Inter-Satellite communication is one of remarkable technologies that can be used to communicate between satellites. This work is focused to carry out the investigations of polarization scheme by ...incorporating dense wavelength division multiplexing (DWDM) scheme in inter-satellite communication system. A 20×6 Gbps data are transported over inter-satellite optical link having span of 5,000 km to realize the total data transmission of 120 Gbps. Moreover, results are also reported with the effect of RZ and NRZ modulation schemes. The performance of proposed inter-satellite communication link is measured in terms of signal-to-noise ratio, received power and eye diagrams.
This work reports the magnetic phase transition in the polycrystalline La
0.90
Pr
0.10
Mn
0.8
Co
0.2
O
3
perovskite sample. The solid-state reaction was used for the synthesis of the polycrystalline ...sample. The detailed study of this polycrystalline sample includes the structural characterization by Rietveld refinement. The surface morphology by FESEM demonstrates a well-prepared sample. The EDAX spectra show the elemental confirmation in the prepared sample. For the detailed magnetic study, M–T and M–H measurements were performed by applying various external magnetic fields at various temperatures. The ZFC and FC curves have been measured under variable temperatures and they show the magnetic phase transition from ferromagnetic to paramagnetic. Also, the splitting between ZFC and FC curves depicts the relaxation mechanism in the sample. The scaling law suggests the orientation, strain effects, and domain structures. The FWHM of the peaks of both (ZFC & FC mode) is increasing with the applied field. This may be due to the magnetic relaxation in the sample. The M–H loops also confirm the ferromagnetic to a paramagnetism phase transition; however, the non-saturating appearance of M–H curves of all three systems is indicative of high magnetic anisotropy.
Dihydroorotate dehydrogenase (DHODH) is the key enzyme in de novo biosynthesis of pyrimidine in both prokaryotes and eukaryotes. The de novo pathway of pyrimidine biosynthesis is essential in cancer ...cells proliferation. Leflunomide is an approved DHODH inhibitor that has been widely used for the treatment of arthritis. Similarly, brequinar sodium is another DHODH inhibitor that showed anti-tumour effect in MC38 colon carcinoma cells when used in combination with fluorouracil. Despite the potential role of DHODH inhibitors in cancer therapy, their mechanisms of action remain obscure and await further elucidation. Here, we evaluated the effect of DHODH inhibitors on the production of ATP and ROS in sensitive and non-sensitive breast cancer cells. Subsequently, the effects of DHODH inhibitors on cell cycle as well as on signalling molecules such as p53, p65 and STAT6 were evaluated in sensitive T-47D and non-sensitive MDAMB-436 cells. The correlations between DHODH protein expression, proliferation speed and sensitivity to DHODH inhibitors were also investigated in a panel of cancer cell lines. DHODH inhibitors-sensitive T-47D and MDAMB-231 cells appeared to preserve ROS production closely to endogenous ROS level whereas the opposite was observed in non-sensitive MDAMB-436 and W3.006 cells. In addition, we observed approximately 90% of intracellular ATP depletion in highly sensitive T-47D and MDAMB-231 cells compared to non-sensitive MDAMB-436 cells. There was significant over-expression of p53, p65 and STAT6 signalling molecules in sensitive cells which may be involved in mediating the S-phase arrest in cell cycle progression. The current study suggests that DHODH inhibitors are most effective in cells that express high levels of DHODH enzyme. The inhibition of cell proliferation by these inhibitors appears to be accompanied by ROS production as well as ATP depletion. The increase in expression of signalling molecules observed may be due to pyrimidine depletion which subsequently leads to cell cycle arrest at S-phase.
•Evaluation of DHODH expression in cancer cells and their responds to DHODH inhibitors.•Cells expressing high DHODH showed high sensitivity to DHODH inhibitors.•Sensitive cells showed ATP depletion with no impact on ROS levels.•DHODH inhibitors upregulated the expression of p53, p65 and STAT6.•S-phase arrest was observed in cell lines sensitive to DHODH inhibitors.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Leclercia adecarboxylata, a Gram‐negative bacillus of family Enterobacteriaceae, is an uncommonly identified pathogen isolated from environmental and clinical specimens. Most of the human infections ...are polymicrobial and commonly occur in immunocompromised hosts, although nosocomial infections in immunocompetent hosts have been documented. Here, we describe the case of isolation of Leclercia species as polymicrobial infection from bovine suffering from respiratory distress in Chhattisgarh state of India. The isolates were identified by their phenotypes, 16S rDNA sequencing and MALDI‐TOF‐MS. The isolate was found to be resistant to aminoglycosides and fluoroquinolone antibiotics and intermediate resistant to cephalosporins and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard.
Significance and Impact of the Study
Leclercia adecarboxylata is a rarely reported human pathogen. We report here the case from bovine suffering from respiratory distress; the sample yielded Leclercia species as polymicrobial culture. The isolate was found to be multidrug resistant and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard. The limited literature available on this organism is reviewed, and the potential implications of findings are discussed. To the best of our knowledge, this is the first report of isolation and characterization of multidrug‐resistant Leclercia species from animal clinical case from India.
