The evaluation of quality of life related to health (HRQOL) has become an important prognostic indicator in HIV/AIDS. The aim of this study was to determine the impact of socio-demographic, clinical ...and psychological factors in HRQOL in a group of subjects with HIV/AIDS in northwestern Mexico and determine which variables best predict HRQOL.
In a cross-sectional study with a sample of 87% of patients receiving care at a clinic for HIV/AIDS in northwestern Mexico between November 2010 to June 2011, we measure the HRQOL using the Tool Medical Outcomes Study HIV Health Survey (MOS-HIV). A model of multiple linear regression was performed to identify variables that allow us to predict HRQOL in this population.
In a sample of 54 subjects with HIV/AIDS. Patients had an average age of 43 ± 9 years, 83% were men with a mean time of 6.5 ± 4.5 years from diagnosis. HRQOL scores of physical and mental health of the participants were 57 ± 6 and 57 ± 13 respectively. In multivariate analysis, the variables that influenced the physical health punctuation were gender, marital status, sexual orientation, time since diagnosis and viral load (log).
Prospective studies are needed to better explain the influence of the factors that predict changes or trends in HRQOL in patients with HIV/AIDS.
Since 2015 Brazil has experienced the social repercussions of the Zika virus epidemic, thus raising a debate about: difficulties of diagnosis; healthcare access for children with Zika Congenital ...Syndrome (ZCS); the search for benefits by affected families; social and gender inequalities; and a discussion on reproductive rights, among others. The objective of this article is to analyse access to specialized health services for the care of children born with ZCS in three North-eastern states of Brazil. This is an exploratory cross-sectional study which analyses recorded cases of microcephaly at the municipal level between 2015 and 2017. Most of the cases of ZCS were concentrated on the Northeast coast. Rio Grande do Norte and Paraiba had the highest incidence of microcephaly in the study period. The states of Bahia, Paraiba and Rio Grande do Norte were selected for their high incidence of microcephaly due to the Zika Virus. Socio-territorial vulnerability was stratified using access to microcephaly diagnosis and treatment indicators. The specialized care network was mapped according to State Health Secretaries Protocols. A threshold radius of 100 km was stablished as the maximum distance from municipalities centroids to specialised health care for children with microcephaly. Prenatal coverage was satisfactory in most of the study area, although availability of ultrasound equipment was uneven within states and health regions. Western Bahia had the lowest coverage of ultrasound equipment and lacked health rehabilitation services. ZCS's specialized health services were spread out over large areas, some of which were outside the affected patients' home municipalities, so displacements were expensive and very time consuming, representing an extra burden for the affected families. This study is the first to address accessibility of children with microcephaly to specialised health care services and points to the urgent need to expand coverage of these services in Brazil, especially in the northeastern states, which are most affected by the epidemic.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background: Autochthonous fruits such as Guavijú have beneficial health properties through their bioactive compounds and antioxidant capacity. This study aims to evaluate nutritional composition, ...phytochemical performance, total content of polyphenols, antioxidant capacity, and bioactive compounds of Guavijú (Eugenia pungens) fruits.
Methods: Macronutrients were analyzed using Anthrona method for carbohydrates, Kjeldahl method for proteins, and Soxhlet method for total fat. Phytochemical screening was performed to detect phenols, flavonoids, saponins, alkaloids, steroids and triterpenoids, as well as leukoanthocyanidins and quinones. The total content of polyphenols was obtained using Folin-Ciocalteu method. Antioxidant capacity was determined by ORAC method, and the identification of bioactive compounds was carried out through LC-QqQ MS/MS.
Results: Macronutrients were found in proportions of 33.4%, 5.5%, and 4.5% for carbohydrates, proteins, and fats, respectively. Phytochemical screening revealed the presence of phenols and triperthenoids. The total polyphenol content was 46.6 mg/g. Antioxidant capacity was 11394±705 μmol/100 g.
Conclusions: The identified bioactive compounds were cyanidin, delphinidin, enotein B, quercetin, and myricitrin. The results revealed that beneficial health properties due to the content of bioactive compounds and antioxidant capacity, which constitutes a food, can prevent diseases.
Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma worldwide. DLBCL is an aggressive disease that can be cured with upfront standard chemoimmunotherapy schedules. However, ...in approximately 35-40% of the patients DLBCL relapses, and therefore, especially in this setting, the search for new prognostic and predictive biomarkers is an urgent need. Natural killer (NK) are effector cells characterized by playing an important role in antitumor immunity due to their cytotoxic capacity and a subset of circulating NK that express CD8 have a higher cytotoxic function. In this substudy of the R2-GDP-GOTEL trial, we have evaluated blood CD8+ NK cells as a predictor of treatment response and survival in relapsed/refractory (R/R) DLBCL patients.
78 patients received the R2-GDP schedule in the phase II trial. Blood samples were analyzed by flow cytometry. Statistical analyses were carried out in order to identify the prognostic potential of CD8+ NKs at baseline in R/R DLBCL patients.
