Abstract Objective A meta-analysis was performed on epidemiologic studies to assess the relation between β-glucan consumption from oats and from barley on blood cholesterol level, ...triglyceride/triacylglycerol (TGL/TAG) level, and blood glucose level (BGL) in humans. In addition, the effect of β-glucan on total cholesterol (TC) and BGL was translated into an empirical dose–response model. Methods Thirty research articles that evaluated the effect of different exposure levels of β-glucan on blood cholesterol and BGL were analyzed, yielding 126 clinical studies. Results There was a significant inverse relation in TC (−0.60 mmol/L, 95% confidence interval CI −0.85 to −0.34), low-density lipoprotein (−0.66 mmol/L, 95% CI −0.96 to −0.36), and TGL/TAG (−0.04 mmol/L, 95% CI −0.15 to 0.07) after consumption of β-glucan. In contrast, an increase in high-density lipoprotein cholesterol was noted (0.03 mmol/L, 95% CI −0.06 to 0.13) with the random-effect model. The analysis showed a significant change in BGL (−2.58 mmol/L, 95% CI −3.22 to −1.84) with high heterogeneity between ( I2 = 97%) and across (τ2 = 5.88) the studies. The fixed-effect model showed a significant change in TC, low-density lipoprotein, and BGL, whereas it showed no significant changes in high-density lipoprotein and TGL/TAG. The dose–response model showed that a 3-g/d dose of oat or barley β-glucan was sufficient to decrease TC. Conclusion Consumption of 3 g/d of oat or barley β-glucan is sufficient to decrease blood cholesterol, whereas the effect on BGL is still inconclusive, with high heterogeneity, and requires further clinical research studies with longer intervention periods.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Antibiotic-resistant bacteria (ARB) have gained increased notoriety due to their continued detection in environmental media and consequently their threat to human and animal health. The continuing ...spread of antibiotic resistance throughout the environment is of growing environmental and public health concern, making it difficult to treat harmful resistant diseases. This paper examines the presence of antibiotics, ARB, and antibiotic-resistant genes (ARGs) in aquatic environments; the effectiveness of current water treatment strategies to remove them; and risk assessment methods available that can be used to evaluate the risk from antibiotic resistance. Antibiotics, ARB, and ARGs have been reported at varying levels in wastewater treatment plants, hospital wastewater, irrigation water, recreational water, and drinking water. There are many different water treatments capable of reducing antibiotic resistance (including chlorination, UV, and ozone); however, no one method can fully eliminate it with much variation in the reported effects. Risk assessment models can be used for interpreting field data into the risk to human health from antibiotic resistance. Currently, there is no gold standard risk assessment method for evaluating antibiotic resistance. Methods in this area need further development to reflect evolving risk assessment methodologies and dynamic data as it emerges.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
Antimicrobial resistance is a major concern for human and animal health, projected to deteriorate with time and given current trends of antimicrobial usage. Antimicrobial use, particularly in ...healthcare and agriculture, can result in the release of antimicrobials into surface waters, promoting the development of antibiotic resistance in the environment, and potentially leading to human health risks. This study reviews relevant literature, and investigates current European and Irish antimicrobial usage trends in humans and animals, as well as potential pathways that antibiotics can take into surface waters following use. Reported levels in the aquatic environment are summarized, with particular focus on Ireland. There are relatively few studies examining Irish water bodies or sewage effluent for antibiotic residues, however, five antibiotics, namely azithromycin, ciprofloxacin, clarithromycin, metronidazole, and trimethoprim, have been measured in Irish waters, in concentrations predicted to select for resistance. Numerous isolates of multi-drug resistant bacteria have also been found in water bodies throughout Ireland and Europe. The value of risk assessment methodologies in understanding risks posed by antibiotic residues is reviewed including the advantages and disadvantages of specific approaches. Hazard quotient and bespoke Monte Carlo approaches are predominant risk assessment tools used to examine antimicrobial release and their complex pathways. This study highlights the need for monitoring of antimicrobial releases and the potential for resistance development, persistence and transmission while highlighting the role of risk assessment methodologies in assessing potential human and environmental health impacts.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
As process-based environmental fate and transport models for engineered nanoparticles are developed, there is a need for relevant and reliable measures of nanoparticle behavior. The affinity of ...nanoparticles for various surfaces (α) is one such measure. Measurements of the affinity of nanoparticles obtained by flowing particles through a porous medium are constrained by the types of materials or exposure scenarios that can be configured into such column studies. Utilizing glass beads and kaolinite as model collector surfaces, we evaluate a previously developed mixing method for measuring nanoparticle attachment to environmental surfaces, and validate this method with an equivalent static column system over a range of organic matter concentrations and ionic strengths. We found that, while both impacted heteroaggregation rates in a predictable manner when varied individually, neither dominated when both parameters were varied. The theory behind observed nanoparticle heteroaggregation rates (αβB) to background particles in mixed systems is also experimentally validated, demonstrating both collision frequency (β) and background particle concentration (B) to be independent for use in fate modeling. We further examined the effects of collector particle composition (kaolinite vs glass beads) and nanoparticle surface chemistry (PVP, citrate, or humic acid) on α, and found a strong dependence on both.
