This study is the first one to explore the relation between career calling and employee voice and two potential mediators of this relationship, felt responsibility for constructive change and ...employee optimism about the future. Surveys from 406 employees of a law enforcement agency in the Midwest U.S. were analyzed using logistic regression and bootstrapping method with Structural Equation Modeling (SEM) to examine support for the hypotheses’ main and mediating effects. A behavioral measure was used to capture employees’ promotive voice behavior. Results indicated that individuals with stronger career calling were more likely to engage in promotive voice, after controlling for personality, perceptions toward work, and organizational tenure. In addition, career calling was positively associated with both felt responsibility and employee optimism. Finally, felt responsibility for constructive change fully mediated the relationship between career calling and promotive voice. The implications of these findings for researchers and practitioners are discussed.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
The current demand for patients’ organ and tissue repair and regeneration is continually increasing, where autologous or allograft is the golden standard treatment in the clinic. However, due to the ...shortage of donors, mismatched size and modality, functional loss of the donor region, possible immune rejection, and so forth, the application of auto‐/allo‐grafts is frequently hindered in many cases. In order to solve these problems, artificial constructs structurally and functionally imitating the extracellular matrix have been developed as substitutes to promoting cell attachment, proliferation, and differentiation, and ultimately forming functional tissues or organs for better tissue regeneration. Particularly, polymeric materials have been widely utilized in regenerative medicine because of their ease of manufacturing, flexibility, biocompatibility, as well as good mechanical, chemical, and thermal properties. This review presents a comprehensive overview of a variety of polymeric materials, their fabrication methods as well applications in regenerative medicine. Finally, we discussed the future challenges and perspectives in the development and clinical transformation of polymeric biomaterials.
With the evolution of the times, the definition of the essential nature of biological materials has undergone a fundamental change from biocompatibility to biomimicry, a process, which is still ongoing. Due to ease of manufacturing, flexibility, biocompatibility, as well as good mechanical, chemical, and thermal properties, polymeric biomaterials are widely applied in regenerative medicine, including bone, cardiovascular, skin, verve, biomedical devices, and so forth.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Purpose
The purpose of this paper is to study the role of task, relational and cognitive job crafting on the relationship between resiliency and meaningfulness in work.
Design/methodology/approach
...This study used path analysis under the framework of structural equation modeling to test the hypotheses using a sample of 374 law enforcement employees.
Findings
Results from the analysis revealed a direct effect of resiliency on meaningfulness. This study also found that relational and cognitive crafting partially mediate these relationships.
Practical implications
Understanding the proactive strategies resilient employees can use to build meaning in work will help managers develop better training programs. The findings emphasize the importance of building social relations and positive reframing of work as a mechanism to bounce back from adverse circumstances.
Originality/value
This paper provides empirical evidence of the proactive actions resilient employees implement to build meaningfulness in work.
Background
Vitamin D (VD) plays an important role in decreasing the risk of adverse events for various metabolic diseases. However, for patients with hyperlipidemia, the relationship between the main ...VD storage within the body known as serum 25-hydroxy-VD 25(OH)VD and the risk of all-cause, cardiovascular and malignancies-specific mortality is still unclear.
Materials and methods
A total of 6740 participants above the age of 20 years with hyperlipidemia who completed the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016 and were followed up until 2019 were included in the study. The weighted Cox proportional hazards regression model and weighted competing risk regression model were used to evaluate the risk for all-cause, cardiovascular and malignancy-related mortality in relation to the serum 25(OH)VD. The model was adjusted according to age, gender, race, body mass index, lipids status, medication usage, the Charlson comorbidity index and healthy eating index. The last restricted cubic spline (RCS) method was used to present the relationship between hazard ratios (HR) associated with diverse cause-specified modalities and the serum 25(OH)VD levels.
Results
Serum 25(OH)VD was identified as an independent factor for mortality. Lower serum 25(OH)VD under the threshold of 25.6 and 25.2 ng/ml were significantly associated with a higher risk for all-cause and cardiovascular mortalities, respectively. However, no association was found between malignancy-specific mortality and serum 25(OH)VD.
