With spring up of infrared imaging related industry, infrared imaging technology has become mainstream development direction of intelligent photoelectrical detection due to its good concealment, wide ...detection range, high positioning accuracy, long distant penetration, light weight, little volume, low power dissipation and high solidity. However, the features of infrared dim-small target image such as less details and low SNR become bottleneck of infrared image application. How to enhance imaging effect of infrared dim-small target becomes research hotspot. Starting from the point of 'restoration as foundation', the theory and technology of infrared dim-small target super-resolution restoration by utilizing the theory and technology of super-resolution restoration are explored in this paper. This paper mainly focuses on the research of super-resolution restoration algorithm of infrared dim-small target based on infrared micro-scanning optical model. Aiming at solving super-resolution restoration problem of infrared dim-small target, the traditional super-resolution restoration algorithm is optimized and the improved algorithm is proposed. Meanwhile, infrared micro-scanning optical model is introduced to break theoretical limit of simple image processing algorithm. And the performance of infrared image super-resolution restoration is improved.
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Superlithiation has been observed in some carbonyl-based organic electrodes, which leads to very high battery capacity. However, as typical carbonyl polymers, polyimides (PIs) exhibited a relatively ...low capacity (≤250 mA h g −1 ) in previous studies because their poor electrical conductivity restricts superlithiation. Therefore, to realize superlithiation, in this study, multilayer graphene (MG) as a conductive additive was incorporated in PI matrix through a blending precipitation and thermal imidization method. As an electrode in lithium-ion batteries, PI–MG exhibited outstanding capacity (612 mA h g −1 at 100 mA g −1 ) and stable long-term cyclability (89.3% capacity retention over 500 cycles at 500 mA g −1 ). Moreover, the battery could be operated stably at various temperatures, and it exhibited very high specific capacity, especially at the high operating temperature of 55 °C (873 mA h g −1 , 0.1C). We believe that this strategy of introducing conductive additives to promote superlithiation is highly applicable to other non-conductive carbonyl polymers for lithium-ion battery applications.
This study aimed to investigate the effect of saxagliptin on the injury of Alzheimer's disease (AD) cell model and its possible mechanism. SK-N-SH cells were cultured in vitro and divided into CON ...group, AD group, AD+L-SAX group, AD+M-SAX group, AD+H-SAX group, AD+anti-miR-NC group, AD+anti-miR-483-5p group, AD+SAX+miR-NC group and AD+SAX+miR-483-5p group. Then the levels of MDA, SOD and GSH-Px in each group were detected by ELISA method; cell apoptosis was detected by flow cytometry; the protein expression levels of Bax and Bcl-2 were detected by Western Blot; the expression level of miR-483-5p was detected by RT-qPCR. Compared with the control group, MDA content, apoptosis rate, and the expression of Bax protein and miR-483-5p increased in the AD group (P<0.05), while the activity of SOD and GSH-Px and the expression of Bcl-2 protein decreased (P<0.05). Compared with the AD group, MDA content, apoptosis rate, and the expression of Bax protein and miR-483-5p decreased in the AD+L-SAX group, AD+M-SAX group and AD+H-SAX group (P<0.05), while the activity of SOD and GSH-Px and the expression of Bcl-2 protein increased (P<0.05). Compared with AD+anti-miR-NC group, MDA content, apoptosis rate, and the expression of Bax protein and miR-483-5p decreased in the AD+anti-miR-483-5p group (P<0.05), while the activity of SOD and GSH-Px and the expression of Bcl-2 protein increased (P<0.05). Compared with AD+SAX+miR-NC group, MDA content, apoptosis rate, and the expression of Bax protein and miR-483-5p increased in the AD+SAX+miR-483-5p group (P<0.05), while the activity of SOD and GSH-Px and the expression of Bcl-2 protein decreased (P<0.05). Saxagliptin may reduce the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p.
