evaluated the effectiveness of ultrasonography as a diagnostic tool for investigating pathology in the posterior tibial tendon by comparing the preoperative ultrasonograms for 17 ...patients with their recorded surgical findings. In all cases, the surgical findings confirmed the ultrasonographic diagnoses: 3 inflammations, 4 partial tears, and 10 ruptures. Interestingly, two ruptures had been undiagnosed by magnetic resonance imaging. Ultrasonography, which seems to be a reliable means of visualizing the extent of pathology of the symptomatic posterior tibial tendon, may be a valuable tool in surgical planning.
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