How well do serum samples obtained from persons injected with the BNT162b2 vaccine neutralize the P.1, B.1.1.7, and B.1.135 lineages of SARS-CoV-2, first identified in Brazil, Britain, and South ...Africa, respectively? This study provides an answer.
Summary Approximately 27–37% of the people experienced prolonged sleep duration and 12–16% reported shortened sleep duration. However, prolonged or shortened sleep duration may be associated with ...serious health problems. A comprehensive, flexible, non-linear meta-regression with restricted cubic spline (RCS) was used to investigate the dose–response relationship between sleep duration and all-cause mortality in adults. Medline (Ovid), Embase, EBSCOhost—PsycINFO, and EBSCOhost—CINAHL Plus databases, reference lists of relevant review articles, and included studies were searched up to Nov. 29, 2015. Prospective cohort studies investigating the association between sleep duration and all-cause mortality in adults with at least three categories of sleep duration were eligible for inclusion. We eventually included in our study 40 cohort studies enrolling 2,200,425 participants with 271,507 deaths. A J-shaped association between sleep duration and all-cause mortality was present: compared with 7 hours of sleep (reference for 24-hour sleep duration), both shorted and prolonged sleep durations were associated with increased risk of all-cause mortality (4 hours: relative risk RR = 1.05; 95% confidence interval CI = 1.02–1.07; 5 hours: RR = 1.06; 95% CI = 1.03–1.09; 6 hours: RR =1.04; 95% CI = 1.03–1.06; 8 hours: RR = 1.03; 95% CI = 1.02–1.05; 9 hours: RR = 1.13; 95% CI = 1.10–1.16; 10 hours: RR = 1.25; 95% CI = 1.22–1.29; 11 hours: RR = 1.38; 95% CI = 1.33–1.44; n = 29; P < 0.01 for non-linear test). With regard to the night-sleep duration, prolonged night-sleep duration was associated with increased all-cause mortality (8 hours: RR = 1.01; 95% CI = 0.99–1.02; 9 hours: RR = 1.08; 95% CI = 1.04–1.11; 10 hours: RR = 1.24; 95% CI = 1.21–1.28; n = 13; P < 0.01 for non-linear test). Subgroup analysis showed females with short sleep duration a day (<7 h) were at high risk of all-cause mortality (4 hours: RR = 1.07; 95% CI = 1.02–1.13; 5 hours: RR = 1.08; 95% CI = 1.03–1.14; 6 hours: RR = 1.05; 95% CI = 1.02–1.09), but males were not (4 hours: RR = 1.01; 95% CI = 0.96–1.06; 5 hours: RR = 1.02; 95% CI = 0.97–1.08; 6 hours: RR = 1.02; 95% CI = 0.98–1.06). The current evidence suggests that insufficient or prolonged sleep may increase all-cause mortality. Women may be more susceptible to short sleep duration on all-cause mortality. Glossary of terms Restricted cubic spline: A smoothly joined piecewise polynomial with third-order polynomials fitted within each piecewise, which the left and (or) right tail of the curve are (is) restricted to linear. The joints of polynomials refer to knots. This function is usually used to fit the non-linear relationship.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, ...indicating that recognition by neutralizing antibodies may be compromised. We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B.1.351), Delta (B.1.617.2), or Omicron pseudoviruses with sera of 51 participants who received two or three doses of the messenger RNA (mRNA)-based COVID-19 vaccine BNT162b2. After two doses, Omicron-neutralizing titers were reduced >22-fold compared with Wuhan-neutralizing titers. One month after the third vaccine dose, Omicron-neutralizing titers were increased 23-fold relative to their levels after two doses and were similar to levels of Wuhan-neutralizing titers after two doses. The requirement of a third vaccine dose to effectively neutralize Omicron was confirmed with sera from a subset of participants using live SARS-CoV-2. These data suggest that three doses of the mRNA vaccine BNT162b2 may protect against Omicron-mediated COVID-19.
•The Precambrian basement tectonic frameworks of the Tarim block are reconstruction.•The Tarim Block can be divided into three main tectonic units during 800–900Ma.•The unified Tarim Block should be ...more large than the present Tarim basin.