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IJS, KILJ, NUK, PNG, UL, UM
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•Probabilistic risk assessment of NBPT based on a farm to fork approach was developed.•Human health risk assessment of NBPT will reduce the gap in literature.•Mean EDI of NBPT ...(5 × 10−11 mg NBPT/kg body weight/day) is below the ADI.•NBPT exposure assessment analysis reveals low risk to human health.
The urease inhibitor N-(n-butyl) thiophosphoric triamide (NBPT) has recently attracted a lot of attention attributing to its efficiency in reducing ammonia loss from urea fertiliser applied to temperate grassland soils. Ammonia gas lost to the environment causes soil acidification, eutrophication and contributes to global warming through increased greenhouse gas emissions and ozone layer depletion. The active chemical NBPT blocks the soil microbial enzyme (urease) and reduces ammonia emission. Furthermore, NBPT’s use in agriculture might benefit farmers by reducing reliance on expensive nitrate fertiliser and aiding in a shift to more urea-based fertiliser (using NBPT co-applied with urea is more cost-effective). The present study was carried out to characterise the potential transfer of NBPT from grass to liquid milk and compute the associated human health risks. Using probabilistic risk assessment techniques, an exposure assessment model was developed to calculate the Estimated Daily Intake (EDI) of NBPT from milk, following co-application of NBPT with a urea N-fertiliser. Results show that the predicted mean concentration of NBPT in milk is 2.5 × 10−8 mg NBPT/kg milk, while the mean daily intake (EDI) of NBPT is 5 × 10−11 mg NBPT /kg BW/day). Back-calculations revealed that, under the studied conditions, for the EDI to exceed ADI of 3 × 10−2 mg NBPT/kg BW/ day, the NBPT application rate would need to exceed the NBPT fertiliser limit (0.09–0.2% by mass of urea nitrogen) set in the Commission Regulation (EC) No 1107/2008, and the bio-transfer factor would need to be over 100% (implausible). Sensitivity analysis revealed soil pH (SPH), phytoaccumulation factor (PF), NBPT permissible levels in fertiliser (NBPT%), pasture cover (P), and grazing rotation length (t) as critical factors influencing the EDI of NBPT. The present study concludes that NBPT presents negligible risk to human health under the conditions and assumptions studied.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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•COVID-19 pandemic is clearly challenging the entire food system.•A collective action is needed in order to build food systems that are resilient.•Food systems are multidisciplinary ...and highly interconnected.•Food security is important in times of shocks and crises.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Marine plastic waste pollution is one of the most urgent global marine environmental problems worldwide. It has attracted worldwide attention from governments, the public, the scientific community, ...media and non-governmental organizations and has become a hot issue in current marine ecology and environmental research. This research aimed to conduct a traditional review of the current state of the art regarding microplastics (MPs) definition and characterisation, including an assessment of MPs detected in marine and food systems. The review revealed that plastic waste is not biodegraded and can only be broken down, predominantly by physical processes, into small particles of micron to nanometre size. Particles (<150 μm) can be ingested by living organisms, migrate through the intestinal wall and reach lymph nodes and other body organs. The primary pathway of human exposure to MPs has been identified as gastrointestinal ingestion (mainly seafood for the general population), pulmonary inhalation, and dermal infiltration. MPs may pollute drinking water, accumulate in the food chain, and release toxic chemicals that may cause disease, including certain cancers. Micro/nano-plastics may pose acute toxicity, (sub) chronic toxicity, carcinogenicity, genotoxicity, and developmental toxicity. In addition, nanoplastics (NPs) may pose chronic toxicity (cardiovascular toxicity, hepatotoxicity, and neurotoxicity). The toxicity of MPs/NPs primarily depends on the particle size distribution and monomeric composition/characteristics of polymers. Polyurethane (PUR), Polyacrylonitrile (PAN), Polyvinyl chloride (PVC), Epoxy resin, and Acrylonitrile-butadiene-styrene (ABS) are categorised as the most toxic polymers based on monomer toxicity. MP detection methods include combinations of spectroscopic analysis (RS and FTIR) and chromatography (TED-GC/MS). MP/NP toxicological properties and general quantitative and qualitative analysis methods used in MPs Risk Assessment (RA) are summarised. A robust dose-response model for MPs/NPs requires further investigation. This study lays the foundation for the evaluation of MP/NP risk assessment in the marine ecosystem and potential implications for human health.
