This article compares an interspecies moment in Howard Thurman’s classic text, Jesus and the Disinherited, and Gwendolyn Brook’s novella, Maud Martha, to consider how Black liberation theology might ...reimagine the animal-human binarism it has assumed from the Western Philosophical tradition. I contend that an animal-human binarism attenuates the liberationist ethos of black theology, particularly when the animal is centered. To explore this, I first parse out the theological anthropology of Black liberation theology to demonstrate how it has historically occupied a complicated relationship to Western depictions of the human. Then, I argue on the grounds of its own theological convictions, that black theology is obligated to move beyond this ambivalence. As an example, I assess Howard Thurman’s classic essay to discover what insights might be revealed if we reconsider his reading of the mouse’s squeal, considering a comparison to a similar encounter between a human and a pest in Gwendolyn Brook’s novella, Maud Martha. This comparison reveals that Thurman may very well be limited in his capacity to recognize something in the mouse’s defiance. On the other hand, Brooks’ ecowomanist lens may better affirm the defiant mouse. Maud Martha identifies with the mouse so much that she, in contrast to Thurman, spares its life. This moment resulted in her undergoing an unexpected spiritual experience. This experience, according to my reading, is an example of what I am describing as “catching a glimpse” of a liberating deity’s interiority or, what I am considering as a new relation with divine immanence. In other words, in sparing the animal, in seeing the animal as of equal significance, she consequently felt a connection with God. This moment of liberation and divine connection is the ultimate aim of Black liberation theology. An aim we can try to reach by including the animal into our liberationist objective.
ABSTRACT
This article analyzes the unpublished dialogue between James Baldwin and Reinhold Niebuhr where they discussed the role of the Christian church in the wake of six child murders in ...Birmingham, Alabama on September 15, 1963. On that catastrophic day—one that is impossible to forget—the Ku Klux Klan bombed The Sixteenth Street Baptist Church, and two black boys were subsequently shot and killed. In the wake of that violence, this article will show that for Baldwin, the dynamite that exploded the face of the “alabaster Christ” from the stained‐glass window presents an opportunity for not only a new depiction of Jesus in terms of presentation—but more significantly—a brand‐new Christology rooted in black liberation. Such a reading provides us with an unusual constructive theological position offered by Baldwin, especially once it is read alongside a public essay written by the Association of Artists for Freedom advocating for Black Christmas.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
C-C chemokine receptor 7 (CCR7) controls lymphocyte migration to secondary lymphoid organs. Although CCR7 has been implicated in targeting the metastasis of cancers to lymph nodes, the role of CCR7 ...in the metastasis of breast cancer, along with the molecular mechanisms that are controlled by CCR7 that target breast cancer metastasis to the lymph nodes, has yet to be defined. To explore the cellular and molecular mechanisms of breast cancer cell migration to the lymph nodes, we used the mouse MMTV-PyVmT mammary tumor cells (PyVmT) transfected with CCR7 and the human CCR7-expressing MCF10A and MCF7 mammary cell lines. We found that the CCR7 ligands CCL19 and CCL21, controlled cell migration using the β1-integrin heterodimeric adhesion molecules. To define a physiological significance for CCR7 regulation of migration, we used the FVB syngeneic mouse model of metastatic breast cancer. When CCR7-negative PyVmT cells transfected with control vector were orthotopically transferred to the mammary fat pad of FVB mice, tumors metastasized to the lungs (10/10 mice) but not to the lymph nodes (0/10). In contrast, CCR7-expressing PyVmT (CCR7-PyVmT) cells metastasized to the lymph nodes (6/10 mice) and had a reduced rate of metastasis to the lungs (4/10 mice). CCR7-PyVmT tumors grew significantly faster than PyVmT tumors, which mirrored the growth in vitro, of CCR7-PyVmT, MCF7, and MCF10A mammospheres. This model provides tools for studying lymph node metastasis, CCR7 regulation of tumor cell growth, and targeting of breast cancer cells to the lymph nodes.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
