Abstract
We present a timing study of the short-period eclipsing cataclysmic variable (CV) HT Cas. Based on new eclipse times derived from our photometric monitoring and archival optical data, ...combined with historical timings, spanning ∼42 yr, we detect a secular decrease in the orbital period at a rate of
P
̇
=
−
1.32
×
10
−
12
ss
−
1
and a cyclic period wiggle with an amplitude of 79.3 s and a period of 30.28 yr. We find that neither gravitational radiation nor magnetic braking can explain the observed decrease rate, suggesting the presence of additional angular momentum loss (AML). The empirical consequential AML (eCAML) model developed by Schreiber et al. can well match the observed orbital decay in HT Cas, and the physical mechanism for eCAML is most likely attributable to the frictional AML following nova eruptions. As for the cyclic variation, the best explanation is the influence of an unseen companion in orbit around the binary. The derived orbital parameters reveal that the hypothetical third body could be a giant planet with mass of
M
3
≃ 14
M
Jup
that is moving on a highly eccentric orbit (
e
= 0.82). Taken together the results of the present study suggest that HT Cas is a unique triple system containing a high-eccentricity giant planet and it has the potential to become an ideal laboratory in which to test models of CV evolution.
Background
Crohn's disease (CD) is frequently associated with malnutrition, inflammation and a deficiency of vitamin D (VD) with the relationships between these symptoms being poorly defined. VD is a ...modulator of the immune system and is associated with the onset of CD and disease activity. The level of serum VD may have potential in the assessment of CD activity. This study aimed to evaluate the relationships between VD, nutritional status and inflammation, and to identify more accurate VD thresholds.
Methods
The study included 76 outpatients with CD diagnosed between October 2018 and October 2020 and 76 healthy volunteers. Levels of serum 25(OH)D and nutritional indicators, as well as biochemical and disease activity assessments, were conducted.
Results
Patients with CD and healthy participants were found to differ significantly in their 25(OH)D levels as well in levels of nutritional and inflammatory indicators. The optimal VD cut‐off value was found to be 46.81 nmol/L for CD development and 35.32 nmol/L for disease activity. Levels of 25(OH)D were correlated with both nutritional status and inflammation.
Conclusions
The VD level is likely to be a useful additional tool in the evaluation of CD patients and predicting the disease activity and clinical response. The VD level may relate both to the nutritional status and levels of inflammation in CD patients, and disease progression.
Highlights
1.
This study included the NRS‐2002 and PG‐SGA scores to provide a comprehensive picture of the nutritional status with Crohn's disease (CD).
2.
We found serum 25(OH)D levels were associated with both nutritional status and inflammation.
3.
Receiver operating characteristic analysis was used to determine the optimal vitamin D cut‐off values for predicting CD development and assessing disease activity.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Hepatocellular carcinoma (HCC) often presents with multiple nodules within the liver, with limited effective interventions. The high genetic heterogeneity of HCC might be the major cause of treatment ...failure. We aimed to characterize genomic heterogeneity, infer clonal evolution, investigate RNA expression pattern and explore tumour immune microenvironment profile of multifocal HCC.
Whole-exome sequencing and RNA sequencing were carried out in 34 tumours and 6 adjacent normal liver tissue samples from 6 multifocal HCC patients. Protein expression of Ki67, AFP, P53, Survivin and CD8 was detected by immunohistochemistry. Fluorescence in situ hybridization was carried out to validate the amplification status of sorafenib-targeted genes.
We deciphered genomic and transcriptional heterogeneity among tumours in each multifocal HCC patient including mutational profiles, copy number alterations, tumour evolutionary trajectory and tumour immune microenvironment profiles. Of note, sorafenib-targeted alterations were identified in the trunk of phylogenetic tree in only one out of the six patients, which may explain the relative low treatment response rate to sorafenib in clinical practice. Moreover, we demonstrated RNA expression patterns and tumour immune microenvironment profiles of all nodules. We found that RNA expression pattern was associated with Edmondson–Steiner grading. Based on the differential expression of 66 reported immune markers, unsupervised hierarchical clustering analysis of 34 nodules identified immune subsets: one low expression cluster with seven nodules and one high expression cluster with 11 nodules. CD8+ T cells were more enriched in nodules of the high expression cluster.
Our study provided a detailed view of genomic and transcriptional heterogeneity, clonal evolution and immune infiltration of multifocal HCC. The heterogeneity of druggable targets and immune landscape might help interpret the clinical responsiveness to targeted drugs and immunotherapy for multifocal HCC patients.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
High-energy photons from the Crab Nebula
The Crab Nebula contains a pulsar that excites the surrounding gas to emit high-energy radiation. The combination of the pulsar's youth and nearby location ...makes the nebula the brightest gamma-ray source in the sky. The LHAASO Collaboration report observations of this source at energies of tera– to peta–electron volts, extending the spectrum of this prototypical object. They combine these data with observations at lower energies to model the physics of the emission process. The multiwave-length data can be explained by a combination of synchrotron radiation and inverse Compton scattering.
Science
, abg5137, this issue p.
425
Detection of the Crab Nebula at peta–electron volt energies constrains the gamma-ray emission mechanism.
The Crab Nebula is a bright source of gamma rays powered by the Crab Pulsar’s rotational energy through the formation and termination of a relativistic electron-positron wind. We report the detection of gamma rays from this source with energies from 5 × 10
−4
to 1.1 peta–electron volts with a spectrum showing gradual steepening over three energy decades. The ultrahigh-energy photons imply the presence of a peta–electron volt electron accelerator (a pevatron) in the nebula, with an acceleration rate exceeding 15% of the theoretical limit. We constrain the pevatron’s size between 0.025 and 0.1 parsecs and the magnetic field to ≈110 microgauss. The production rate of peta–electron volt electrons, 2.5 × 10
36
ergs per second, constitutes 0.5% of the pulsar spin-down luminosity, although we cannot exclude a contribution of peta–electron volt protons to the production of the highest-energy gamma rays.
