Geopolymer is an emerging cementitious material characterized by better mechanical performance and more environmentally sustainable properties than ordinary Portland cement (OPC). Previous work ...mainly highlighted thermal behavior of metakaolin or fly ash-based geopolymers. This paper provides experimental data of geopolymer concrete manufactured with granulated blast furnace slag (GBFS) and fly ash after high temperature exposures of 400°C, 600°C, 800°C and 1 000°C in terms of ISO834. Residual compressive strength and splitting strength, as well as the effects of standing time were examined and compared with equivalent OPC concrete findings. The results revealed that both kinds of strength improved about 14% and 9% after being exposed to 400°C, and the reduction was less than OPC concrete. Additionally, the residual compressive strength after different exposures evolved variously with prolonging of standing time. On the basis of the results, the empirical equations of residual compressive strength and splitting strength of GC are established.
Abstract
Comparing the prediction effects of traditional econometric algorithm model and deep learning algorithm model, taking regional GDP as an example, two prediction models of ARMA-ECM and ...LSTM-SVR are established for prediction, and the prediction results of different models are compared and analyzed. The results show that there are some deviations in the prediction results of the two models, but the prediction trends are the same. The prediction accuracy of LSTM-SVR model will decrease significantly with the reduction of time series data samples, while ARMA-ECM model is not so sensitive.
Abstract
Urbanization is a key part of achieving a overall well-off society in it’s decisive stage. Accurately predicting the developing trend of urbanization rate has important practical ...significance for relevant departments to make strategic decisions. This article uses Stata software and the relevant data released by Data Center of the National Bureau of Statistics, selects the urbanization rate time series data of 31 provinces of China from 1990 to 2019, establishes an ARIMA model of urbanization rate and time, and predicts 2020 to 2050. Trend of urbanization rate in various regions. The data shows that, exclude individual areas, the urbanization rate of each area can reach 72% in 2030 and over 90% in 2050. However, the development of urbanization rates among regions is uneven, and relevant departments should formulate a reasonable development strategy on the basis of sustainable and balanced development
IQ motif-containing proteins can be recognized by calmodulin (CaM) and are essential for many biological processes. However, the role of IQ motif-containing proteins in spermatogenesis is largely ...unknown. In this study, we identified a loss-of-function mutation in the novel gene IQ motif-containing H ( IQCH ) in a Chinese family with male infertility characterized by a cracked flagellar axoneme and abnormal mitochondrial structure. To verify the function of IQCH, Iqch knockout (KO) mice were generated via CRISPR-Cas9 technology. As expected, the Iqch KO male mice exhibited impaired fertility, which was related to deficient acrosome activity and abnormal structures of the axoneme and mitochondria, mirroring the patient phenotypes. Mechanistically, IQCH can bind to CaM and subsequently regulate the expression of RNA-binding proteins (especially HNRPAB), which are indispensable for spermatogenesis. Overall, this study revealed the function of IQCH, expanded the role of IQ motif-containing proteins in reproductive processes, and provided important guidance for genetic counseling and genetic diagnosis of male infertility.
The strength and duration of STAT3 signaling are tightly controlled by multiple negative feedback mechanisms under physical conditions. However, how these serial feedback loops are simultaneously ...disrupted in cancers, leading to constitutive activation of STAT3 signaling in hepatocellular carcinoma (HCC), remains obscure. Here we report that miR-589-5p is elevated in HCC tissues, which is caused by recurrent gains. Overexpression of miR-589-5p correlates with poor overall and relapse-free survival in HCC patients. Upregulating miR-589-5p enhances spheroid formation ability, fraction of CD133 positive and side population cells, expression of cancer stem cell factors and the mitochondrial potential, and represses the apoptosis induced by doxorubicin in vitro and tumorigenicity in vivo in HCC cells; conversely, silencing miR-589-5p yields an opposite effect. Our findings further demonstrate miR-589-5p promotes the cancer stem cell characteristics and chemoresistance via targeting multiple negative regulators of STAT3 signaling pathway, including SOCS2, SOCS5, PTPN1 and PTPN11, leading to constitutive activation of STAT3 signaling. Collectively, our results unravel a novel mechanism by which miR-589-5p promotes the maintenance of stemness and chemoresistance in HCC, providing a potential rational registry of anti-miR-589-5p combining with conventional chemotherapy against HCC.