Tumor-associated neutrophils (TANs) are important inflammatory infiltrating cells in the tumor microenvironment and are closely related to the development of human tumor. However, the underlying ...mechanism of TANs recruiting to glioma remains unknown. Herein, we identified that LINC01116 was significantly upregulated in glioma, and positively correlated with clinical malignancy and survival prognosis. LINC01116 regulated the progression of glioma in vitro and in vivo. RNA-seq analysis demonstrated that LINC01116 knockdown affected the expression of IL-1β, which promoted glioma proliferation and neutrophil recruitment. Furthermore, the co-culture of glioma cells and neutrophils showed that the accumulation of TANs promoted tumor proliferation via producing a host of cytokines. Mechanistically, LINC01116 activated IL-1β expression by recruiting the transcriptional regulator DDX5 to the IL-1β promoter. Our findings reveal that LINC01116 can promote glioma proliferation and neutrophil recruitment by regulating IL-1β, and may be served as a novel target for glioma therapy and prognosis.
Abstract Introduction The purpose of this study was to compare the effectiveness of mineral trioxide aggregate (MTA) and calcium hydroxide (CH) as pulp capping materials in humans by means of a ...meta-analysis. Methods The PubMed, Cochrane Library, Embase, and Web of Knowledge databases were used in the literature search from their establishment date until December 7, 2014. Studies that met the inclusion criteria were accepted, and necessary information was extracted by 2 authors independently using a standardized form. The success rate, inflammatory response, and dentin bridge formation were evaluated. Results Thirteen studies met the inclusion criteria. There was no significant heterogeneity between studies, so a fixed-effects model was used. The MTA treatment groups showed a significantly higher success rate compared with CH-capped groups (randomized controlled trials: odds ratio OR = 2.26; 95% confidence interval CI = 1.33–3.85; P = .003; retrospective nonrandomized trials: OR = 2.88; 95% CI, 1.86–4.44; P < .00001). MTA was superior to CH in terms of the absence of an inflammatory response as well as dentin bridge formation, with the OR being 4.56 (95% CI, 2.65–7.83) and 3.56 (95% CI, 1.89–6.70), respectively. Conclusions MTA has a higher success rate and results in less pulpal inflammatory response and more predictable hard dentin bridge formation than CH. MTA appears to be a suitable replacement of CH used for direct pulp capping.
A three-dimensional simulation model of multi-stage high temperature and pressure reducing valve (MSHTPRV) was established via the combination of Euler-Lagrange two-phase flow and droplet evaporation ...model. The simulation model was verified by a DN10 temperature and pressure reducing valve (TPRV) experiment. Then the vapor-liquid two-phase flow model with droplet evaporation was applied to the MSHTPRV. The complex flow and working performance of the MSHTPRV are demonstrated. The key influence of water spray parameters on the flow characteristics and thermodynamic loss was analyzed. The results show that the steam flow evolves the strong vortex in front of each stage orifice, and the droplet evaporates faster in the large vortex. The entropy production in MSHTPRV is mainly from the vortex motion and droplet evaporation. With the increasing of droplet diameter, the evaporation rate of droplet decreases, and the steam work capacity loss decreases. When the injection velocity of droplet exceeds the steam velocity, the evaporation rate of droplet can be increased. The increasing of injection temperature leads to the decreasing of steam work capacity loss. The latent heat of vaporization absorbed by the droplet is the main mechanism to reduce the steam temperature, and the evaporation of smaller droplet diameter can produce more steam work capacity loss.