Conclusion
Serum 25(OH)VD were identified as an independent factor associated with risks of all-cause and cardiovascular mortalities in patient with hyperlipidemia. Moreover, lower serum 25(OH)VD than 25.6 and 25.2 ng/mL were, respectively, associated with a gradual increase in a risk for all-cause and cardiovascular mortality in patients with hyperlipidemia, and therefore regular monitoring of VD levels and correction of VD deficiency is recommended in those patients.
The emergence of high antimicrobial-resistant and hypervirulent Klebsiella pneumoniae (hvKp) clones in clinics has become a cause of concern in recent years. Despite the global spread of the clonal ...complex (CC) 258, hvKp of other non-CC258 subgroups also emerged. Here, by performing a retrospective study from July 2019 to August 2020 in a Chinese hospital, we obtained 25 K. pneumoniae isolates belonging to CC15. By antimicrobial susceptibility testing and whole genome sequencing and analysis, we obtained the resistant phenotypes and genotypes of these isolates. Twenty-one isolates (84%) were carbapenem-resistant, and eighteen were blaKPC-2 positive. In addition, ten isolates were identified as putative hvKp and seven were carbapenem-resistant hvKp. Nine isolates carried the pLVPK-like virulence plasmid, which contains the fragment including rmpA2, peg-589, iutA, and iucABCD. Another isolate carried iucA. Phylogenetic analysis revealed that the isolates belonged to four lineages, and the putative hvKp isolates were identified in three of these. Two independent sublineages of putative hvKp were caused by the acquisition of pLVPK-like virulence plasmid. Based on comparative genomic analysis, the number of pairwise single nucleotide polymorphisms amongst the four sublineages, Lineage 1a, 1b, 2a, and 2b, were 1–43, 2–13, 129–279, and 3–4, respectively, indicating clonal transmission of Lineage 1a, 1b, and 2b. These results indicate that multiple lineages of CC15 carbapenem-resistant hvKp have emerged in the hospital and caused nosocomial transmission, and that the spreading of virulence plasmids among classic K. pneumoniae subtypes might become more common and happen more easily. These findings highlight the importance of surveillance of local epidemics of non-CC258 subgroups in hospitals.
Everyday unnatural events such as trauma, accidents, military conflict, disasters, and even medical malpractice create open wounds and massive blood loss, which can be life-threatening. Fractures and ...large bone defects are among the most common types of injuries. Traditional treatment methods usually involve rapid hemostasis and wound closure, which are convenient and fast but may result in various complications such as nerve injury, deep infection, vascular injury, and deep hematomas. To address these complications, various studies have been conducted on new materials that can be degraded in the body and reduce inflammation and abscesses in the surgical area. This review presents the latest research progress in biomaterials for bone hemostasis and repair. The mechanisms of bone hemostasis and bone healing are first introduced and then principles for rational design of biomaterials are summarized. After providing representative examples of hemostatic biomaterials for bone repair, future challenges and opportunities in the field are proposed.
To accurately calculate the turbulent exchange coefficient, the contribution of multi-scale turbulent transportation needs to be considered, especially in the complex terrain of the coastal area. In ...September 2019, a comprehensive observation experiment on the offshore atmospheric boundary layer was carried out at the Yangmeikeng Ecological Monitoring Station and Sai Chung Gulf. Through scale decomposition, it is shown that the turbulent motion in the atmospheric boundary layer in the coastal area is affected by the underlying surface, such as that of the coastal land or the sea–land boundary. This is the main reason behind the phenomenon whereby different scales make different contributions to momentum flux. Different multi-scale characteristics of turbulent structures on the underlying surface affect the drag coefficient. Through wavelet transform and finite element method, the characteristics of the multi-scale flow structures produced by the complicated offshore terrain are analysed. It is found that large-scale flow structures enhance the pulsating intensity at the small scale, but the large-scale coherence characteristics are different from those at the small scale. In summary, in comparing these three sites, the flux exchange on the roof is greatest, followed by that on the tower. In the Gulf, the flux exchange is mainly dependent on small-scale structures, which are linked with the smallest values.
