This work presents the first multicentric, single arm, prospective study to evaluate the ability of MammoWave, a microwave imaging prototype, in breast lesions detection. This study was the first ...breast microwave imaging study during which both symptomatic and asymptomatic subjects were recruited. MammoWave output consists of a selection of microwave images' features, determined prior to the beginning of the trials, to quantify images' non-homogenous behavior. Our results on 382 breasts show a sensitivity of 82% using a statistical significance of p<0.05, indicating MammoWave's ability in distinguishing breasts with and without radiological findings. This prospective clinical trial may pave the way for introducing microwave imaging into clinical practice, for assisting in identification of breast lesions in asymptomatic women of all ages, without safety limitations.
Microwave imaging for breast cancer detection has attracted growing global attention with a small number of prototypes advancing to the clinical trial stage. This investigation aims to provide an ...overview of MammoWave, a novel microwave-based imaging system for breast lesion detection and to assess its introduction into the clinical routine and its potential role in future breast screening programs. As a key focus of this work, we will describe in detail the various aspects of the clinical protocol procedure that has enabled us to perform a successful clinical trial. Obtained preliminary results indicate the ability of our device to distinguish breasts with no radiological finding and those with radiological findings, with a sensitivity of 89.6%.
This paper describes an integrated webGIS system dedicated to the central Mediterranean region surrounding Sicily, contributing to the Marine Hazard Project. The webGIS system aims at integrating ...information from in situ and remote sensing measurements made at the Observatories at Lampedusa and Capo Granitola, in Sicily, and from satellite products distributed by the Copernicus Marine Environment Monitoring Service. The background structure of the webGIS system, the contributing datasets, and an example case study are described in this work.
Loin des feux qui ont fait jadis sa gloire, le cinéma des pays arabes se réinvente sous l’effet de dynamiques de production et d’exposition des films, dans des expérimentations visuelles inédites et ...dans un nouveau rapport à la prise et à la consommation d’images. Ce sont ces mutations et ce qu’elles disent de ce territoire, qui va de l’Atlantique au Golfe, que ce recueil explore. Par l’étude des œuvres, des conditions de production des films, de leur circulation et de leur réception, le cinéma permet en effet aussi d’interroger les évolutions sociales et politiques à l’œuvre dans cette région du monde. La première partie de cet ensemble est construite autour des notions de territoire et de frontière. Celles-ci concernent aussi bien les nouvelles logiques de production et d’exposition de films dans les festivals que l’effacement des frontières entre champs artistiques, et bien entendu la façon dont les films eux-mêmes prennent en charge de multiples manières les questions de représentation territoriale. La seconde partie s’attache à la représentation du pouvoir dans les films et aux liens tissés entre pouvoirs et cinéma au cours de ces dix dernières années. A travers les bouleversements filmés et mis en scène durant les Printemps arabes (voire même avant), cette partie traite bien évidemment du rapport entre cinéma et révolution, mais elle questionne aussi les rapports de pouvoir quand celui-ci se situe à d’autres niveaux, entre les hommes et les femmes, entre les producteurs et les réalisateurs, entre les spectateurs et le film. Elle interroge tout autant la façon dont des partis politiques ou des médias utilisent le film pour accroître leur influence qu’à l’inverse, l’action du cinéma lui-même sur les pouvoirs politiques et sur leurs évolutions. Cette partie s’achève sur une réflexion qui, partant des territoires arabes et des contestations politiques avec et par l’image, interroge de façon plus ample ce qui définit le cinéma au regard des autres images au xxiesiècle.
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign tumor that usually involves the upper or lower jaw, but it may also arise in other sites. We describe a case of MNTI located in the ...left epididymis of a 6-month-old boy. Left orchiectomy was performed. Immunohistochemical and ultrastructural studies revealed two types of cells: small, poorly differentiated cells that were positive for neuron-specific enolase protein and vimentin, and larger epithelial cells that were positive for melanoma antigen (HMB45) and frequently contained large and elongated melanosomes, similar to those described in retinal pigmented epithelium. At 12 months of follow-up, no recurrences or metastases were seen. Primary involvement of the epididymis has been previously reported in only 16 cases. Immunohistochemical and ultrastructural studies suggest that the neoplasm is of neural crest origin.
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IJS, IMTLJ, KILJ, KISLJ, NUK, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Objectives Translaryngeal tracheotomy (TLT) is a widely accepted procedure in intensive‐care units for its simplicity of execution, low morbidity, rapid wound closure after cannula removal, good ...esthetic results, and lack of long‐term sequelae. The aim of this study was to evaluate the feasibility and use of adopting TLT in patients with cancer undergoing major head and neck surgery.
Study Design Prospective analysis of learning curve and incidence of complications in 41 patients with cancer who underwent TLT at the Division of Head and Neck Surgery of the European Institute of Oncology from November 1997 to June 1999.
Methods Patient characteristics, pathology, anatomic characteristics of the neck, and surgical short‐term and long‐term complications were noted. The patients were divided into consecutive groups of six or seven patients, and time trends in occurrence of complications and time to execute the procedure were assessed.
Results TLT performance time decreased from 50 minutes in the first seven patients to 24 minutes in the last group. The technique was easy to perform and safe, with only two minor complications during surgery. However, minor complications occurred in three and major complications in 17 patients in the days immediately following surgery, almost entirely attributable to lack of counter‐cannu1a and stylet.
Conclusions In view of the high proportion of major complications, TLT using the presently available kit is unsuitable for major head and neck surgery. However, the considerable advantages of the technique would recommend it as a valid alternative to surgical tracheotomy if the kit included a counter‐cannu1a and stylet.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The Italian Scientific Associations of Cardiologists and Cardiovascular Pathologists have produced this consensus document on the diagnostic role of endomyocardial biopsy (EMB) in terms of ...techniques, analysis and reporting. The document is intended for clinical cardiologists, hemodynamic experts, electrophysiologists, surgical pathologists, and cardiac surgeons. It has three main aims: a) to collocate EMB in the context of currently available tools for diagnosis of heart diseases; b) to provide recommendations for rational implementation; c) to outline key characteristics (standards) for Italian cardiology and surgical pathology centers that perform and analyze EMB. A general lack of prospective, controlled studies addressing EMB prohibited the use of traditional evidence-based recommendations that rely on classes of available evidence. Thus, it was agreed that three key points should be taken into account: a) the specific pathology to be diagnosed (or excluded); b) the existence of any alternative, non-invasive diagnostic techniques; c) the overall consequences of reaching a definite diagnosis on patients' clinical management. Accordingly, we propose recommendations for EMB based on the following levels of diagnostic value: level 1: no alternative method exists to reach a definite diagnosis that can have obvious consequences for clinical management; level 2a: no alternative method exists to reach a definite diagnosis; however, the implications for clinical management are uncertain; level 2b: no alternative method exists to reach a definite diagnosis; however, the diagnosis would not influence clinical management; level 3: an alternative method exists to reach a definite diagnosis. The second part of the document proposes current protocols for the preparation, analysis and reporting of EMB in the context of each main pathologic entity. Particular attention is given to tissue characterization and implementation of molecular tests.