•Euler-Lagrange two-phase flow and droplet evaporation is verified by experiment.•Flow characteristics and thermodynamic loss of MSHTPRV was analyzed.•Influence of water spray parameters on MSHTPRV performance was analyzed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Background Cervical cancer ranks as the second most fatal tumour globally among females. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been widely applied to the ...diagnosis of cancers.Methods The clinicopathologic data of 180 patients with stage IB2-IIB cervical cancer who underwent radical concurrent chemoradiotherapy from January 2018 to December 2019 were retrospectively analysed. Receiver operating characteristic (ROC) curves were plotted to analyse the optimal cut-off values of NLR and PLR for predicting the therapeutic effects of concurrent chemoradiotherapy. The associations of PLR and other clinicopathological factors with 1-year survival rates were explored through univariate analysis and multivariate Cox regression analysis, respectively.Results NLR was significantly associated with the therapeutic effects of neoadjuvant therapy, with the optimal cut-off value of 2.89, area under the ROC curve (AUC) of 0.848 (95% confidence interval CI: 0.712–0.896), sensitivity of 0.892 (95% CI: 0.856–0.923) and specificity of 0.564 (95% CI: 0.512–0.592). PLR had a significant association with the therapeutic effects of neoadjuvant therapy, with the optimal cut-off value of 134.27, AUC of 0.766 (95% CI: 0.724–0.861), sensitivity of 0.874 (95% CI: 0.843–0.905) and specificity of 0.534 (95% CI: 0.512–0.556). Lymphatic metastasis (95% CI: 1.435–5.461, 95% CI: 1.336–4.281, depth of invasion (95% CI: 1.281–3.546, 95% CI: 1.183–3.359) and tumour size (95% CI: 1.129–3.451, 95% CI: 1.129–3.451) were independent factors influencing the overall survival and disease-free survival (DFS) of patients with cervical cancer. NLR (95%CI: 1.256-4.039) and PLR (95%CI:1.281-3.546) were also independent factors affecting DFS.Conclusion NLR and PLR in the peripheral blood before treatment may predict DFS of patients with stage IB2-IIB cervical cancer.
There is an on-going demand in recent years for safer and "greener" hair coloring agents with the global consumer awareness of the adverse effects of synthetic hair dyes. The belief in sustainability ...and health benefits has focused the attention of the scientific community towards natural colorants that serve to replace their synthetic toxic counterparts. This review article encompasses the historical applications of a vast array of natural plant hair dyes and summarizes the possible coloration mechanisms (direct dyeing and mordant dyeing). Current information on phytochemicals (quinones, tannins, flavonoids, indigo, curcuminoids and carotenoids) used for hair dyeing are summarized, including their botanical sources, color chemistry and biological/toxicological activities. A particular focus is given on research into new natural hair dye sources along with eco-friendly, robust and cost-effective technologies for their processing and applications, such as the synthetic biology approach for colorant production, encapsulation techniques for stabilization and the development of inorganic nanocarriers. In addition, innovative in vitro approaches for the toxicological assessments of natural hair dye cosmetics are highlighted.
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To obtain high-precision for focal length fitting and improve the visible-light camera autofocusing speed, simultaneously, the backlash caused by gear gaps is eliminated. We propose an improved RBF ...(Radical Basis Function) adaptive neural network (ANN) FUZZY PID (Proportional Integral Derivative) position closed-loop control algorithm to achieve the precise positioning of zoom and focus lens groups. Thus, the Levenberg-Marquardt iterative algorithm is used to fit the focal length, and the improved area search algorithm is applied to achieve autofocusing and eliminate backlash. In this paper, we initially adopt an improved RBF ANN fuzzy PID control algorithm in the position closed-loop in the visible-light camera position and velocity double closed-loop control system. Second, a similar triangle method is used to calibrate the focal length of the visible-light camera system, and the Levenberg-Marquardt iterative algorithm is used to fit the relation of the zoom potentiometer code values and the focal length to achieve the zoom position closed-loop control. Finally, the improved area search algorithm is used to achieve fast autofocusing and acquire clear images. The experimental results show that the ITAE (integrated time and absolute error) performance index of the improved RBF ANN fuzzy PID control algorithm is improved by more than two orders of magnitude as compared with the traditional fuzzy PID control algorithm, and the settling time is 6.4 s faster than that of the traditional fuzzy PID control. Then, the Levenberg-Marquardt iterative algorithm has a fast convergence speed, and the fitting precision is high. The quintic polynomial fitting results are basically consistent with the sixth-degree polynomial. The fitting accuracy is much better than that of the quadratic polynomial and exponential. Autofocusing requires less than 2 s and is improved by more than double that of the traditional method. The improved area search algorithm can quickly obtain clear images and solve the backlash problem.
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