Although carbon-based single-atom catalysts (SACs), especially Fe–N–C, have been demonstrated as highly promising electrocatalysts for the oxygen reduction reaction (ORR) in alkaline media, their ...application remains a great challenge in acidic proton exchange membrane fuel cells (PEMFCs). Here, by performing high throughput first-principles calculations for 3d, 4d and 5d transition-metal single atoms immobilized on two-dimensional (2D) titanium carbide (Ti2CT and Ti3C2T) surfaces as active sites, we rationally design SACs towards a highly efficient ORR and further propose a composition descriptor to provide atomic-level insights into the structure–activity relationship. Significantly, the parameters involved in the present descriptor can be conveniently obtained from the periodic table of elements. More importantly, we found that the Ti2CO2-supported non-noble Cu SACs exhibit excellent ORR activity with much lower overpotential (0.25 V) than that of Pt/C (0.4 V), high selectivity for 4e oxygen reduction, excellent stability and acid-resistance and are quite promising ORR catalysts for PEMFCs. The present method can be extended to other 2D transition-metal carbides, i.e., MXenes.
•3D PCL/gelatin layered nanofiber sponge with uniformly grown Ag-MOF in situ and curcumin was fabricated.•The unique structure and antimicrobial nanomaterials enable it as wound ...dressing.•Long-lasting anti-infection effect and wound healing were demonstrated in mouse.
Effective hemostasis, antibacterial, and anti-inflammation are essential for wound healing, which, however, are hampered by the structural deficiencies of traditional wound dressings. Herein, we prepared a three-dimensional (3D) layered nanofiber sponge (3D-AgMOF-CUR), where silver-metal organic framework (Ag-MOF) was grown in situ and curcumin (CUR) was loaded, to promote the wound healing by timely absorbing exudate at the wound site, accelerating hemostasis, as well as resisting bacteria growth and inflammation. Nanostructure, water absorption capacity, porosity, elasticity and tensile properties, and drug release in vitro of the 3D-AgMOF-CUR were systemically characterized. Its outstanding hemostasis and coagulation effect were demonstrated by in vitro coagulation and blood suction tests. Experimental results from CCK-8 assay, disk diffusion and bacterial co-culture methods further evidenced the fantastic antibacterial effect and good cytocompatibility of the 3D-AgMOF-CUR. In addition, its high wound healing efficiency was confirmed in vivo, as revealed by improved wound healing efficiency and significantly decreased scar area during the healing process of a wound infection model. This study demonstrated that the layered 3D nanofiber sponge could shed light on the clinical wound healing in the future.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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•Various 3D printing techniques are discussed for creating bone repair scaffolds.•3D-printed scaffolds can accelerate the regeneration of bone defects.•3D-printed scaffolds can ...provide treatment strategies of bone infection.•3D-printed scaffolds can repair infected bone defects.•Perspectives for developing 3D-printed bone repair scaffolds are proposed.
The treatment of infected bone defects is a major clinical challenge, which requires the development of scaffolds to simultaneously eliminate infection and provide a suitable bioactive environment for bone growth. 3D printing offers a feasible solution to address this issue by producing patient-oriented bone tissue engineering scaffolds. Combined with clinical treatment protocols, 3D-printed products can shorten treatment time and maximize efficacy. In this review, various 3D printing techniques including stereolithography, two-photon polymerization, selective laser sintering, and extrusion-based printing were first introduced and representative examples of 3D-printed scaffolds for bone infection therapy and defect regeneration are provided. After discussing the treatment strategies against bone infection and strategies for bone repair, we propose design strategies of antibacterial and osteogenesis-active bifunctional scaffolds for the treatment of infected bone defects. Finally, current challenges in developing 3D printing techniques for bone tissue engineering scaffolds are summarized and future development directions for treating infected bone defects are proposed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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