The MonALISA (Monitoring Agents in a Large Integrated Services Architecture) framework provides a set of distributed services for monitoring, control, management and global optimization for large ...scale distributed systems. It is based on an ensemble of autonomous, multi-threaded, agent-based subsystems which are registered as dynamic services. They can be automatically discovered and used by other services or clients. The distributed agents can collaborate and cooperate in performing a wide range of management, control and global optimization tasks using real time monitoring information.
Program title: MonALISA
Catalogue identifier: AEEZ_v1_0
Program summary URL:
http://cpc.cs.qub.ac.uk/summaries/AEEZ_v1_0.html
Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland
Licensing provisions: Caltech License – free for all non-commercial activities
No. of lines in distributed program, including test data, etc.: 147 802
No. of bytes in distributed program, including test data, etc.: 2 5913 689
Distribution format: tar.gz
Programming language: Java, additional APIs available in Java, C, C++, Perl and python
Computer: Computing Clusters, Network Devices, Storage Systems, Large scale data intensive applications
Operating system: The MonALISA service is mainly used in Linux, the MonALISA client runs on all major platforms (Windows, Linux, Solaris, MacOS).
Has the code been vectorized or parallelized?: It is a multithreaded application. It will efficiently use all the available processors.
RAM: for the MonALISA service the minimum required memory is 64 MB; if the JVM is started allocating more memory this will be used for internal caching. The MonALISA client requires typically 256–512 MB of memory.
Classification: 6.5
External routines: Requires Java: JRE or JDK to run. These external packages are used (they are included in the distribution): JINI, JFreeChart, PostgreSQL (optional).
Nature of problem: To monitor and control distributed computing clusters and grids, the network infrastructure, the storage systems, and the applications used on such facilities. The monitoring information gathered is used for developing the required higher level services, the components that provide decision support and some degree of automated decisions and for maintaining and optimizing workflow in large scale distributed systems.
Solution method: The MonALISA framework is designed as an ensemble of autonomous self-describing agent-based subsystems which are registered as dynamic services. These services are able to collaborate and cooperate in performing a wide range of distributed information-gathering and processing tasks.
Running time: MonALISA services are designed to run continuously to collect monitoring data and to trigger alarms or to take automatic actions in case it is necessary.
References:
1
http://monalisa.caltech.edu.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The combined effects of disinfectant agents on the microbiological quality of reclaimed water produced by two full-scale water reclamation plants in Catalonia, Spain, were examined in this work. All ...the disinfectant treatments tested led to the absence, or near absence, of E. coli in 100 mL samples of water, with log reductions of more than 3 log u. Hypochlorite reduced the bacterial concentrations. However, ultraviolet light was more effective than hypochlorite at reducing the concentrations of bacteriophages, viruses and pathogenic protozoa such as Cryptosporidium spp. We conclude that a combination of these two disinfectant agents is effective in protecting public health, as each agent acts to a different degree against the different groups of microorganisms studied. Further studies should investigate the combined action of disinfectant agents at water reclamation plants with ultraviolet light equipment in more favourable working conditions in order to assess their capacity to inactivate microorganisms.
We present a new method for solving the fixed point equations that appear in the static analysis of programs by abstract interpretation. We introduce and analyze a policy iteration algorithm for ...monotone self-maps of complete lattices. We apply this algorithm to the particular case of lattices arising in the interval abstraction of values of variables. We demonstrate the improvements in terms of speed and precision over existing techniques based on Kleene iteration, including traditional widening/narrowing acceleration mecanisms.
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FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Update information regarding occurrence and levels of culturable enteroviruses in several types of surface polluted waters in north-eastern Spain and determine the proportion of the different species ...and serotypes. The best procedures on hand in our laboratory for concentrating and quantifying culturable enteroviruses from different water sample types were used. Sequencing was used for typing the virus isolates. Geometric means of enteroviruses densities expressed in plaque forming units per litre were 968 in raw sewage, 12·51 in secondary effluents, 0·017 in tertiary effluents, 0·4 in river water and 0·36 in seawater. Enterovirus densities in wastewater revealed certain seasonality with a maximum at the end of spring - beginning of the summer. Coxsackievirus B, and amid them serotype CB4, were the most abundant species and serotypes detected. Densities of enteroviruses in different north-eastern Spain surface waters are similar to those present in industrialized countries with temperate climate. No wild polioviruses were detected. Distribution of species showed a clear prevalence of coxsackieviruses. Information regarding enteroviruses in this geographical area provides valuable information to estimate the risk of enteroviruses transmission through water and for complementing clinical epidemiological data.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Bacterial synthetic multicellular systems are promising platforms for engineered living materials (ELMs) for medical, biosynthesis, environmental, and smart materials applications. Recent ...advancements in genetically encoded adhesion toolkits have enabled precise manipulation of cell-cell adhesion and the design and patterning of self-assembled multicellular materials. However, in contrast to gene regulation in synthetic biology, the characterization and control of synthetic adhesins remains limited. Here, we demonstrate the quantitative characterization of a bacterial synthetic adhesion toolbox through various biophysical methods. We determine key parameters, including number of adhesins per cell, in-membrane diffusion constant, production and decay rates, and bond-breaking force between adhesins. With these parameters, we demonstrate the bottom-up prediction and quantitative tuning of macroscopic ELM properties (tensile strength) and, furthermore, that cells inside ELMs are connected only by a small fraction of available adhesins. These results enable the rational engineering, characterization, and modeling of other synthetic and natural adhesins and multicellular consortia.
