Gravitational-wave (GW) measurements of physical effects such as spin-induced quadrupole moments can distinguish binaries consisting of black holes from non-black hole binaries. While these effects ...may be poorly constrained for single-event inferences with the second-generation detectors, combining information from multiple detections can help uncover features of non-black hole binaries. The spin-induced quadrupole moment has specific predictions for different types of compact objects, and a generalized formalism must consider a population where different types of compact objects co-exist. In this study, we introduce a hierarchical mixture-likelihood formalism to estimate the {\it fraction of non-binary black holes in the population}. We demonstrate the applicability of this method using simulated GW signals injected into Gaussian noise following the design sensitivities of the Advanced LIGO Advanced Virgo detectors. We compare the performance of this method with a traditionally-followed hierarchical inference approach. Both the methods are equally effective to hint at inhomogeneous populations, however, we find the mixture-likelihood approach to be more natural for mixture populations comprising compact objects of diverse classes. We also discuss the possible systematics in the mixture-likelihood approach, caused by several reasons, including the limited sensitivity of the second-generation detectors, specific features of the astrophysical population distributions, and the limitations posed by the waveform models employed. Finally, we apply this method to the LIGO-Virgo detections published in the second GW transient catalog (GWTC-2) and find them consistent with a binary black hole population within the statistical precision.
According to the "no-hair" conjecture, a Kerr black hole (BH) is completely described by its mass and spin. In particular, the spin-induced quadrupole moment of a Kerr BH with mass \(m\) and ...dimensionless spin \(\chi\) can be written as \(Q=-\kappa\,m^3\chi^2\), where \(\kappa_{\rm BH}=1\). Thus by measuring the spin-induced quadrupole parameter \(\kappa\), we can test the binary black hole nature of compact binaries and distinguish them from binaries comprised of other exotic compact objects, as proposed in N. V. Krishnendu et al., PRL 119, 091101 (2017). Here, we present a Bayesian framework to carry out this test where we measure the symmetric combination of individual spin-induced quadrupole moment parameters fixing the anti-symmetric combination to be zero. The analysis is restricted to the inspiral part of the signal as the spin-induced deformations are not modeled in the post-inspiral regime. We perform detailed simulations to investigate the applicability of this method for compact binaries of different masses and spins and also explore various degeneracies in the parameter space which can affect this test. We then apply this method to the gravitational wave events, GW151226 and GW170608 detected during the first and second observing runs of Advanced LIGO and Advanced Virgo detectors. We find the two events to be consistent with binary black hole mergers in general relativity. By combining information from several more of such events in future, this method can be used to set constraints on the black hole nature of the population of compact binaries that are detected by the Advanced LIGO and Advanced Virgo detectors.
The interaction between the receptor FLT3 (FMS-like tyrosine kinase-3) and its ligand FL leads to crucial signalling during the early stages of the commitment of haematopoietic stem cells. Mutation ...or over-expression of the FLT3 gene, leading to constitutive signalling, enhances the survival and expansion of a variety of leukaemias and is associated with an unfavourable clinical outcome for acute myeloid leukaemia (AML) patients. In this study, we used a murine cellular model for AML and primary leukaemic cells from AML patients to investigate the molecular mechanisms underlying the regulation of FLT3 gene expression and identify its key cis- and trans-regulators. By assessing DNA accessibility and epigenetic markings, we defined regulatory domains in the FLT3 promoter and first intron. These elements permit in vivo binding of several AML-related transcription factors, including the proto-oncogene MYB and the CCAAT/enhancer binding protein C/EBPalpha, which are recruited to the FLT3 promoter and intronic module, respectively. Substantiating their relevance to the human disease, our analysis of gene expression profiling arrays from AML patients uncovered significant correlations between FLT3 expression level and that of MYB and CEBPA. The latter relationship permits discrimination between patients with CEBPA mono- and bi-allelic mutations, and thus connects two major prognostic factors for AML. Leukemia (2013) 27, 1487-1496; doi: 10.1038/leu.2013.23 Keywords: AML; C/EBP alpha; FLT3; MYB; regulation
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
An asymmetry in radii of curvature of the mirrors in the arms of an interferometric gravitational-wave detector can degrade the performance of such a detector. In addition, the non-perfect mirror ...surface figures can excite higher order modes if the radii of curvature are close to higher order mode degeneracy. In this paper, we present a novel technique for changing the radii of curvature of arm cavity end mirrors by Central Heating Radius of Curvature Correction. This system was installed in the Virgo experiment in Cascina and proved to be an efficient, non-invasive solution with a large dynamic range. We present how the interferometer was tuned using such a system in order to obtain the best duty-cycles and sensitivity achieved with Virgo to date.
