Previous studies have suggested that strong safety climates (shared perceptions of safe conducts at work) are associated with lower workplace-injury rates, but they rarely control for differences in ...industry hazards. Based on 33 companies, we assessed its association with injury rates using three rate based injury measures (claims per 100 employees, claims per 100,000
h worked, and claims per US$ 1
million payroll), which were derived from workers’ compensation injury claims. Linear regression models were used to test the predictability of safety climate on injury rates, followed by controlling for differences in hazard across industries gauged by national industry-specific injury rates. In the unadjusted model, company level safety climate were negatively and significantly associated with injury rates. However, all of the above associations were no longer apparent when controlling for the hazardousness of the specific industry. These findings may be due to over adjustment of hazard risk, or the overwhelming effects of industry specific hazards relative to safety climate effects that could not be differentiated with the statistical power in our study. Industry differences in hazard, conceptualized as one type of injury risk, however need to be considered when testing the association between safety climate and injury across different industries.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
While most scholars have been attracted by the Qianlong emperor's history projects in asserting Manchu identity, few people have paid attention to the historical consciousness of the Manchus in the ...Manchu-language documents of the founding period. The Palace Historiographic Academy (Nei-guo-shi-yuan 內國史院), founded in 1636, was the earliest history office of the Qing Dynasty, and was responsible for keeping records, editing imperial pronouncements and producing historical documents. This paper will focus on the values and ethics that had been transmitted by these documents, thereby enabling us to assess more precisely the shaping of ‘Manchuness’ in the founding period of the Qing Dynasty.
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BFBNIB, NMLJ, NUK, PNG, UL, UM, UPUK
Straightforward deprotonation of soluble tetramethylammonium salts with alkyllithium reagents gives lithiomethyl trimethylammonium reagents. Coordination of the Li cation is crucial to the stability ...of these 'N-C ylides'. These reagents were used to prepare epoxides, aziridines and allylic alcohols.
Cyclopentadienone triisocyanide iron complexes were isolated and fully characterized for the first time. Two of the twelve isolated complexes could be crystallographically characterized.
...Irradiation of a toluene solution containing cyclopentadienone tricarbonyl iron complexes and isocyanides with blue LEDs afforded the formation and isolation of 12 triisocyanide complexes, two of which, namely tris(2,6-dimethylphenyl isocyanide)(η
4
-tetraphenylcyclopenatedienone)iron, Fe(C
9
H
9
N)
3
(C
29
H
20
O), and tris(naphthalen-2-yl isocyanide)(η
4
-tetraphenylcyclopenatedienone)iron acetone hemisolvate, Fe(C
11
H
7
N)
3
(C
29
H
20
O)
2
·C
3
H
6
O, could be characterized crystallographically. The air-stable compounds were purified by column chromatography and were characterized by
1
H NMR,
13
C NMR, elemental analysis and HRMS. NMR and XRD data indicate generally more electron-rich Fe
0
centers compared to the corresponding tricarbonyl compounds.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant repair that diminishes lung function via mechanisms that remain poorly understood. CC chemokine receptor (CCR10) and its ligand CCL28 ...were both elevated in IPF compared with normal donors. CCR10 was highly expressed by various cells from IPF lungs, most notably stage-specific embryonic antigen-4-positive mesenchymal progenitor cells (MPCs). In vitro, CCL28 promoted the proliferation of CCR10+ MPCs while CRISPR/Cas9-mediated targeting of CCR10 resulted in the death of MPCs. Following the intravenous injection of various cells from IPF lungs into immunodeficient (NOD/SCID-γ, NSG) mice, human CCR10+ cells initiated and maintained fibrosis in NSG mice. Eph receptor A3 (EphA3) was among the highest expressed receptor tyrosine kinases detected on IPF CCR10+ cells. Ifabotuzumab-targeted killing of EphA3+ cells significantly reduced the numbers of CCR10+ cells and ameliorated pulmonary fibrosis in humanized NSG mice. Thus, human CCR10+ cells promote pulmonary fibrosis, and EphA3 mAb-directed elimination of these cells inhibits lung fibrosis.
