Proton exchange membranes with short-pathway through-plane orientated proton conductivity are highly desirable for use in proton exchange membrane fuel cells. Magnetic field is utilized to create ...oriented structure in proton exchange membranes. Previously, this has only been carried out by proton nonconductive metal oxide-based fillers. Here, under a strong magnetic field, a proton-conducting paramagnetic complex based on ferrocyanide-coordinated polymer and phosphotungstic acid is used to prepare composite membranes with highly conductive through-plane-aligned proton channels. Gratifyingly, this strategy simultaneously overcomes the high water-solubility of phosphotungstic acid in composite membranes, thereby preventing its leaching and the subsequent loss of membrane conductivity. The ferrocyanide groups in the coordinated polymer, via redox cycle, can continuously consume free radicals, thus helping to improve the long-term in situ membrane durability. The composite membranes exhibit outstanding proton conductivity, fuel cell performance and durability, compared with other types of hydrocarbon membranes and industry standard Nafion
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With the rapid growth and development of proton-exchange membrane fuel cell (PEMFC) technology, there has been increasing demand for clean and sustainable global energy applications. Of the many ...device-level and infrastructure challenges that need to be overcome before wide commercialization can be realized, one of the most critical ones is increasing the PEMFC power density, and ambitious goals have been proposed globally. For example, the short- and long-term power density goals of Japan's New Energy and Industrial Technology Development Organization are 6 kilowatts per litre by 2030 and 9 kilowatts per litre by 2040, respectively. To this end, here we propose technical development directions for next-generation high-power-density PEMFCs. We present the latest ideas for improvements in the membrane electrode assembly and its components with regard to water and thermal management and materials. These concepts are expected to be implemented in next-generation PEMFCs to achieve high power density.
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GEOZS, IJS, IMTLJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK, ZAGLJ
Between 1944 and 1953, a power struggle emerged between New York governor Thomas Dewey and U.S. senator Robert Taft of Ohio that threatened to split the Republican Party. Bowen reveals how this ...two-man battle for control of the GOP--and the Republican presidential nomination--escalated into a divide of ideology that ultimately determined the party's political identity.
Liquid metal elastomer (LME)—that is, liquid metal particles dispersed in elastomer—is a soft material that has useful electric, dielectric, and thermal properties. Two issues with LME are sought to ...be addressed: 1) the dense liquid metal (LM) particles can settle before curing of the elastomer, and 2) the LM particles are separated by a thin layer of insulating elastomer and therefore require some “mechanical sintering” to break this layer to create conductive paths. These issues are addressed using an LME containing elastic particles (LMEP). Elastic polydimethylsiloxane particles (PPs) and LM particles jam to prevent particle settling. Meanwhile, the PPs reduce the loading necessary to create conductive paths, thus decreasing the density and cost relative to LME. Surprisingly, the particles percolate into conductive paths prior to curing the LMEP but not in LME. The dielectric constant, electrical conductivity, and thermal conductivity of LMEPs are investigated by changing the volume fraction of LM particles, polydimethylsiloxane pre‐polymer and PPs, and propose an LMEP with the optimal ratio. In addition, LMEP‐based sensors and circuits are demonstrated for wearable electronics.
Liquid metal elastomer (LME) has useful electric, dielectric, and thermal properties. While, the dense liquid metal (LM) particles can settle before curing the elastomer decreases the above properties. This problem is addressed by using an LME containing elastic particles (LMEP). Elastic polydimethylsiloxane particles and LM particles jam to prevent particle settling. The dielectric constant, electrical conductivity, and thermal conductivity of LMEPs are investigated by changing the volume fraction. In addition, LMEP‐based sensors and circuits are demonstrated for wearable electronics.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Abstract
Ion-scale wave events or
wave storms
in the solar wind are characterized by enhancements in magnetic field fluctuations as well as coherent magnetic field polarization signatures at or ...around the local ion cyclotron frequencies. In this paper, we study in detail one such wave event from Parker Solar Probe's (PSP) fourth encounter, consisting of an initial period of left-handed (LH) polarization abruptly transitioning to a strong period of right-handed (RH) polarization, accompanied by a clear core beam structure in both the alpha and proton velocity distribution functions. A linear stability analysis shows that the LH-polarized waves are anti-sunward propagating Alfvén/ion cyclotron waves primarily driven by a proton cyclotron instability in the proton core population, and the RH polarized waves are anti-sunward propagating fast magnetosonic/whistler waves driven by a firehose-like instability in the secondary alpha beam population. The abrupt transition from LH to RH is caused by a drop in the proton core temperature anisotropy. We find very good agreement between the frequencies and polarizations of the unstable wave modes as predicted by linear theory and those observed in the magnetic field spectra. Given the ubiquity of ion-scale wave signatures observed by PSP, this work gives insight into which exact instabilities may be active and mediating energy transfer in wave–particle interactions in the inner heliosphere, as well as highlighting the role a secondary alpha population may play as a rarely considered source of free energy available for producing wave activity.
Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T ...effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice. A short course of rapamycin treatment boosted the immunomodulatory efficacy of SA-FasL microgels, resulting in acceptance and function of allografts over 200 days. Survivors generated normal systemic responses to donor antigens, implying immune privilege of the graft, and had increased CD4+CD25+FoxP3+ T regulatory cells in the graft and draining lymph nodes. Deletion of T regulatory cells resulted in acute rejection of established islet allografts. This localized immunomodulatory biomaterial-enabled approach may provide an alternative to chronic immunosuppression for clinical islet transplantation.
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IJS, KISLJ, NUK, SBMB, UL, UM, UPUK
Since 2013, group A rotavirus strains characterized as novel DS-1-like intergenogroup reassortant "equine-like G3" strains have emerged and spread across 5 continents among human populations in at ...least 14 countries. Here, we report a novel one-step TaqMan quantitative real-time reverse transcription-PCR assay developed to genotype and quantify the viral load for samples containing rotavirus equine-like G3 strains. Using a universal G forward primer and a newly designed reverse primer and TaqMan probe, we developed and validated an assay with a linear dynamic range of 227 to 2.3 × 10
copies per reaction and a limit of detection of 227 copies. The percent positive agreement, percent negative agreement, and precision of our assay were 100.00%, 99.63%, and 100.00%, respectively. This assay can simultaneously detect and quantify the viral load for samples containing DS-1-like intergenogroup reassortant equine-like G3 strains with high sensitivity and specificity, faster turnaround time, and decreased cost. It will be valuable for high-throughput screening of stool samples collected to monitor equine-like G3 strain prevalence and circulation among human populations throughout the world.
The dissipation of magnetized turbulence is an important paradigm for describing heating and energy transfer in astrophysical environments such as the solar corona and wind; however, the specific ...collisionless processes behind dissipation and heating remain relatively unconstrained by measurements. Remote sensing observations have suggested the presence of strong temperature anisotropy in the solar corona consistent with cyclotron resonant heating. In the solar wind, in situ magnetic field measurements reveal the presence of cyclotron waves, while measured ion velocity distribution functions have hinted at the active presence of cyclotron resonance. Here, we present Parker Solar Probe observations that connect the presence of ion-cyclotron waves directly to signatures of resonant damping in observed proton-velocity distributions using the framework of quasilinear theory. We show that the quasilinear evolution of the observed distribution functions should absorb the observed cyclotron wave population with a heating rate of 10^{-14} W/m^{3}, indicating significant heating of the solar wind.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
Cholestatic liver diseases result from impaired bile flow and are characterized by inflammation, atypical ductular proliferation, and fibrosis. The Wnt/β‐catenin pathway plays a role in bile duct ...development, yet its role in cholestatic injury remains indeterminate. Liver‐specific β‐catenin knockout mice and wild‐type littermates were subjected to cholestatic injury through bile duct ligation or short‐term exposure to 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine diet. Intriguingly, knockout mice exhibit a dramatic protection from liver injury, fibrosis, and atypical ductular proliferation, which coincides with significantly decreased total hepatic bile acids (BAs). This led to the discovery of a role for β‐catenin in regulating BA synthesis and transport through regulation of farnesoid X receptor (FXR) activation. We show that β‐catenin functions as both an inhibitor of nuclear translocation and a nuclear corepressor through formation of a physical complex with FXR. Loss of β‐catenin expedited FXR nuclear localization and FXR/retinoic X receptor alpha association, culminating in small heterodimer protein promoter occupancy and activation in response to BA or FXR agonist. Conversely, accumulation of β‐catenin sequesters FXR, thus inhibiting its activation. Finally, exogenous suppression of β‐catenin expression during cholestatic injury reduces β‐catenin/FXR complex activation of FXR to decrease total BA and alleviate hepatic injury. Conclusion: We have identified an FXR/β‐catenin interaction whose modulation through β‐catenin suppression promotes FXR activation and decreases hepatic BAs, which may provide unique therapeutic opportunities in cholestatic liver diseases. (Hepatology 2018;67:955–971)
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
We perform a statistical study of the turbulent power spectrum at inertial and kinetic scales observed during the first perihelion encounter of the Parker Solar Probe. We find that often there is an ...extremely steep scaling range of the power spectrum just above the ion-kinetic scales, similar to prior observations at 1 A.U., with a power-law index of around − 4 . Based on our measurements, we demonstrate that either a significant ( > 50 % ) fraction of the total turbulent energy flux is dissipated in this range of scales, or the characteristic nonlinear interaction time of the turbulence decreases dramatically from the expectation based solely on the dispersive nature of nonlinearly interacting kinetic Alfvén waves.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM