The National Aeronautics and Space Administration Global‐scale Observations of the Limb and Disk ultraviolet spectrograph has been imaging the equatorial ionization anomaly (EIA), regions of the ...ionosphere with enhanced electron density north and south of the magnetic equator, since October 2018. The initial 3 months of observations was during solar minimum conditions, and they included observations in December solstice of unanticipated variability and depleted regions. Depletions are seen on most nights, in contrast to expectations from previous space‐based observations. The variety of scales and morphologies also pose challenges to understanding of the EIA. Abrupt changes in the EIA location, which could be related to in situ measurements of large‐scale depletion regions, are observed on some nights. Such synoptic‐scale disruptions have not been previously identified.
Plain Language Summary
In this study, ultraviolet images of emissions from the Earth's nighttime ionosphere were examined to determine the location of the equatorial ionization anomaly, regions of enhanced ionization that result in bands of nighttime airglow emission that typically appear parallel to the magnetic equator near +15° and −15° magnetic latitude. We found that gaps in the anomaly are observed much more frequently in these observations than in previous space‐based observations. These gaps, sometimes referred to as ionospheric bubbles or depletions, are important because they are associated with ionospheric changes that can cause disruptions in communications and satellite navigation that depend on satellites, such as GPS. The location of the anomaly was also observed to vary significantly, by as much as 15°, from the typical latitudes. The observed level of variability seen during the unusually quiet geomagnetic conditions during which the observations occurred suggests that accurate predictions of the location and variability of the equatorial ionization anomaly requires significant advances in understanding the causes of this variability.
Key Points
During geomagnetically quiet solar minimum conditions, significant temporal and spatial variability is observed in the equatorial ionosphere
At solar minimum, depleted ionospheric regions are observed on most nights, at varying longitudes, and with evident meridional symmetry
Synoptic‐scale disruptions of the ionization crests are seen on several nights, possibly associated with large‐scale plasma instabilities
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
We study the optical light curve (LC) relations of Type Ia supernovae (SNe Ia) for their use in cosmology using high-quality photometry published by the Carnegie Supernova Project (CSP-I). We revisit ...the classical luminosity decline rate (Δm15) relation and the Lira relation, as well as investigate the time evolution of the (B − V) color and B(B − V), which serves as the basis of the color-stretch relation and Color-MAgnitude Intercept Calibrations (CMAGIC). Our analysis is based on explosion and radiation transport simulations for spherically symmetric delayed-detonation models (DDT) producing normal-bright and subluminous SNe Ia. Empirical LC relations can be understood as having the same physical underpinnings, i.e., opacities, ionization balances in the photosphere, and radioactive energy deposition changing with time from below to above the photosphere. Some three to four weeks past maximum, the photosphere recedes to 56Ni-rich layers of similar density structure, leading to a similar color evolution. An important secondary parameter is the central density c of the WD because at higher densities, more electron-capture elements are produced at the expense of 56Ni production. This results in a Δm15 spread of 0.1 mag in normal-bright and 0.7 mag in subluminous SNe Ia and 0.2 mag in the Lira relation. We show why color-magnitude diagrams emphasize the transition between physical regimes and enable the construction of templates that depend mostly on Δm15 with little dispersion in both the CSP-I sample and our DDT models. This allows intrinsic SN Ia variations to be separated from the interstellar reddening characterized by E(B − V) and RB. Invoking different scenarios causes a wide spread in empirical relations, which may suggest one dominant scenario.
Initial Observations by the GOLD Mission Eastes, R. W.; McClintock, W. E.; Burns, A. G. ...
Journal of geophysical research. Space physics,
July 2020, Volume:
125, Issue:
7
Journal Article
Peer reviewed
Open access
The NASA Global‐scale Observations of the Limb and Disk (GOLD) mission has flown an ultraviolet‐imaging spectrograph on SES‐14, a communications satellite in geostationary orbit at 47.5°W longitude. ...That instrument observes the Earth's far ultraviolet (FUV) airglow at ~134–162 nm using two identical channels. The observations performed include limb scans, stellar occultations, and images of the sunlit and nightside disk from 6:10 to 00:40 universal time each day. Initial analyses reveal interesting and unexpected results as well as the potential for further studies of the Earth's thermosphere‐ionosphere system and its responses to solar‐geomagnetic forcing and atmospheric dynamics. Thermospheric composition ratios for major constituents, O and N2, temperatures near 160 km, and exospheric temperatures are retrieved from the daytime observations. Molecular oxygen (O2) densities are measured using stellar occultations. At night, emission from radiative recombination in the ionospheric F region is used to quantify ionospheric density variations in the equatorial ionization anomaly (EIA). Regions of depleted F region electron density are frequently evident, even during the current solar minimum. These depletions are caused by the “plasma fountain effect” and are associated with the instabilities, scintillations, or “spread F” seen in other types of observations, and GOLD makes unique observations for their study.
Plain Language Summary
The NASA Global‐scale Observations of the Limb and Disk (GOLD) mission has flown a dual‐channel, ultraviolet‐imaging spectrograph on SES‐14, a communications satellite in geostationary orbit at 47.5°W longitude. That instrument observes the Earth's far ultraviolet (FUV) airglow at ~134–162 nm. The observations performed include images of the Earth's sunlit and nightside disk, limb scans, and stellar occultations, from 6:10 to 00:40 universal time each day. Initial analyses reveal interesting and unexpected results as well as the potential for further studies of the Earth's thermosphere‐ionosphere system and its responses to solar‐geomagnetic forcing and atmospheric dynamics. Thermospheric temperatures and composition ratios for major constituents, O and N2, near 160‐km altitude and exospheric temperatures are retrieved from the daytime observations. Molecular oxygen (O2) densities are measured using stellar occultations. At night, emission from radiative recombination in the ionospheric F region is used to quantify ionospheric density variations in the equatorial ionization anomaly (EIA). Regions of depleted F region electron density are frequently evident in the EIA, even during the current solar minimum.
Key Points
GOLD makes global‐scale, synoptic measurements of the temperature, composition, and densities in the thermosphere‐ionosphere system
Most measurements by the GOLD instrument are made in one of four modes
The observations are providing new and surprising insights into the characteristics and behavior of the thermosphere and ionosphere
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Influenza and other respiratory viruses present a significant threat to public health, national security, and the world economy, and can lead to the emergence of global pandemics such as from ...COVID-19. A barrier to the development of effective therapeutics is the absence of a robust and predictive preclinical model, with most studies relying on a combination of in vitro screening with immortalized cell lines and low-throughput animal models. Here, we integrate human primary airway epithelial cells into a custom-engineered 96-device platform (PREDICT96-ALI) in which tissues are cultured in an array of microchannel-based culture chambers at an air-liquid interface, in a configuration compatible with high resolution in-situ imaging and real-time sensing. We apply this platform to influenza A virus and coronavirus infections, evaluating viral infection kinetics and antiviral agent dosing across multiple strains and donor populations of human primary cells. Human coronaviruses HCoV-NL63 and SARS-CoV-2 enter host cells via ACE2 and utilize the protease TMPRSS2 for spike protein priming, and we confirm their expression, demonstrate infection across a range of multiplicities of infection, and evaluate the efficacy of camostat mesylate, a known inhibitor of HCoV-NL63 infection. This new capability can be used to address a major gap in the rapid assessment of therapeutic efficacy of small molecules and antiviral agents against influenza and other respiratory viruses including coronaviruses.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Abstract
We present and analyze a near-infrared (NIR) spectrum of the underluminous Type Ia supernova SN 2020qxp/ASASSN-20jq obtained with NIRES at the Keck Observatory, 191 days after
B
-band ...maximum. The spectrum is dominated by a number of broad emission features, including the Fe
ii
at 1.644
μ
m, which is highly asymmetric with a tilted top and a peak redshifted by ≈2000 km s
−1
. In comparison with 2D non-LTE synthetic spectra computed from 3D simulations of off-center delayed-detonation Chandrasekhar-mass (
M
ch
) white dwarf (WD) models, we find good agreement between the observed lines and the synthetic profiles, and are able to unravel the structure of the progenitor’s envelope. We find that the size and tilt of the Fe
ii
1.644
μ
m profile (in velocity space) is an effective way to determine the location of an off-center delayed-detonation transition (DDT) and the viewing angle, and it requires a WD with a high central density of ∼4 × 10
9
g cm
−3
. We also tentatively identify a stable Ni feature around 1.9
μ
m characterized by a “pot-belly” profile that is slightly offset with respect to the kinematic center. In the case of SN 2020qxp/ASASSN-20jq, we estimate that the location of the DDT is ∼0.3
M
WD
off center, which gives rise to an asymmetric distribution of the underlying ejecta. We also demonstrate that low-luminosity and high-density WD SN Ia progenitors exhibit a very strong overlap of Ca and
56
Ni in physical space. This results in the formation of a prevalent Ca
ii
0.73
μ
m emission feature that is sensitive to asymmetry effects. Our findings are discussed within the context of alternative scenarios, including off-center C/O detonations in He-triggered sub-
M
Ch
WDs and the direct collision of two WDs. Snapshot programs with Gemini/Keck/Very Large Telescope (VLT)/ELT-class instruments and our spectropolarimetry program are complementary to mid-IR spectra by the James Webb Space Telescope (JWST).
Summary
Establishment of a community is considered to be essential for microbial growth and survival in the human oral cavity. Biofilm communities have increased resilience to physical forces, ...antimicrobial agents and nutritional variations. Specific cell‐to‐cell adherence processes, mediated by adhesin‐receptor pairings on respective microbial surfaces, are able to direct community development. These interactions co‐localize species in mutually beneficial relationships, such as streptococci, veillonellae, Porphyromonas gingivalis and Candida albicans. In transition from the planktonic mode of growth to a biofilm community, microorganisms undergo major transcriptional and proteomic changes. These occur in response to sensing of diffusible signals, such as autoinducer molecules, and to contact with host tissues or other microbial cells. Underpinning many of these processes are intracellular phosphorylation events that regulate a large number of microbial interactions relevant to community formation and development.
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BFBNIB, CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Molecular mechanisms underlying renal complications of diabetes remain unclear. We tested whether renal NADPH oxidase (Nox) 4 contributes to increased reactive oxygen species (ROS) generation and ...hyperactivation of redox-sensitive signaling pathways in diabetic nephropathy. Diabetic mice (db/db) (20 wk) and cultured mouse proximal tubule (MPT) cells exposed to high glucose (25 mmol/l, D-glucose) were studied. Expression (gene and protein) of Nox4, p22(phox), and p47(phox), but not Nox1 or Nox2, was increased in kidney cortex, but not medulla, from db/db vs. control mice (db/m) (P < 0.05). ROS generation, p38 mitogen-activated protein (MAP) kinase phosphorylation, and content of fibronectin and transforming growth factor (TGF)-β1/2 were increased in db/db vs. db/m (P < 0.01). High glucose increased expression of Nox4, but not other Noxes vs. normal glucose (P < 0.05). This was associated with increased NADPH oxidase activation and enhanced ROS production. Nox4 downregulation by small-interfering RNA and inhibition of Nox4 activity by GK-136901 (Nox1/4 inhibitor) attenuated d-glucose-induced NADPH oxidase-derived ROS generation. High d-glucose, but not l-glucose, stimulated phosphorylation of p38MAP kinase and increased expression of TGF-β1/2 and fibronectin, effects that were inhibited by SB-203580 (p38MAP kinase inhibitor). GK-136901 inhibited d-glucose-induced actions. Our data indicate that, in diabetic conditions: 1) renal Nox4 is upregulated in a cortex-specific manner, 2) MPT cells possess functionally active Nox4-based NADPH, 3) Nox4 is a major source of renal ROS, and 4) activation of profibrotic processes is mediated via Nox4-sensitive, p38MAP kinase-dependent pathways. These findings implicate Nox4-based NADPH oxidase in molecular mechanisms underlying fibrosis in type 2 diabetic nephropathy.
The Earth’s thermosphere and ionosphere constitute a dynamic system that varies daily in response to energy inputs from above and from below. This system can exhibit a significant response within an ...hour to changes in those inputs, as plasma and fluid processes compete to control its temperature, composition, and structure. Within this system, short wavelength solar radiation and charged particles from the magnetosphere deposit energy, and waves propagating from the lower atmosphere dissipate.
Understanding the global-scale response of the thermosphere-ionosphere
(
T-I
)
system to these drivers is essential to advancing our physical understanding of coupling between the space environment and the Earth’s atmosphere
. Previous missions have successfully determined how the “climate” of the T-I system responds. The Global-scale Observations of the Limb and Disk (GOLD) mission will determine how the “weather” of the T-I responds, taking the next step in understanding the coupling between the space environment and the Earth’s atmosphere. Operating in geostationary orbit, the GOLD imaging spectrograph will measure the Earth’s emissions from 132 to 162 nm. These measurements will be used image two critical variables—thermospheric temperature and composition, near 160 km—on the dayside disk at half-hour time scales. At night they will be used to image the evolution of the low latitude ionosphere in the same regions that were observed earlier during the day. Due to the geostationary orbit being used the mission observes the same hemisphere repeatedly, allowing the unambiguous separation of spatial and temporal variability over the Americas.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
ABSTRACT On 2014 December 9.61, the All-sky Automated Survey for SuperNovae (ASAS-SN or "Assassin") discovered ASASSN-14lp just ∼2 days after first light using a global array of 14 cm diameter ...telescopes. ASASSN-14lp went on to become a bright supernova (V = 11.94 mag), second only to SN 2014J for the year. We present prediscovery photometry (with a detection less than a day after first light) and ultraviolet through near-infrared photometric and spectroscopic data covering the rise and fall of ASASSN-14lp for more than 100 days. We find that ASASSN-14lp had a broad light curve ( ), a B-band maximum at 2457015.82 0.03, a rise time of days, and moderate host-galaxy extinction ( ). Using ASASSN-14lp, we derive a distance modulus for NGC 4666 of , corresponding to a distance of 14.7 1.5 Mpc. However, adding ASASSN-14lp to the calibrating sample of Type Ia supernovae still requires an independent distance to the host galaxy. Finally, using our early-time photometric and spectroscopic observations, we rule out red giant secondaries and, assuming a favorable viewing angle and explosion time, any nondegenerate companion larger than 0.34 .
Abstract
Radiative transfer models of two transitional type Ia supernovae (SNe Ia) have been produced using the abundance stratification technique. These two objects – designated SN 2007on and SN ...2011iv – both exploded in the same galaxy, NGC 1404, which allows for a direct comparison. SN 2007on synthesized 0.25 $\rm M_{{\odot}}$ of 56Ni and was less luminous than SN 2011iv, which produced 0.31 $\rm M_{{\odot}}$ of 56Ni. SN 2007on had a lower central density (ρc) and higher explosion energy (Ekin ∼1.3 ± 0.3 × 1051erg) than SN 2011iv, and it produced less nuclear statistical equilibrium (NSE) elements (0.06 $\rm M_{{\odot}}$). Whereas, SN 2011iv had a larger ρc, which increased the electron capture rate in the lowest velocity regions, and produced 0.35 $\rm M_{{\odot}}$ of stable NSE elements. SN 2011iv had an explosion energy of ∼Ekin ∼0.9 ± 0.2 × 1051erg. Both objects had an ejecta mass consistent with the Chandrasekhar mass (Ch-mass), and their observational properties are well described by predictions from delayed-detonation explosion models. Within this framework, comparison to the sub-luminous SN 1986G indicates SN 2011iv and SN 1986G have different transition densities (ρtr) but similar ρc. Whereas SN 1986G and SN 2007on had a similar ρtr but different ρc. Finally, we examine the colour–stretch parameter sBV versus Lmax relation and determine that the bulk of SNe Ia (including the sub-luminous ones) are consistent with Ch-mass delayed-detonation explosions, where the main parameter driving the diversity is ρtr. We also find ρc to be driving the second-order scatter observed at the faint end of the luminosity–width relationship.
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