Significance and Impact of the Study: Leclercia adecarboxylata is a rarely reported human pathogen. We report here the case from bovine suffering from respiratory distress; the sample yielded Leclercia species as polymicrobial culture. The isolate was found to be multidrug resistant and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard. The limited literature available on this organism is reviewed, and the potential implications of findings are discussed. To the best of our knowledge, this is the first report of isolation and characterization of multidrug‐resistant Leclercia species from animal clinical case from India.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The objective of this paper is to give information about the optical and electrical characteristics measured of the CS–GO PNCs (chitosan-graphene oxide polymer nanocomposites), which is novel, ...biodegradable and biocompatible in nature. These nanocomposites have been synthesized by simple solution mixing technique trailed by ultrasonication treatment. The variation of GO nano-filler has shown a direct impact on the optical and electrical properties of the nanocomposite. According to the observations, optical absorption edge has a slightly shift towards the longer wavelength; while the optical band gap of the nanocomposite is constantly reduced on increasing the wt% of GO. In optical properties, the dielectric constant, dissipation factor and electrical conductivity have been found to increase with increasing wt% of GO in the PNC. Further, a shift in the relaxation frequency, at which dipole get relaxed indicating the interaction between the graphene and chitosan, has also been observed for different GO wt%. The conductivity of nanocomposites were increased to almost 10 times on increasing 2 wt% of GO. Taking into account the outcomes accomplished, the use of CS–GO PNC is reasonable for forthcoming advancement of optical sensors, and might be demonstrated as an expected possibility for the electrical or optoelectronic devices working at high frequencies.
Molecular dynamics simulations revealed significant difference in deformation behaviour of 〈1 0 0〉 BCC Fe nanowires with and without twist boundary. The plastic deformation in perfect 〈1 0 0〉 BCC Fe ...nanowire was dominated by twinning and reorientation to 〈1 1 0〉 followed by further deformation by slip mode. On the contrary, 〈1 0 0〉 BCC Fe nanowire with a twist boundary deformed by slip at low plastic strains followed by twinning at high strains and absence of full reorientation. The results suggest that the deformation in 〈1 0 0〉 BCC Fe nanowire by dislocation slip is preferred over twinning in the presence of initial dislocations or dislocation networks. The results also explain the absence of extensive twinning in bulk materials, which inherently contains large number of dislocations.
Full text
Available for:
BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The flow and work-hardening behaviour of tempered martensitic P92 steel have been investigated using phenomenological constitutive model in the temperature range 300-873 K for the strain rates ...ranging from 3.16 × 10
−5
to 1.26 × 10
−3
s
−1
. The analysis indicated that the hybrid model reduced to Estrin-Mecking (E-M) one-internal-variable model at intermediate and high temperatures. Further, the analysis also indicated that dislocation dense martensite lath/cell boundaries and precipitates together act as effective barriers to dislocation glide in P92 steel. The flow behaviour of the steel was adequately described by the E-M approach for the range of temperatures and strain rates examined. Three distinct temperature regimes have been obtained for the variations in work-hardening parameters with respect to temperature and strain rate. Signatures of dynamic strain ageing in terms of the anomalous variations in work-hardening parameters at intermediate temperatures and the dominance of dynamic recovery at high temperatures have been observed. The evaluation of activation energy suggested that deformation is controlled by the dominance of cross-slip of dislocations at room and intermediate temperatures, and climb of dislocations at high temperatures.
Full text
Available for:
BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
The model based on the coupled sine hyperbolic creep rate relation with the evolution of internal stress as a function of strain provides better understanding of primary and secondary creep behaviour ...of tempered martensitic 9Cr-1Mo steel. The predicted evolution of internal stress as an increase in the internal stress value (or, decrease in effective stress) with strain/time appropriately described the observed decrease in creep rate during primary creep in the steel. The applicability of the model has been demonstrated by comparing experimental and predicted creep strain-time and creep rate-strain/time data of 9Cr-1Mo steel at 793 and 873 K for quenched and tempered and simulated post-weld heat treatment conditions. Irrespective of prior heat treatment and test temperature, the optimised parameters associated with the internal stress values exhibited linear variations with applied stress. The influence of prior heat treatment on primary and secondary creep characteristics of the steel is reflected on the rate constant values associated with the model. At all temperatures and heat treatment conditions, good agreement between the experimental and predicted steady-state creep rates demonstrate the further applicability of the model.
Full text
Available for:
BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
Display omitted
•Graphene nanoribbon doped with Osmium (Os-ArGNRs) is reported for H2S sensing.•H2S shows strong interaction with Os doped ArGNRs at one-edge and both edges.•Adsorption energy of ...single & both–edge doping is −6.67 eV and −9.67 eV respectively.•Adsorption energies for Os-AGNR are 26 times and 38 times more than undoped ArGNR.•Both edge doped Os-AGNRs shows band gap change from semiconductor to metallic.
First Principles adsorption phenomenon of Hydrogen Sulfide (H2S) gas on surface of undoped armchair graphene nanoribbon (AGNRs) and Osmium doped AGNRs (Os-AGNRs) is reported. Adsorption energies and electronic properties of AGNRs doped with osmium atom in three possible configurations like one-edge doped, center doped and both-edge doped has been investigated theoretically using DFT. Results of adsorption energies revealed that undoped AGNR is insensitive to H2S gas with adsorption energy of about −0.25 eV. Whereas, osmium doped AGNRs at one-edge and both–edge doped position is having adsorption energies −6.67 eV and −9.67 eV, which is nearly 26 times and 38 times more than undoped AGNR. The both edges doped configuration shows significant variation in band gap after adsorption of gas. The study suggests that this novelboth edges doped Os-AGNRmaterial can be highly suitablefor H2S gas adsorption and sensing applications.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