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•Synthetic bacterial systems hold promise for medical and smart biomaterials•The study demonstrates quantitative characterization of a synthetic adhesion toolbox•Macroscopic material properties can be tuned and predicted through a bottom-up approach
Synthetic multicellular systems provide versatile building blocks for engineered living materials (ELMs). Precise control of cell-cell adhesion is crucial for multicellular material engineering, especially with synthetic adhesion tools becoming available recently. Here, we demonstrate a general framework for quantitatively characterizing the key biophysical parameters of such an adhesion toolbox. We then demonstrate how these parameters allow the prediction and tuning of macroscopic bacteria-based ELM properties such as tensile strength. These results have direct relevance for bioprinting, where the ideal bioink should possess well-defined mechanical and biological characteristics. More broadly, this work bridges synthetic biology and material science and introduces mathematical prediction and rational tuning of ELM properties for aiding quantitative, model-supported ELM development.
To expand the integration of synthetic biology in material science, we quantitatively characterized a bacterial synthetic adhesion toolbox through several biophysical methods. Specifically, we measured the synthetic adhesins’ turnover rates, their surface density and spatial distribution, their membrane diffusion rate, and their intermolecular bond-breaking force. With these parameters, we then demonstrated how to predict and quantitatively tune the macroscopic properties of engineered living materials consisting of cells expressing these synthetic adhesins, which is essential for applications such as bioprinting.
Background: In older adults, a serum 25-hydroxyvitamin D 25(OH)D concentration >75 nmol/L lowers the risk of fracture. An oral intake of 125 mu g (5000 IU) vitamin D sub(3)/d may be required to ...achieve this target. Objective: The objective was to characterize the safety and efficacy of fortifying bread with a biologically meaningful amount of vitamin D sub(3). Design: In a single-arm design, 45 nursing home residents consumed one bun daily that had been fortified with 125 mu g (5000 IU) vitamin D sub(3) and 320 mg elemental calcium. Results: The initial mean ( plus or minus SD) serum 25(OH)D concentration was 28.5 plus or minus 10.8 nmol/L. After 12 mo, the 25(OH)D concentration was 125.6 plus or minus 38.8 nmol/L, and it exceeded 74 nmol/L in 92% of the patients. At every 3-mo follow-up, serum parathyroid hormone was lower than at baseline (P = 0.001). No changes in serum calcium or cases of hypercalcemia were observed at the follow-up assessments. Both mean total urinary calcium and the mean urinary calcium-creatinine ratio increased from baseline at one follow-up time point (P < 0.05). Between baseline and the 12-mo visit, z scores for bone mineral density at the lumbar spine and the hip both increased significantly (P < 0.001). Conclusions: Fortification of bread with much more vitamin D than used previously produced no evident adverse effects on sun-deprived nursing home residents and improved bone density measures. Fortification of bread with 5000 IU vitamin D sub(3)/d provided reasonable assurance that vitamin D-deficient older adults attained a serum 25(OH)D concentration greater than the desirable objective of >75 nmol/L.
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CMK, GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Introspection is the prerequisite of autonomic behavior, the first step towards performance improvement and resource usage optimization for large-scale distributed systems. In grid environments, the ...task of observing the application behavior is assigned to monitoring systems. However, most of them are designed to provide general resource information and do not consider specific information for higher-level services. More precisely, in the context of data-intensive applications, a specific introspection layer is required to collect data about the usage of storage resources, data access patterns, etc. This paper discusses the requirements for an introspection layer in a data management system for large-scale distributed infrastructures. We focus on the case of BlobSeer, a large-scale distributed system for storing massive data. The paper explains why and how to enhance BlobSeer with introspective capabilities and proposes a three-layered architecture relying on the MonALISA monitoring framework. We illustrate the autonomic behavior of BlobSeer with a self-configuration component aiming to provide storage elasticity by dynamically scaling the number of data providers. Then we propose a preliminary approach for enabling self-protection for the BlobSeer system, through a malicious client detection component. The introspective architecture has been evaluated on the Grid'5000 testbed, with experiments that prove the feasibility of generating relevant information related to the state and behavior of the system.
The feasibility of detecting somatic coliphages by phage infection of
Escherichia coli WG5 and measurement of phage propagation by the lysis mediated release of the bacterial host adenylate kinase ...(AK) and adenosine 5′-triphosphate (ATP) detected by a bioluminescent signal was evaluated. After 2
h of incubation, all cultures infected with reference bacteriophage ϕX174 showed a significant increase in the bioluminescent signal, even with number of phages as low as less of 10 plaque forming units (PFU). Naturally occurring somatic coliphages ensured a significant bioluminescent signal after 3
h of infection when >10 PFU were inoculated. These results indicate that an easy and reliable method to detect low numbers of coliphages in less than 3
h is feasible.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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