Based on new petrographic observations and zircon U–Pb geochronological data of the Precambrian basement from deep drilling cores in the Tarim basin and comparison with the Precambrian basements surrounding orogenic belts of the Tarim basin, we reconstruct a possible unified Tarim block. Data presented in this contribution lead to a three-fold subdivision of the pre-900Ma basement of the Tarim block into the North Tarim terrane, the South Tarim terrane and the Central Tarim terrane. The North Tarim terrane containing Precambrian basements of the northern part of the Tarim basin, the Korla-Kuluketage and the Dunhuang area possesses a ca. 2.7–2.5Ga or an even older continental nucleus and underwent multiple phases of magmatic and metamorphic events at ca. 2.0–1.8Ga, 1.0–0.8Ga and 760–687Ma. The South Tarim terrane including Precambrian basements of the southern part of the Tarim basin, eastern Kunlun and western Kunlun orogenic belts, possesses a 2.4–2.3Ga continental nucleus and underwent 2.0–1.75Ga and 1.0–0.8Ga metamorphic and magmatic events. The Central Tarim terrane encompassing Precambrian basement of the central part of the Tarim basin and the Altun orogenic belt, is characterized by magmatic arc system during 940–890Ma. The unified Tarim Block was assembled as part of Rodinia supercontinent after series of geological processes, e.g. (1) breakup between the North and South Tarim terranes, (2) formation of the Central Tarim ocean, (3) subduction-related magmatic arc accretion, and (4) finally amalgamation of the North and South Tarim terranes during 1.0–0.8Ga. There are two phases of the middle Neoproterozoic magmatic activities at 820–760Ma and 760–687Ma, respectively. They were most possibly related to the two phases of the Rodinia plume activities. The late Mesoproterozoic to Sinian assembly and breakup of the Rodinia led to the typical double-layered structure of the Tarim Block, i.e. the Pre-Nanhuaian basement and the Nanhuaian to Sinian cover sequence. Based on this study, we suggest that the unified Tarim Block, composed of Precambrian basement of Tarim basin and its surrounding orogenic belts, should be more large than the present Tarim basin.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered ...transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents
. Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses-particularly the B.1.617.1 variant-seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally.
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GEOZS, IJS, IMTLJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK, ZAGLJ
The Hippo-YAP signaling pathway is altered and implicated as oncogenic in many human cancers. However, extracellular signals that regulate the mammalian Hippo pathway have remained elusive until very ...recently when it was shown that the Hippo pathway is regulated by G-protein-coupled receptor (GPCR) ligands including lysophosphatidic acid (LPA) and sphingosine 1-phosphophate (S1P). LPA inhibits Lats kinase activity in HEK293 cells, but the potential involvement of a protein phosphatase was not investigated. The extracellular regulators of YAP dephosphorylation (dpYAP) and nuclear translocation in epithelial ovarian cancer (EOC) are essentially unknown.
We showed here that LPA dose- and time-dependently induced dpYAP in human EOC cell lines OVCA433, OVCAR5, CAOV3, and Monty-1, accompanied by increased YAP nuclear translocation. YAP was involved in LPA-induced migration and invasion of EOC cells and LPA3 was a major LPA receptor mediating the migratory effect. We demonstrated that G13, but not or to a lesser extent G12, Gi or Gq, was necessary for LPA-induced dpYAP and its nuclear translocation and that RhoA-ROCK, but not RhoB, RhoC, Rac1, cdc42, PI3K, ERK, or AKT, were required for the LPA-dpYAP effect. In contrast to results in HEK293 cells, LPA did not inhibit Mst and Lats kinase in OVCA433 EOC cells. Instead, protein phosphatase 1A (PP1A) acted down-stream of RhoA in LPA-induction of dpYAP. In addition, we identified that amphiregulin (AREG), a down-stream target of YAP which activated EGF receptors (EGFR), mediated an LPA-stimulated and EGFR-dependent long-term (16 hr) cell migration. This process was transcription- and translation-dependent and was distinct from a transcription- and YAP-independent short-term (4 hr) cell migration. EOC tissues had reduced pYAP levels compared to normal and benign ovarian tissues, implying the involvement of dpYAP in EOC pathogenesis, as well as its potential marker and/or target values.