We analyzed high-angular rate streaks first recorded by OSIRIS-REx’s MapCam during a 2017 search for Earth Trojan asteroids. We interpret them as water-ice particles that translated across the ...imager’s field of view, originating from the spacecraft itself. Their translation velocities approximated 0.1–1 m/s based on reasonable conclusions about their range. Pursuing several lines of investigation to seek a coherent hypothesis, we conclude that the episodic releases of the water ice particles are associated with spacecraft attitudes that resulted in solar illumination of previously shadowed regions. This correlation suggests that the OSIRIS-REx spacecraft itself possesses micro-climatic zones consisting of hot regions and cold traps that may temporarily potentially pass volatiles back and forth before losing most of them.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
CCR7 binds to its cognate ligand, CCL21, to mediate the migration of circulating naive T lymphocytes to the lymph nodes. T lymphocytes can bind to fibronectin, a constituent of lymph nodes, via their ...β1 integrins, which is a primary mechanism of T lymphocyte migration; however, the signaling pathways involved are unclear. We report that rapid (within 2 min) and transient phosphorylation of ERK1/2 is required for T cell migration on fibronectin in response to CCL21. Conversely, prevention of ERK1/2 phosphorylation by inhibition of its kinase, MAPK/MEK, prevented T lymphocyte migration. Previous studies have suggested that phospholipase Cγ1 (PLCγ1) can mediate phosphorylation of ERK1/2, which is required for β1 integrin activation. Paradoxically, we found that inhibition of PLCγ1 phosphorylation by the general PLC inhibitor U73122 was associated with a delayed and reduced phosphorylation of ERK1/2 and reduced migration of T lymphocytes on fibronectin. To further characterize the relationship between ERK1/2 and PLCγ1, we reduced PLCγ1 levels by 85% using shRNA and observed a reduced phosphorylation of ERK1/2 and a significant loss of CCR7-mediated migration of T lymphocytes on fibronectin. In addition, we found that inhibition of ERK1/2 phosphorylation by U0126 resulted in a decreased phosphorylation of PLCγ1, suggesting a feedback loop between ERK1/2 and PLCγ1. Overall, these results suggest that the CCR7 signaling pathway leading to T lymphocyte migration on fibronectin is a β1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCγ1.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Internalization of ligand bound G protein-coupled receptors, an important cellular function that mediates receptor desensitization, takes place via distinct pathways, which are often unique for each ...receptor. The C-C chemokine receptor (CCR7) G protein-coupled receptor is expressed on naive T cells, dendritic cells, and NK cells and has two endogenous ligands, CCL19 and CCL21. Following binding of CCL21, 21 +/- 4% of CCR7 is internalized in the HuT 78 human T cell lymphoma line, while 76 +/- 8% of CCR7 is internalized upon binding to CCL19. To determine whether arrestins mediated differential internalization of CCR7/CCL19 vs CCR7/CCL21, we used small interfering RNA (siRNA) to knock down expression of arrestin 2 or arrestin 3 in HuT 78 cells. Independent of arrestin 2 or arrestin 3 expression, CCR7/CCL21 internalized. In contrast, following depletion of arrestin 3, CCR7/CCL19 failed to internalize. To examine the consequence of complete loss of both arrestin 2 and arrestin 3 on CCL19/CCR7 internalization, we examined CCR7 internalization in arrestin 2(-/-)/arrestin 3(-/-) murine embryonic fibroblasts. Only reconstitution with arrestin 3-GFP but not arrestin 2-GFP rescued internalization of CCR7/CCL19. Loss of arrestin 2 or arrestin 3 blocked migration to CCL19 but had no effect on migration to CCL21. Using immunofluorescence microscopy, we found that arrestins do not cluster at the membrane with CCR7 following ligand binding but cap with CCR7 during receptor internalization. These are the first studies that define a role for arrestin 3 in the internalization of a chemokine receptor following binding of one but not both endogenous ligands.
