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  • Tissue-Resident Memory T Ce... Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway
    Weisberg, Stuart P.; Carpenter, Dustin J.; Chait, Michael ... Cell reports (Cambridge), 12/2019, Volume: 29, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Non-recirculating tissue-resident memory T cells (TRMs) are the predominant T cell subset in diverse tissue sites, where they mediate protective immune responses in situ. Here, we reveal a role for ...
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Available for: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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  • Identification of novel thy... Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6
    Danzl, Nichole M; Jeong, Seihwan; Choi, Yongwon ... PloS one, 01/2014, Volume: 9, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Thymic epithelial cells (TECs) are critical for the normal development and function of the thymus. Here, we examined the developmental stages of TECs using quantitative assessment of the cortical and ...
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Available for: DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK

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  • Harnessing Hematopoietic St... Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro
    Luchsinger, Larry L.; Strikoudis, Alexandros; Danzl, Nichole M. ... Cell stem cell, 08/2019, Volume: 25, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    The specific cellular physiology of hematopoietic stem cells (HSCs) is underexplored, and their maintenance in vitro remains challenging. We discovered that culture of HSCs in low calcium increased ...
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Available for: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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  • Thymic epithelial cells: an... Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development
    Alexandropoulos, Konstantina; Danzl, Nichole M. Immunologic research, 12/2012, Volume: 54, Issue: 1-3
    Journal Article
    Peer reviewed

    During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two ...
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  • Human stem cell-derived thy... Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus
    Gras-Peña, Rafael; Danzl, Nichole M.; Khosravi-Maharlooei, Mohsen ... Journal of allergy and clinical immunology, 05/2022, Volume: 149, Issue: 5
    Journal Article
    Peer reviewed

    Generation of thymic tissue from pluripotent stem cells would provide therapies for acquired and congenital thymic insufficiency states. This study aimed to generate human thymic epithelial ...
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  • Lymphohematopoietic graft-v... Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation
    Fu, Jianing; Zuber, Julien; Shonts, Brittany ... The Journal of clinical investigation, 04/2021, Volume: 131, Issue: 8
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    Open access

    In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism often develops. Donor T cell macrochimerism (≥4%) frequently occurs without graft-versus-host disease ...
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  • Rapid thymectomy of NSG mic... Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice
    Khosravi‐Maharlooei, Mohsen; Hoelzl, Markus; Li, Hao Wei ... European journal of immunology, January 2020, Volume: 50, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune ...
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  • Medullary thymic epithelial... Medullary thymic epithelial cell depletion leads to autoimmune hepatitis
    Bonito, Anthony J; Aloman, Costica; Fiel, M Isabel ... The Journal of clinical investigation, 08/2013, Volume: 123, Issue: 8
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    Open access

    TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development. mTECs regulate T cell tolerance by ectopically ...
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  • Defects in Long-Term APC Re... Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs
    Nauman, Grace; Danzl, Nichole M; Lee, Jaeyop ... The Journal of immunology (1950), 04/2022, Volume: 208, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Immunodeficient mice reconstituted with immune systems from patients, or personalized immune (PI) mice, are powerful tools for understanding human disease. Compared with immunodeficient mice ...
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  • Regulation of medullary thy... Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin
    Danzl, Nichole M; Donlin, Laura T; Alexandropoulos, Konstantina The Journal of experimental medicine, 05/2010, Volume: 207, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Medullary thymic epithelial cells (mTECs) play an important role in T cell tolerance and prevention of autoimmunity. Mice deficient in expression of the signaling protein Sin exhibit exaggerated ...
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