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  • Extensive innate immune gen... Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
    Cribbs, David H; Berchtold, Nicole C; Perreau, Victoria ... Journal of neuroinflammation, 07/2012, Volume: 9, Issue: 1
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    Peer reviewed
    Open access

    This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer's disease (AD). In a well-powered ...
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  • Activation of Ras-ERK Signa... Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease
    Kirouac, Lisa; Rajic, Alexander J; Cribbs, David H ... eNeuro, 03/2017, Volume: 4, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    It is widely accepted that amyloid β (Aβ) generated from amyloid precursor protein (APP) oligomerizes and fibrillizes to form neuritic plaques in Alzheimer's disease (AD), yet little is known about ...
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  • Gene expression changes in ... Gene expression changes in the course of normal brain aging are sexually dimorphic
    Berchtold, Nicole C; Cribbs, David H; Coleman, Paul D ... Proceedings of the National Academy of Sciences, 10/2008, Volume: 105, Issue: 40
    Journal Article
    Peer reviewed
    Open access

    Gene expression profiles were assessed in the hippocampus, entorhinal cortex, superior-frontal gyrus, and postcentral gyrus across the lifespan of 55 cognitively intact individuals aged 20-99 years. ...
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  • Synaptic genes are extensiv... Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease
    Berchtold, Nicole C; Coleman, Paul D; Cribbs, David H ... Neurobiology of aging, 06/2013, Volume: 34, Issue: 6
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    Open access

    Abstract Synapses are essential for transmitting, processing, and storing information, all of which decline in aging and Alzheimer's disease (AD). Because synapse loss only partially accounts for the ...
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  • Biologic TNF-α inhibitors r... Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy
    Ou, Weijun; Yang, Joshua; Simanauskaite, Juste ... Journal of neuroinflammation, 12/2021, Volume: 18, Issue: 1
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    Open access

    Tumor necrosis factor-α (TNF-α) plays a central role in Alzheimer's disease (AD) pathology, making biologic TNF-α inhibitors (TNFIs), including etanercept, viable therapeutics for AD. The protective ...
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  • Blocking IL-1 signaling res... Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model
    Kitazawa, Masashi; Cheng, David; Tsukamoto, Michelle R ... The Journal of immunology (1950), 2011-Dec-15, 2011-12-15, 20111215, Volume: 187, Issue: 12
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    Inflammation is a key pathological hallmark of Alzheimer's disease (AD), although its impact on disease progression and neurodegeneration remains an area of active investigation. Among numerous ...
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  • Novel Vaccine against Patho... Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer's Disease
    Zagorski, Karen; King, Olga; Hovakimyan, Armine ... International journal of molecular sciences, 06/2023, Volume: 24, Issue: 12
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    Open access

    Post-translationally modified N-terminally truncated amyloid beta peptide with a cyclized form of glutamate at position 3 (pE Aβ) is a highly pathogenic molecule with increased neurotoxicity and ...
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  • Aspirin-Triggered Lipoxin A... Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice
    Medeiros, Rodrigo; Kitazawa, Masashi; Passos, Giselle F ... The American journal of pathology, 05/2013, Volume: 182, Issue: 5
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    Microglia play an essential role in innate immunity, homeostasis, and neurotropic support in the central nervous system. In Alzheimer disease (AD), these cells may affect disease progression by ...
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  • Semi-automated protocol to ... Semi-automated protocol to quantify and characterize fluorescent three-dimensional vascular images
    Xie, Danny F; Crouzet, Christian; LoPresti, Krystal ... PloS one, 05/2024, Volume: 19, Issue: 5
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    Open access

    The microvasculature facilitates gas exchange, provides nutrients to cells, and regulates blood flow in response to stimuli. Vascular abnormalities are an indicator of pathology for various ...
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  • Amyloid-β peptide binds to ... Amyloid-β peptide binds to cytochrome C oxidase subunit 1
    Hernandez-Zimbron, Luis Fernando; Luna-Muñoz, Jose; Mena, Raul ... PloS one, 08/2012, Volume: 7, Issue: 8
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    Open access

    Extracellular and intraneuronal accumulation of amyloid-beta aggregates has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). However, the precise mechanism of ...
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