In this paper, the electrical stability of organic thin‐film transistors (OTFTs) were investigated. Solution and photolithography technologies were used for organic thin film formation and ...patterning. All stacks were constructed with organic materials. However, the polymer‐type organic semiconductor material was used for active layer. Also, all process temperatures taken place below 120D. In addition, the OTFTs exhibit a good process uniformity and high stability. Furthermore, the OTFTs integrated with 6‐inch active matrix organic light emitting diodes (AMOLEDs) was realized.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Genome-wide search for the genes involved in arsenite resistance in two distinct variants A and A′ of
Leishmania amazonensis revealed that the two variants used two different mechanisms to achieve ...resistance, eventhough these two variants were derived from the same clone and selected against arsenite under the same conditions. In variant A, the variant with DNA amplification, the biochemical pathways for detoxification of oxidative stress, the energy generation system to support the biochemical and physiological needs of the variant for DNA and protein synthesis and the arsenite translocating system to dispose arsenite are among the primary biochemical events that are upregulated under the arsenite stress to gain resistance. In variant A′, the variant without DNA amplification, the upregulation of aquaglyceroporin (AQP) gene and the high level of resistance to arsenate point to the direction that the resistance gained by the variant is due to arsenate which is probably oxidized from arsenite in the arsenite solution used for selection and the maintenance of the cell culture. As a result of the AQP upregulation for arsenite disposal, a different set of biochemical pathways for detoxification of oxidative stress, energy generation and cellular signaling are upregulated to sustain the growth of the variant to gain resistance to arsenate. From current evidences, reactive oxygen species (ROS) overproduced by the parasite soon after exposure to arsenite appear to play an instrumental role in both variants to initiate the subsequent biochemical events that allow the same clone of
L. amazonensis to take two totally different routes to diverge into two different variants.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Because deep brain stimulation (DBS) implantations and other stereotactic and functional surgical procedures require accurate, precise, and safe targeting of the brain structure, the technical aids ...for preoperative planning, intervention, and postoperative follow-up have become increasingly important. In this paper, we introduce a case of advanced Parkinson′s disease with 10 years of medical control in which the patient received subthalamic nuclei (STN) DBS therapy through frameless surgery. A preliminary outcomes analysis is also provided. The STN DBS was implanted using a frameless stereotaxy protocol. After identifying the STN by microelectrode recording (MER), the DBS electrodes were implanted and connected to an implanted programmable generator. Programming started 1 month after the operation, and the patient was followed up on regularly and 12 months of post-STN DBS unified Parkinson′s disease rating scale were recorded. After 12 months of follow-up, the patient who received the frameless surgery showed a significant improvement in clinical motor functions compared with his preoperative scores. The frameless system has the advantage of providing accuracy in postoperative lead position survey and target deviation measurements with comparison to the preoperative planning image. The outcomes of frameless DBS surgery are similar to those of frame-based surgery, with the advantages being that frameless surgery can reduce the patient′s discomfort, shorten the operation and MER time, and decrease the MER trajectory number.
In this paper, a‐IGZO TFT fabricated with sputtered process and annealed with low temperature is investigated. For all the prcoess, the maximum process temperature is as low as 300°C In addition, a ...3.8 inch WVGA AM‐LCD driven by a‐IGZO TFTs is successfully demonstrated.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Objective
A recombinant annexin A5 with the N-terminal extension of six histidine residues was labeled with
99m
Tc(I)-tricarbonyl ion to produce the
99m
Tc-labeled annexin A5, referred to
99m
...Tc(I)-his
6
-annexin A5. We have explored the agent as an effective imaging probe for in vivo detecting the apoptosis of internal tissue subjected with high radiation doses in a γ-irradiated mouse model.
Methods
99m
Tc(CO)
3
(OH
2
)
3
+
was prepared and taken to directly label his
6
-annexin A5. The radiochemical purity of
99m
Tc(I)-his
6
-annexin A5 after size-exclusion separation was measured by HPLC. The binding affinity of
99m
Tc(I)-his
6
-annexin A5 to apoptotic cells was assessed using 20 Gy-irradiated Jurkat T cells. The effectiveness of
99m
Tc(I)-his
6
-annexin A5 as an imaging probe to detect the internal tissue apoptosis was assessed by biodistribution study and nanoSPECT/CT using the animal model of C57BL/6J mice conducted with 10 Gy γ irradiation.
Results
The radiochemical purity of
99m
Tc(I)-his
6
-annexin A5 could attain ≥95%. The binding affinity of
99m
Tc(I)-his
6
-annexin A5 to the 20 Gy-irradiated Jurkat cells was found to be ca. 20-fold higher than that to the sham-irradiated cells. In the animal imaging study, the splenic uptake of
99m
Tc(I)-his
6
-annexin A5 for the 10 Gy-irradiated mice showed from ca. 3-fold to 5-fold higher than those of the sham-irradiated mice from 45 to 165 min postinjection. The corresponding intestinal uptake showed from ca. 2-fold to 3-fold higher during the same period of time postinjection. The biodistribution study demonstrated the organ uptakes comparable with the imaging results. The apoptotic extents of the spleen and the intestine from the SPECT/CT imaging were correlated with an immunohistochemical staining assay for caspase 3 active form fragment.
Conclusion
This work is the first study to demonstrate that
99m
Tc(I)-his
6
-annexin A5 is a potential clinical imaging agent for detecting radiation-induced tissue apoptosis in an animal model.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
A 5.5 inches narrow bezel FFS‐mode De‐mux LCD was developed with the ESL type a‐IGZO TFTs. Those displays have de‐mux functions can narrow the bezel and reduce the number of ICs on the display. The ...Ion/Ioff of the ESL type TFTs are more than 109.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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