The Advanced Virgo detector Agathos, M; Agatsuma, K; Astone, P ...
Journal of Physics: Conference Series,
05/2015, Volume:
610, Issue:
1
Journal Article, Conference Proceeding
Peer reviewed
Open access
The Advanced Virgo interferometer is the upgraded version of the Virgo detector having the goal to extend by a factor 10 the observation horizon in the universe and consequently increase the ...detection rate by three orders of magnitude. Its installation is in progress and is expected to be completed in late 2015. In this proceeding we will present the scheme and the main challenging technical features of the detector and we will give an outline of the installation status and the foreseen time schedule which will bring Advanced Virgo to its full operation.
The data collected by a gravitational wave interferometer are inevitably affected by instrumental artefacts and environmental disturbances. In particular, for continuous gravitational wave (CW) ...studies it is important to detect narrow-band disturbances (the so-called "noise lines") during science runs, and to help scientists to identify and possibly remove or mitigate their sources. The NoEMi (Noise Frequency Event Miner) framework exploits some of the algorithms implemented for the CW search to identify, on a daily basis, the frequency lines observed in the Virgo science data and in a subset of the environmental sensors, looking for lines that match in frequency. A line tracker algorithm reconstructs the lines over time, and stores them in a database, which is made accesible via a web interface. We describe the workflow of NoEMi, providing examples of its use for the investigation of noise lines in past Virgo runs (VSR2, VSR3) and in the most recent run (VSR4).
A recent study has shown that redshift information can be directly extracted from gravitational wave sources. This can be done by exploiting the tidal phasing contributions to the waveform during the ...inspiral phase of binary neutron stars coalescences. The original study investigated the viability of this idea in the context of the Einstein Telescope using a Fisher Matrix approach and in this paper, we further explore this idea using realistic simulations and Bayesian inference techniques. We find that the fractional accuracy with which the redshift can be measured is in the order of tens of percent, in agreement with Fisher Matrix predictions. Moreover, no significant bias is found. We conclude that, when tidal phasing contributions are included in the analysis, inference of the cosmological parameters from gravitational waves is possible
The understanding of noise in interferometric gravitational wave detectors is fundamental in terms of both enabling prompt reactions in the mitigation of noise disturbances and in the establishment ...of appropriate data-cleaning strategies. Monitoring tools to perform online and offline noise analysis in areas such as transient signal detection, line identification algorithms and coherence are used to characterise the Virgo detector noise. In this paper, we describe the framework into which these tools are integrated - the Noise Monitor Application Programming Interface (NMAPI) - and provide examples of its application.
The upcoming European design study `Einstein gravitational-wave Telescope' represents the first step towards a substantial, international effort for the design of a third-generation interferometric ...gravitational wave detector. It is generally believed that third-generation instruments might not be installed into existing infrastructures but will provoke a new search for optimal detector sites. Consequently, the detector design could be subject to fewer constraints than the on-going design of the second generation instruments. In particular, it will be prudent to investigate alternatives to the traditional L-shaped Michelson interferometer. In this article, we review an old proposal to use three Michelson interferometers in a triangular configuration. We use this example of a triple Michelson interferometer to clarify the terminology and will put this idea into the context of more recent research on interferometer technologies. Furthermore the benefits of a triangular detector will be used to motivate this design as a good starting point for a more detailed research effort towards a third-generation gravitational wave detector.
![C/EBP[alpha] and MYB regula...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/0887-6924/small "C/EBP[alpha] and MYB regulate FLT3 expression in AML.(ORIGINAL ARTICLE)")
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