•miR-589-5p is significantly elevated in HCC tissues and cells.•Overexpression of miR-589-5p relates with poor overall and relapse-free survival of HCC patients.•miR-589-5p promotes stemness and chemoresistance in vitro and in vivo.•miR-589-5p promotes stemness and chemoresistance via activating STAT3 and signaling.•Recurrent gains contribute to miR-589-5p overexpression in HCC tissues.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
We previously demonstrated the experimental synthesis of one-dimensional van der Waals (1D vdW) heterostructures, where single-crystal boron nitride nanotubes (BNNT) and/or molybdenum disulfide ...nanotubes seamlessly wrap around a single-walled carbon nanotube (SWCNT) and form a coaxial hetero-nanotube with a diameter of only several nm. However, in that work, the inner-most templates are SWCNTs with mixed diameters and band structures, so the electronic property of the heterostructure is not controllable. In this work, we demonstrate the possibility of building 1D vdW heterostructures on atomically precise, single-chirality SWCNTs. This is achieved by a long route of dispersing, sorting, re-depositing and cleaning SWCNTs before performing the synthesis of 1D heterostructures. We employ five different single-chirality SWCNTs and confirm that 1D heterostructures can be fabricated on these solution-sorted SWCNT templates if the surfactant can be readily removed. The obtained heterostructures show a very minor variation in inner diameters, suggesting the high uniformity of the starting SWCNT template. Solution processes are found to have minor side effects and the defects are largely healed after the high temperature BNNT growth. As a result, the obtained heterostructures show a high crystal quality according to the spectroscopic and microscopic characterizations. Finally, we perform a structural analysis using (6, 5) SWCNT based 1D heterostructures as the example. Electron diffraction reveals an abundance of 80% of (6, 5) SWCNTs in the starting material, which allowed us to conveniently observe different types of BNNTs on SWCNTs of the identical chirality. We visualize that all zigzag, near-armchair, and chiral BNNTs can form on (6, 5) SWCNTs. As the property of a 1D heterostructure is largely affected by the inner-most template, being able to use atomically precise SWCNT as the starting material is an initial but critical step towards the fabrication of more function-designable 1D hetero-nanotube devices.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Electrochemically producing formate by oxidizing methanol is a promising way to add value to methanol. Noble metal-based electrocatalysts, which have been extensively studied for the methanol ...oxidation reaction, can catalyze the complete oxidation of methanol to carbon dioxide, but not the mild oxidation to formate. As a result, exploring efficient and earth-abundant electrocatalysts for formate production from methanol is of interest. Herein, we present the electro-oxidation of methanol to formate, catalyzed by iron-substituted lanthanum cobaltite (LaCo1−xFexO3). The Fe/Co ratio in the oxides greatly influences the activity and selectivity. This effect is attributed to the higher affinity of Fe and Co to the two reactants: CH3OH and OH−, respectively. Because a balance between these affinities is favored, LaCo0.5Fe0.5O3 shows the highest formate production rate, at 24.5 mmol h−1 goxide−1, and a relatively high Faradaic efficiency of 44.4% in a series of (LaCo1−xFexO3) samples (x = 0.00, 0.25, 0.50, 0.75, 1.00) at 1.6 V versus a reversible hydrogen electrode.
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•Electro-oxidation of methanol to formate is catalyzed by iron substituted lanthanum cobaltite (LaCo1−xFexO3).•The Fe/Co ratio in the oxides greatly influences the activity and selectivity.•DFT calculations revealed the influence of iron substitution on the activity and selectivity.•(LaCo0.5Fe0.5O3) shows the highest formate production rate of 24.5 mmol h−1 goxide−1 and a relatively high Faradaic efficiency of 44.4%.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Autophagy is a universal degradation system in eukaryotic cells. In plants, although autophagosome biogenesis has been extensively studied, the mechanism of how autophagosomes are transported to the ...vacuole for degradation remains largely unexplored. In this study, we demonstrated that upon autophagy induction, Arabidopsis homotypic fusion and protein sorting (HOPS) subunit VPS41 converts first from condensates to puncta, then to ring-like structures, termed VPS41-associated phagic vacuoles (VAPVs), which enclose autophagy-related gene (ATG)8s for vacuolar degradation. This process is initiated by ADP ribosylation factor (ARF)-like GTPases ARLA1s and occurs concurrently with autophagy progression through coupling with the synaptic-soluble N-ethylmaleimide-sensitive factor attachment protein rmleceptor (SNARE) proteins. Unlike in other eukaryotes, autophagy degradation in Arabidopsis is largely independent of the RAB7 pathway. By contrast, dysfunction in the condensates-to-VAPVs conversion process impairs autophagosome structure and disrupts their vacuolar transport, leading to a significant reduction in autophagic flux and plant survival rate. Our findings suggest that the conversion pathway might be an integral part of the autophagy program unique to plants.
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•VPS41 converts from condensates to VAPVs upon autophagy induction•Autophagy degradation in Arabidopsis is largely independent of the RAB7 pathway•The condensates-to-VAPVs conversion pathway is essential for autophagy degradation•The condensates-to-VAPVs conversion pathway is crucial for normal autophagy progression
In plants, the process through which autophagosomes are transported to the vacuole for degradation remains largely unknown. Jiang et al. report a condensates-to-VAPVs conversion pathway, which plays an essential role in the vacuolar transport of autophagosomes and the normal progression of autophagy.
Abstract
Oocyte maturation arrest, fertilization failure, and early embryonic arrest are important causes of female infertility, whereas the genetic events that contribute to these processes are ...largely unknown. Loss‐of‐function of PABPC1L in mice has been suggested to cause female infertility involved in the absence of mature oocytes or embryos in vivo or in vitro. However, the role of PABPC1L in human female reproduction remains largely elusive. In this study, we identified a homozygous missense mutation (c.536G>A, p.R179Q) and a compound heterozygous mutation (c.793C>T, p.R265W; c.1201C>T, p.Q401*) in
PABPC1L
in two unrelated infertile females characterized by recurrent oocyte maturation abnormalities and early embryonic arrest. These variants resulted in nonfunctional PABPC1L protein and were associated with impaired chromatin configuration and transcriptional silencing in GV oocytes. Moreover, the binding capacity of mutant PABPC1L to mRNAs related to oocyte maturation and early embryonic development was decreased significantly. Our findings revealed novel
PABPC1L
mutations causing oocyte maturation abnormalities and early embryonic arrest, confirming the essential role of
PABPC1L
in human female fertility.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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