Summary Primary non-Hodgkin's lymphoma of the testicle is rare We analysed cases treated in French anticancer centres from 1969 to 1995 All cases were reviewed and classified according to the R E.A ...L. Classification. Eighty-four cases were included in this study The median age was 67 years (17–85) Disease was classified as stages I in 42 cases, stages II in 19 and stages III-IV in 23. Diffuse large B-cell lymphoma was diagnosed in 75% of cases. Treatment included orchidectomy and radiotherapy and/or chemotherapy. A complete response was obtained in 72 6% of the patient population and in 100%, 68% and 33% of stage I, II and III-IV disease respectively Recurrence occurred in 32 cases and the most frequent site was the central nervous system six of these patients presented stage I disease Median overall survival was 32 months for the entire population, 52 months for stage I. 32 months for stage II, and 12 months for stage III–IV cases (P < 0 0001) Among patients presenting stage I disease, no difference was found between those treated with combined surgery and chemotherapy or surgery followed or not followed by radiotherapy This study confirms that non-Hodgkin's lymphoma of the testicle carries a poor prognosis Systemic adjuvant chemotherapy should be discussed because of the high recurrence rate. Inclusion of these cases in large co-operative prospective studies is recommended
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Experimental data on the dielectric response of silica and hematite sols from the literature are interpreted using an analytical theory developed previously (Chassagne, C., Bedeaux, D., and Koper, G. ...J. M.,
J. Phys. Chem B
105, 11,743 (2001), and
Physica A, to be published). The theory is found to correctly predict both the relaxation frequency and the dielectric permittivity enhancement at low frequencies with only one free parameter. This parameter can be the zeta potential or the Stern layer conductance, in the case that the zeta potential is fixed to agree with the electrophoretic mobility measurements.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Using a method introduced by Albano et al. (Physica A 99 (1979) 293 and Physica A 102 (1980) 105) based on the concept of excess densities in the sense of Gibbs, and excess fluxes, an analytical ...expression for the frequency-dependent dipolar coefficient of a charged sphere in a electrolyte valid for all double layer thicknesses for low and high zeta potentials is derived. The found expression is compared to the analytical formulae of Fixman, Hinch et al. and O'Brien in their range of validity and to the numerical simulation of Mangelsdorf and White.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
We aimed to describe features and outcomes of cryptococcosis among HIV-seronegative individuals in a large surveillance network for cryptococcosis in France.
We included incident cases of ...cryptococcosis in HIV-seronegative individuals from 2005 to 2020. We compared patient characteristics, disease presentations, cryptococcal antigen results, and induction antifungal treatments according to underlying disease. We examined factors associated with 90-day mortality. Among patients with disseminated infections, we investigated whether receipt of flucytosine and polyene combination was associated with lower mortality.
Among 652 individuals, 209 (32.1%) had malignancy, 130 (19.9%) were solid-organ transplant recipients, 204 (31.3%) had other immunocompromising conditions, and 109 (16.7%) had no reported underlying factor. The commonest presentations were disseminated infections (63.3%, 413/652) and isolated pulmonary infections (25.3%, 165/652). Solid-organ transplant patients were most likely to have disseminated infections and a positive serum cryptococcal antigen result. Patients with malignancy were older and less likely to receive a flucytosine-containing regimen for disseminated infections than others (58.7%, 78/133 vs. 73.2%, 194/265; p 0.029). The crude 90-day case-fatality ratio was 27.2% (95% CI, 23.5%–31.1%). Age ≥60 years (aOR: 2.75 1.78–4.26; p < 0.001), meningitis/fungaemia (aOR: 4.79 1.80–12.7; p 0.002), and malignancy (aOR: 2.4 1.14–5.07; p 0.02) were associated with higher 90-day mortality. Receipt of flucytosine and polyene combination was associated with lower 90-day mortality (aOR: 0.40 0.23–0.71; p 0.002) in multivariable analysis and inverse probability of treatment weighted analysis (aOR: 0.45 0.25–0.80; p 0.006).
HIV-seronegative individuals with cryptococcosis comprise a wide range of underlying conditions with different presentations and outcomes, requiring a tailored approach to diagnosis and management.
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GEOZS, IJS, KILJ, NLZOH, NUK, PNG, SBCE, UILJ, UL, ZAGLJ
In a previous article (C. Chassagne, D. Bedeaux, G.J.M. Koper,
Physica A,
to be published) an analytical expression for the dipolar coefficient of a charged sphere in an electrolyte was derived as a ...function of the frequency which is valid for all double layer thicknesses both for low and for high zeta potentials. In order to access the whole range of zeta potentials an interpolation formula is derived and tested. It is concluded that for the systems for which experimental information is available the expression for high zeta-potentials is sufficient.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
An extension of the model for electrode polarization of Cirkel et al. Physica A 235 (1997) 269 is given. The problem is solved using both classical boundary conditions and the new boundary conditions ...using excess densities presented in a previous paper J. Phys. Chem. B 105 (2001) 11743. In the present paper, the electrodes are supposed to be ideal, meaning that charge transfer or adsorption are not considered. The advantage of the new boundary conditions lies in the possibility to extend to more complicated situations including for instance specific ion adsorption. We prove that the new boundary conditions and classical ones give the same results. A comparison of the model predictions, involving no adjustable parameters, experimental dielectric spectroscopy data is performed and fairly good agreement is found.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
We consider an asymmetric electrolyte between two cylindrical concentric electrodes that are uncharged in the absence of an applied voltage difference. We calculate the dielectric response of this ...capacitor to an alternating voltage difference. The problem is solved using both classical boundary conditions and the new boundary conditions using excess densities to describe the charge build-up near the condensator plates as given in a previous article (C. Chassagne, D. Bedeaux and G.J.M. Koper, Colloid Surf. A 210 (2002) 137.). We verify that both boundary conditions give the same results. The advantage of the new boundary conditions lies in the possibility to extend in the future the analysis to real electrodes including reactions and specific ion adsorption. A comparison of the model predictions, involving no adjustable parameters with experimental dielectric spectroscopy data, is performed and excellent agreement is found.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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