Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin-sensitized splenocytes activated in vitro with mouse thyroglobulin and interleukin-12. In wild-type (WT) ...DBA/1 recipients of WT donor splenocytes, thyroid lesions reach maximal severity at day 20, with ongoing inflammation and extensive fibrosis at day 60. Our previous studies indicated the site of expression of FLIP and Fas ligand thyroid epithelial cells (TECs) versus inflammatory cells differed in mice when lesions would resolve or progress to fibrosis. To test the hypothesis that expression of FLIP by TECs would promote earlier G-EAT resolution in DBA/1 mice, transgenic (Tg) DBA/1 mice expressing FLIP on TECs were generated. In FLIP Tg+ and Tg− littermate recipients of WT donor splenocytes, G-EAT severity was comparable at day 20, but fibrosis was decreased, and many lesions resolved by day 60 in Tg+ but not Tg− recipients. FLIP and Fas ligand were primarily expressed by TECs in Tg+ recipients and by inflammatory cells in Tg− recipients at day 60. Apoptosis of inflammatory cells was greater, and expression of proinflammatory cytokines was decreased in thyroids of Tg+ compared with Tg− recipients. These results are consistent with the hypothesis that transgenic expression of FLIP on thyroid epithelial cells promotes earlier resolution of granulomatous experimental autoimmune thyroiditis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
174.
Elections and public health DeMarco, V; Schneider, G E
American journal of public health (1971),
10/2000, Volume:
90, Issue:
10
Journal Article
Peer reviewed
Open access
An editorial addresses a voter education campaign launched by Marylanders Against Handgun Abuse. The upcoming presidential elections will have a dramatic impact on public health. Electing candidates ...who will protect the public health is a responsibility that should be taken seriously.
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CEKLJ, DOBA, FSPLJ, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
A low-resistivity RPC for the ALICE dimuon arm Arnaldi, R; Baldit, A; Barret, V ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
09/2000, Volume:
451, Issue:
2
Journal Article
Peer reviewed
In view of ALICE, the dedicated Heavy-Ion Experiment at LHC, a Resistive Plate Chamber (RPC) with electrodes made of low-resistivity bakelite (
ρ≃3.5×10
9
Ω
cm
) has been tested at the CERN SPS both ...in streamer and in avalanche mode. The chamber has shown a stable behaviour and excellent rate capability: its efficiency is better than 95% for local particle fluxes of about 1 and 10 kHz/cm
2 for operation in streamer and in avalanche mode, respectively. The cluster size and the time resolution have also been measured for both modes of operation.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The ability of arachidonic acid (AA) and prostaglandins of the two series to induce parturition in vivo and oviducal contraction in vitro was studied in the viviparous lizard Sceloporus jarrovi. ...Injection of PGF2 alpha, PGE2, or AA during late pregnancy stimulated parturition within 2 hr in a threshold-dependent fashion. In contrast, during mid pregnancy, females did not respond. Surgically removed and cultured oviducts from females in late pregnancy gave "birth" in response to AA, PGF2 alpha, and PGE2. Oviducts from S. jarrovi in mid pregnancy responded to PGF2 alpha but not to AA. Addition of arginine vasotocin, a potent stimulator of PG synthesis, either alone or with AA to oviduct cultures stimulated rapid and complete birth in vitro from oviducts obtained from late, but not mid pregnant, females. Stage of pregnancy mediates the response of the lizard oviduct to prostaglandin stimulation.
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