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•Small plastic particles (<150 μm) can be absorbed by biota tissue, organs, and even cells.•Microplastics may pose acute and (sub) chronic toxicity, carcinogenicity, and developmental toxicity.•Similarly, nanoplastics may pose chronic toxicity, genotoxicity, and developmental toxicity.•PUR, PAN, PVC, Epoxy resin, and ABS are identified as the most toxic polymers.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Each year in Europe, meat is associated with 2.3 million foodborne illnesses, with a high contribution from beef meat. Many of these illnesses are attributed to pathogenic bacterial contamination and ...inadequate operations leading to growth and/or insufficient inactivation occurring along the whole farm-to-fork chain. To ensure consumer health, decision-making processes in food safety rely on Quantitative Microbiological Risk Assessment (QMRA) with many applications in recent decades. The present study aims to conduct a critical analysis of beef QMRAs and to identify future challenges. A systematic approach, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was used to collate beef QMRA models, identify steps of the farm-to-fork chain considered, and analyze inputs and outputs included as well as modelling methods. A total of 2343 articles were collected and 67 were selected. These studies focused mainly on western countries and considered
(EHEC) and
spp. pathogens. Future challenges were identified and included the need of whole-chain assessments, centralization of data collection processes, and improvement of model interoperability through harmonization. The present analysis can serve as a source of data and information to inform QMRA framework for beef meat and will help the scientific community and food safety authorities to identify specific monitoring and research needs.
Nanomaterials are finding application in many different environmentally relevant products and processes due to enhanced catalytic, antimicrobial, and oxidative properties of materials at this scale. ...As the market share of nano‐functionalized products increases, so too does the potential for environmental exposure and contamination. This study presents some exposure ranking methods that consider potential metallic nanomaterial surface water exposure and fate, due to nano‐functionalized products, through a number of exposure pathways. These methods take into account the limited and disparate data currently available for metallic nanomaterials and apply variability and uncertainty principles, together with qualitative risk assessment principles, to develop a scientific ranking. Three exposure scenarios with three different nanomaterials were considered to demonstrate these assessment methods: photo‐catalytic exterior paint (nano‐scale TiO2), antimicrobial food packaging (nano‐scale Ag), and particulate‐reducing diesel fuel additives (nano‐scale CeO2). Data and hypotheses from literature relating to metallic nanomaterial aquatic behavior (including the behavior of materials that may relate to nanomaterials in aquatic environments, e.g., metals, pesticides, surfactants) were used together with commercial nanomaterial characteristics and Irish natural aquatic environment characteristics to rank the potential concentrations, transport, and persistence behaviors within subjective categories. These methods, and the applied scenarios, reveal where data critical to estimating exposure and risk are lacking. As research into the behavior of metallic nanomaterials in different environments emerges, the influence of material and environmental characteristics on nanomaterial behavior within these exposure‐ and risk‐ranking methods may be redefined on a quantitative basis.
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BFBNIB, FSPLJ, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Bisphenol A (BPA) is a commonly used compound in many industries and has versatile applications in polycarbonate plastics and epoxy resins production. BPA is classified as endocrine-disrupting ...chemical which can hamper fetal development during pregnancy and may have long term negative health outcomes in humans. Dietary sources, main route of BPA exposure, can be contaminated by the migration of BPA into food during processing. The global regulatory framework for using this compound in food contact materials is currently not harmonized. This review aims to outline, survey, and critically evaluate BPA contamination in meat products, including level of BPA and/or metabolites present, exposure route, and recent advancements in the analytical procedures of these compounds from meat and meat products. The contribution of meat and meat products to the total dietary exposure of BPA ranges between 10 and 50% depending on the country and exposure scenario considered. From can lining materials of meat products, BPA migrates towards the solid phase resulting higher BPA concentration in solid phase than the liquid phase of the same can. The analytical procedure is comprised of meat sample pre-treatment, followed by cleaning with solid phase extraction (SPE), and chromatographic analysis. Considering several potential sources of BPA in industrial and home culinary practices, BPA can also accumulate in non-canned or raw meat products. Very few scientific studies have been conducted to identify the amount in raw meat products. Similarly, analysis of metabolites and identification of the origin of BPA contamination in meat products is still a challenge to overcome.
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