Our results showed that the number of circulating CD8+ NKs in R/R DLBCL patients were lower than in healthy donors, and it did not change during and after treatment. Nevertheless, the level of blood CD8+ NKs at baseline was associated with complete responses in patients with R/R DLBCL. In addition, we also demonstrated that CD8+ NKs levels have potential prognostic value in terms of overall survival in R/R DLBCL patients.
CD8+ NKs represent a new biomarker with prediction and prognosis potential to be considered in the clinical management of patients with R/R DLBCL.
https://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-001620-29 EudraCT, ID:2014-001620-29.
Indigenous plants such as the Tarumá tree may have beneficial health properties through their bioactive compounds and antioxidant capacity. The objective of this study was to evaluate the nutritional ...composition, the phytochemical performance, the total content of polyphenols, the antioxidant capacity and bioactive compounds of the fruits of the Tarumá tree (Vitex cymosa Berteo ex Speng) were evaluated for macronutrient content. Phytochemical screening was performed, the total content of polyphenols was obtained and the antioxidant capacity was determined. The macronutrients were in proportions of 11.3%, 9.3% and 16.4% for carbohydrates, proteins and fats respectively. Phytochemical screening showed the presence of phenols and triperthenoids. The total polyphenol content was 23 mg/g and the antioxidant capacity was (6773 ± 107) μmol/100 g. This study shows that the Tarumá fruits may have beneficial health properties based on the amount of polyphenols and antioxidant capacity thus making it likely to be able to prevent diseases caused by nutritional deficiencies.
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28.
Artritis reumatoide: una visión general Domínguez Freire, Nervo David; Alban Fierro, Pamela Elizabeth; Carvajal Santana, Gabriela Estefania ...
Revista cubana de reumatología,
08/2022, Volume:
24, Issue:
2
Journal Article
Peer reviewed
Open access
RESUMEN Introducción: Se han investigado y descrito numerosos tipos de artritis con el fin de clasificarlos en artritis no inflamatoria (osteoartritis) y artritis inflamatoria causada por cristales ...de depósito (seudogota, enfermedad del fosfato de calcio básico y gota), por bacterias e infecciones virales (Staphylococcus aureus, Neisseria gonorrohae, complicaciones de la enfermedad de Lyme, Parvovirus y Enterovirus) o por procesos autoinmunes. Objetivo: Presentar una visión global de la artritis reumatoide, con énfasis en el diagnóstico, fisiopatología y biomarcadores diagnósticos, pronósticos y predictivos en la artritis reumatoide, con el fin de contribuir la mejor atención de pacientes con enfermedades crónicas. Método: Se realizó una búsqueda bibliográfica relacionada con las palabras clave “artritis reumatoide” y otras variables de artritis. Se recuperaron 76 documentos que las incluían, de ellos utilizamos 42 que fueron útiles para el objetivo de la investigación. Conclusiones: El primer paso para un manejo efectivo de la enfermedad es un diagnóstico temprano y correcto, relacionado con que varios signos y síntomas también están asociados con otras enfermedades. Se debe incluir para este objetivo las estrategias de prevención de enfermedades, así como los programas de detección de personas en riesgo de desarrollarlas como el caso de la artritis reumatoide y la información de la enfermedad proporcionada a la población que pueden mejorar significativamente los parámetros epidemiológicos.
The effects of light spectra on cell concentration, cell size, biomass production, proximate composition, pigment content, and fatty acid content in
Chlorella vulgaris
during two growth phases were ...measured. Growth rates were higher with white (0.70 division day
−1
) and blue light (0.67 divisions day
−1
). Cell size was greater in the exponential growth with yellow light (16.29 μm) versus blue light (14.26 μm). Higher organic dry weight (ODW) values were observed during exponential growth under green light (70.58 pg cell
−1
) compared with white light (36.56 pg cell
−1
). Proximate composition differed significantly by effect of light spectra and growth phases. Protein content was significantly higher in the exponential growth with white light (34.42%) and green (31.64%) light. Carbohydrate levels were significantly higher during stationary growth under yellow light (27.05%). In the exponential growth, lipid content was significantly higher with blue light (18.74%). Biomass productivity was highest in exponential growth phase with blue light (0.064 gL
-1
day
-1
), meanwhile, in stationary growth phase yellow light (0.031 gL
-1
day
-1
). Chlorophyll a and carotenoid levels were significantly greater during exponential growth with green and yellow lights. Fatty acid content was significantly modified by the light spectra and growth phase. The predominant saturated fatty acid was C:16:0 (palmitic acid), ranging between 10.26 (green light and exponential growth) and 20.01% (white light and stationary growth). The content of C18:1n-9 was higher (28.34 %) with the white light in the stationary growth, and C18:3n-3 content was greater with white (41.41%) and blue light (40.82%) in the exponential growth. It was concluded that blue light is the most suitable condition to induce biomass productivity and lipid content on both growth phases. Blue light during the stationary growth phase induces the production of lipids and saturated fatty acids (SFAs) which are suitable for biodiesel production.
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