Diabetes has been reported to increase the risk of colorectal neoplasm in most but not all studies. However, the data on age- and sex-specific incidence rates and relative risks associated with ...diabetes are limited. We carried out this population-based cohort study to investigate the overall sex- and age-specific risks of colorectal cancer in association with diabetes. Diabetic patients (n = 615,532) and age- and sex-matched control individuals (n = 614,871), selected from the claim datasets, were followed up from 2000 to 2006. The rates of admission due to colon and rectum cancers were estimated using the person-years approach, and the age- and sex-specific hazard ratio (HR) for both the malignancies were determined using the Cox regression model. The overall incidence rate of colon cancer was 9.94 per 10,000 patient-years for the diabetic patients, as opposed to 7.84 per 10,000 patient-years for the control-group patients. The corresponding observation for rectal cancer was 7.16 and 6.28 per 10,000 patient-years. Diabetic patients aged ≥ 45 years had significantly high HRs for developing colon cancer (1.20-1.45-fold). We also noted a significantly high HR of rectal cancer in diabetic men (1.18-fold) aged ≥ 45 years, but not in diabetic women. In conclusion, diabetes may significantly increase the risk of colorectal cancer, especially in patients aged 45-64 years. Diabetologists should keep this relationship in mind while treating middle-aged diabetic men and should also advise these patients to undergo regular screening tests for colorectal cancer.
PAVING THE WAY FOR THE YEAR OF POLAR PREDICTION Goessling, Helge F.; Jung, Thomas; Klebe, Stefanie ...
Bulletin of the American Meteorological Society,
04/2016, Volume:
97, Issue:
4
Journal Article
Peer reviewed
Open access
...the impact of enhanced polar observations and predictions during YOPP on midlatitude predictions also needs to be assessed. ...all datasets should be published in data journals such as Earth ...System Science Data (ESSD), and a YOPP special issue in ESSD should be created.
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
To compare outcomes after accelerated partial breast irradiation (APBI) between node-negative and node-positive patients.
A total of 534 patients with early-stage breast cancer received APBI ...including 39 node-positive (N+) cases. Clinical, pathologic, and treatment-related factors were compared between node-negative (N-) and N+ cohorts. Local recurrence (LR), regional recurrence (RR), axillary failure (AF), distant metastases (DM), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS) were analyzed.
N+ patients were younger (p = 0.04), had larger tumors (p < 0.001), and were more likely to receive chemotherapy (p < 0.001). Mean follow-up was 7.8 years for N+ patients and 6.3 years for N- patients (p = 0.06). No differences were seen in 5-year actuarial rates of LR (2.2% vs. 2.6%, p = 0.86), AF (0% vs. 0%, p = 0.69), DFS (90.0% vs. 88.0%, p = 0.79), or OS (91.0 vs. 84.0%, p = 0.65) between the two groups, whereas higher rates of RR (0% vs. 6.1%, p < 0.001) and DM (2.2% vs. 8.9%, p = 0.005) were noted in N+ patients. A trend for improved CSS (p = 0.06), was seen in N- patients. Age, tumor size, receptor status, T-stage, chemotherapy, APBI technique, and nodal status (p = 0.86) were not associated with LR, while a trend for an association with LR was noted with close/positive margins, (p = 0.07), and failure to receive adjuvant hormonal therapy (p = 0.06).
No differences were seen in the rates of LR or AF between N- and N+ patients after APBI. These results support the continued enrollment of node-positive patients in Phase III trials evaluating the efficacy of APBI including the National Surgical Adjuvant Breast and Bowel Project-B39/Radiation Therapy Oncology Group 0413.
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GEOZS, IJS, NUK, OILJ, UL, UM, UPUK
Handling the (AFM) tip: The duration of stable molecular junctions was prolonged using a tactile feedback method in which the operator can sense the force of the AFM tip on the sample surface (see ...picture). The movement of the tip is adjusted accordingly, maintaining a more consistent current (i) and voltage (V), instead of having the tip move at a constant preset speed, as in the conventional setup.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
► We show that power series expansions can be used effectively in the pseudospectral solution of differential equations. ► We demonstrate that it is easy to implement this power series approach and ...computational cost could be reduced. ► As examples, results for wave propagation in complex optical systems are given. ► Procedures allowing one to use the real-time evolution method for finding stationary solutions are detailed.
The pseudospectral approach is a well-established method for studies of the wave propagation in various settings. In this paper, we report that the implementation of the pseudospectral approach can be simplified if power-series expansions are used. There is also an added advantage of an improved computational efficiency. We demonstrate how this approach can be implemented for two-dimensional (2D) models that may include material inhomogeneities. Physically relevant examples, taken from optics, are presented to show that, using collocations at Chebyshev points, the power-series approximation may give very accurate 2D soliton solutions of the nonlinear Schrödinger (NLS) equation. To find highly accurate numerical periodic solutions in models including periodic modulations of material parameters, a real-time evolution method (RTEM) is used. A variant of RTEM is applied to a system involving the copropagation of two pulses with different carrier frequencies, that cannot be easily solved by other existing methods.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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