CCR7 binds to its cognate ligand, CCL21, to mediate the migration of circulating naive T lymphocytes to the lymph nodes. T lymphocytes can bind to fibronectin, a constituent of lymph nodes, via their ...beta 1 integrins, which is a primary mechanism of T lymphocyte migration; however, the signaling pathways involved are unclear. We report that rapid (within 2 min) and transient phosphorylation of ERK1/2 is required for T cell migration on fibronectin in response to CCL21. Conversely, prevention of ERK1/2 phosphorylation by inhibition of its kinase, MAPK/MEK, prevented T lymphocyte migration. Previous studies have suggested that phospholipase C gamma 1 (PLC gamma 1) can mediate phosphorylation of ERK1/2, which is required for beta 1 integrin activation. Paradoxically, we found that inhibition of PLC gamma 1 phosphorylation by the general PLC inhibitor U73122 was associated with a delayed and reduced phosphorylation of ERK1/2 and reduced migration of T lymphocytes on fibronectin. To further characterize the relationship between ERK1/2 and PLC gamma 1, we reduced PLC gamma 1 levels by 85% using shRNA and observed a reduced phosphorylation of ERK1/2 and a significant loss of CCR7-mediated migration of T lymphocytes on fibronectin. In addition, we found that inhibition of ERK1/2 phosphorylation by U0126 resulted in a decreased phosphorylation of PLC gamma 1, suggesting a feedback loop between ERK1/2 and PLC gamma 1. Overall, these results suggest that the CCR7 signaling pathway leading to T lymphocyte migration on fibronectin is a beta 1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLC gamma 1.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
T lymphocytes circulate between the blood, tissues, and lymph. These T cells carry out immune functions, using the C-C chemokine receptor 7 (CCR7) and its cognate ligands, CCL19 and CCL21, to enter ...and travel through the lymph nodes. Distinct roles for each ligand in regulating T lymphocyte trafficking have remained elusive. We report that in the human T cell line HuT78 and in primary murine T lymphocytes, signaling from CCR7/CCL19 leads to increased expression and phosphorylation of extracellular signal-regulated kinase 5 (ERK5) within eight hours of stimulation. Within 48–72 h we observed peak levels of endothelial differentiation gene 1 (EDG-1), which mediates the egress of T lymphocytes from lymph nodes. The increased expression of EDG-1 was preceded by up-regulation of its transcription factor, Krüppel-like factor 2 (KLF-2). To determine the cellular effect of disrupting ERK5 signaling from CCR7, we examined the migration of ERK5flox/flox/Lck-Cre murine T cells to EDG-1 ligands. While CCL19-stimulated ERK5flox/flox naïve T cells showed increased migration to EDG-1 ligands at 48 h, the migration of ERK5flox/flox/Lck-Cre T cells remained at a basal level. Accordingly, we define a novel signaling pathway that controls EDG-1 up-regulation following stimulation of T cells by CCR7/CCL19. This is the first report to link the two signaling events that control migration through the lymph nodes: CCR7 mediates entry into the lymph nodes and EDG-1 signaling controls their subsequent exit.
Background: CCL19 ligand controls signaling events in T cells.
Results: CCL19 promotes up-regulation of ERK5 to regulate KLF-2, which leads to expression of EDG-1.
Conclusion: CCL19 stimulation of naïve T cells regulates expression of ERK5, KLF-2, and EDG-1.
Significance: CCL19 links the control of expression of EDG-1 in naïve T cells that mediate T cell entry to, and exit from, lymph nodes.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Taking the Hagar story as the central biblical resource to address the particular plight of Black women—a plight that reckons with patriarchal and White supremacist forces that desire its ...enclosure—Delores Williams challenges both the traditional understanding of atonement theory which embraces the Cross as salvific and Black liberation theologies’ apocalyptical conceptions of a mighty liberating God. This article seeks to read Delores Williams closely to take seriously her theological development through literature more broadly and her soteriological critiques of the Cross specifically. A rereading of Williams will provide the grounds for continuing the debate of the Cross’s (in)significance within Black theological thought at large. Analyzing Williams’ soteriological critiques will allow me to offer a reading of the Cross that ultimately relies on Williams’ emphatic rejection. Such a rejection of the Cross is necessary for understanding how Black Christianity centers the Cross in order to reject it, as it is intended to be.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
There has been much criticism - and an overall unfortunate dismissal - of William R. Jones' Is God A White Racist?: A Preamble to Black Theology (1973) in the literature of Black liberation theology. ...What is undertheorized, however, is the constructive possibilities of Jones' work. Analyzing the theological debate between Jones and James H. Cone provides us with the necessary material in order to construct a Black theology that commences with the assumptions of Jones' theodicy. I argue that theodicy is a useful "controlling category" for Black liberation theology, but only - and here I am following Kant - as a result of how its collapses rational arguments for believing in God/liberation. And it is precisely this failure that makes it profoundly useful as an avenue into understanding the contours of "Black faith" that undergirds Black liberation theology.
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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