In this paper, we report on the discovery of an optical flare observed in the R band from the red-dwarf eclipsing binary CU Cancri, whose component stars are at the upper boundary of full convection ...(M
1= 0.43 M⊙ and M
2= 0.4 M⊙, where M⊙ is the solar mass). The amplitude of the flare is the largest among those detected in the R band (∼0.52 mag) and the duration time is about 73 min. Like flares observed on the Sun, quasi-periodic oscillations were seen during and after the flare. Three more R-band flares were found by follow-up monitoring. In total, this binary was monitored photometrically by using an R filter for 79.9 h, which has revealed an R-band flare rate of about 0.05 flares per hour. Together with other strong chromospheric and coronal activities (i.e. very strong Hα and Hβ emission features and an extreme ultraviolet and X-ray source), these detections indicate that it has very strong magnetic activity. Therefore, the apparent faintness (∼1.4 mag in the V band) of CU Cnc, compared with other single red dwarfs of the same mass, can be plausibly explained by the high coverage of dark spots.
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BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
ABSTRACT
Using the precise times of mid‐egress of the eclipsing polar HU Aqr, we discovered that this polar is orbited by two or more giant planets. The two planets detected so far have masses of at ...least 5.9 and 4.5MJup. Their respective distances from the polar are 3.6 and 5.4 au with periods of 6.54 and 11.96 yr, respectively. The observed rate of decrease of period derived from the downward parabolic change in the observed − calculated (O − C) curve is a factor of 15 larger than the value expected for gravitational radiation. This indicates that it may be only a part of a long‐period cyclic variation, revealing the presence of one more planet. It is interesting to note that the two detected circumbinary planets follow the Titus–Bode law of solar planets with n= 5 and 6. We estimate that another 10 yr of observations will reveal the presence of the predicted third planet.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Recently, the LHAASO Collaboration published the detection of 12 ultrahigh-energy γ-ray sources above 100 TeV, with the highest energy photon reaching 1.4 PeV. The first detection of PeV γ rays from ...astrophysical sources may provide a very sensitive probe of the effect of the Lorentz invariance violation (LIV), which results in decay of high-energy γ rays in the superluminal scenario and hence a sharp cutoff of the energy spectrum. Two highest energy sources are studied in this work. No signature of the existence of the LIV is found in their energy spectra, and the lower limits on the LIV energy scale are derived. Our results show that the first-order LIV energy scale should be higher than about 10^{5} times the Planck scale M_{Pl} and that the second-order LIV scale is >10^{-3}M_{Pl}. Both limits improve by at least one order of magnitude the previous results.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying the northern γ-ray sky at energies above 10 TeV with unprecedented sensitivity. γ-ray ...observations have long been one of the most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by the decays of heavy dark matter particles. In this Letter, we present the first dark matter analysis with LHAASO-KM2A, using the first 340 days of data from 1/2-KM2A and 230 days of data from 3/4-KM2A. Several regions of interest are used to search for a signal and account for the residual cosmic-ray background after γ/hadron separation. We find no excess of dark matter signals, and thus place some of the strongest γ-ray constraints on the lifetime of heavy dark matter particles with mass between 10^{5} and 10^{9} GeV. Our results with LHAASO are robust, and have important implications for dark matter interpretations of the diffuse astrophysical high-energy neutrino emission.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
The Wide Field-of-View Cherenkov Telescope Array (WFCTA) and the Water Cherenkov Detector Array (WCDA) of LHAASO are designed to work in combination for measuring the energy spectra of the cosmic ray ...species over a very wide energy range from a few TeV to 10 PeV. The energy calibration can be achieved with a proven technique of measuring the westward shift of the Moon shadow cast by galactic cosmic rays due to the geomagnetic field. This deflection angle Δ is inversely proportional to the cosmic ray rigidity. The precise measurement of the shifts by WCDA allows us to calibrate its energy scale for energies as high as 35 TeV. Through a set of commonly triggered events, the energy scales can be propagated to WFCTA. The energies of the events can be derived both by WCDA-1 and WFCTA with the median energies 23.4 ± 0.1 ± 1.3 TeV and ( 21.9 ± 0.1 TeV ), respectively, which are consistent within uncertainties. In addition, the propagation of the energy scale is also validated by the Moon shadow based on the same data selection criteria of the commonly triggered events. This paper reports, for the first time, an observational measurement of the absolute energy scale of the primary cosmic rays generating showers observed by air Cherenkov telescopes.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
ABSTRACT
By using six newly determined mid‐eclipse times together with those collected from the literature, we have found that the observed minus calculated (O−C) curve of RR Cae shows a cyclic ...change with a period of 11.9 yr and an amplitude of 14.3 s while it undergoes an upward parabolic variation revealing a long‐term period increase at a rate of . The cyclic change was analysed for the light‐travel‐time effect that arises from the gravitational influence of a third companion. The mass of the third body was determined to be M3sin i′= 4.2(± 0.4) MJup, suggesting that it is a circumbinary giant planet when its orbital inclination is larger than 176. The orbital separation of the circumbinary planet from the central eclipsing binary is about 5.3(± 0.6) au. The period increase is opposite to the changes caused by angular momentum loss via magnetic braking or/and gravitational radiation; and it cannot be explained by the mass transfer between both components because of its detached configuration. These indicate that the observed upward parabolic change is only a part of a long‐period (longer than 26.3 yr) cyclic variation, which may reveal the presence of another giant circumbinary planet in a wide orbit.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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