A novel LPA-LPA3-G13-RhoA-ROCK-PP1A-dpYAP-AREG-EGFR signaling pathway was linked to LPA-induced migration of EOC cells. Reduced pYAP levels were demonstrated in human EOC tumors as compared to both normal ovarian tissues and benign gynecologic masses. Our findings support that YAP is a potential marker and target for developing novel therapeutic strategies against EOC.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Abstract Large samples of Am and Ap stars are helpful in studying the interplay between phenomena like atomic diffusion, magnetic fields, and stellar rotation in stellar astrophysics. Existing ...samples of Am and Ap stars, mostly obtained from spectral data with a signal-to-noise ratio in the g band (S/Ng) greater than 50, can benefit from expansion by exploring spectra with lower S/Ng. Therefore, this paper proposes an ensemble regression model applicable to spectra with a minimum S/Ng of 30. Using the model, we identify 21,361 Am candidates, of which 11,614 are new, and 6182 Ap candidates, of which 4978 are new, from LAMOST DR10. The Am sample size has increased by 60% and the Ap sample size has increased by 180% compared to the previous sample. In terms of effective temperature ( T eff ), the Am candidates range mainly from 6000 to 8500 K, while the Ap candidates range from 6000 to 11,700 K. The surface gravity ( log g ) distributions for Am and Ap candidates differ in the range of 3.25–4.75 dex. The number of Am candidates increases stepwise, in contrast to the relatively uniform distribution of Ap candidates across the entire surface gravity range. Regarding metallicity (Fe/H), Am candidates typically range from −0.75 to 0.38 dex, peaking near 0 dex, while Ap candidates are distributed from −1.38 to 0.38 dex, with a peak near −0.5 dex.
We studied the benefits of peanut (Arachis hypogaea L.) intercropping (I) or relaycropping (R) with cowpea (Vigna unquiculata L.) and fertilizer application rates (unfertilized control, N; chemical ...fertilizer, C; organic manure, O; 50% C + 50% O, H) on soil biological properties of an Udic Mollisol. The crop multiple cropping and peanut monocropping (M) were established in 2002 and fertilizer was applied to any plots. We hypothesize that peanut/cowpea multiple cropping harbour a greater microfauna diversity, while organic mature application support a more complex soil food web and soil functioning. Combined the two factors implies a beneficial soil ecosystem for peanut production via repelling PPNs. The results showed microbial C and N over the growing season were 39.2% and 30.7% greater when peanut was intercropped and relaycropped than in monocropping plots. Total organic C, total N and alkali hydrolysable N were average 24.6%–43.1% greater when organic manure was applied than in the chemical fertilizer plots. Soil nematode community in peanut monocropping was dominated by plant parasites, mainly from Meloidogyne spp., but their abundance decreased when cowpea was associated to peanut. The cowpea also impacted other trophic groups. The proportion of bacterivores and high colonizer-persister (c-p) value omnivore-carnivores was increased in multi-cropping plots. The abundance of protozoa and fungivores were 36.9% and 29.8% greater in mixed manure plots than in no fertilization plots at flowering stage. The increased diversity indices (H′) and ecological indices (EI and SI) of the nematode communities indicated less disturbance and high soil fertility in multiple cropping systems. Overall, peanut multi-cropping with manure had a positive effect on peanut rhizosphere soil conditions.
•Multiple cropping with organic manure increases soil microfauna community diversity.•Multiple cropping strongly enhances protozoa abundance.•Bacterial and predator–prey pathways are dominant in organic manure practices.•Intercropping with moderate organic manure rates reduces plant parasites abundance.•Responses of soil nematodes to cropping and manure management are genus-dependent.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Abstract Existing research examines the impact of human resource (HR) practices on employee wellbeing by considering each practice in isolation or multiple practices as a bundle, focusing on linear ...associations. Drawing on the too‐much‐of‐a‐good‐thing (TMGT) meta‐theory, we examine possible nonlinear effects of Ability‐Motivation‐Opportunity (AMO) sub‐bundles on job satisfaction and job stress. We, also, examine boundary conditions on whether and how the nature of the identified curvilinear associations varies across employees in high‐, medium‐, and low‐skilled occupations. Using data from the Workplace Employment Relations Study (WERS2011), we uncover an inverse U‐shaped association between motivation‐enhancing (ME) practices and job satisfaction and a U‐shaped association between opportunity‐enhancing (OE) practices and job stress. No evidence of a curvilinear ability‐enhancing (AE) practices‐wellbeing association emerges. Additionally, occupational differences in skills levels moderate the curvilinear ME practices‐stress association. Likewise, occupational skills differences moderate the associations between OE practices and job satisfaction, and work stress. There is no suggestion that occupational differences moderate the AE practices‐wellbeing association. These findings underline the contingent nature of the TMGT effect and call for a more nuanced investigation of the HR‐wellbeing association.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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