Cu2MnSnS4 thin film was successfully prepared by a sol-gel technique on soda lime glass substrate from metal salts and thiourea. The structural and morphological properties of the fabricated film ...were characterized by X-ray diffraction, Raman spectroscopy, scanning electron microscopy and atomic force microscopy. The combination of the X-ray diffraction results and Raman spectroscopy reveal that this obtained layer is composed by Cu2MnSnS4 phase and has a stannite structure with preferential orientation along the (112) direction. The scanning electron microscopy and atomic force microscopy results show that the synthesized thin film is smooth and compact without any visible cracks or pores. The band gap of the Cu2MnSnS4 thin film is about 1.29 eV determined by the UV-vis-NIR absorption spectra measurement, which indicates it has potential applications in solar cells.
PbZrxTi1-xO3 (PZT) films were fabricated on FTO substrates by using precursor solutions containing polyvinylpyrrolidone additive and spinning-coating/annealing process. The correlation of the ...formation, ferroelectric, dielectric and optical reflection features of the layered PZT films with Zr/Ti atomic ration had been studied. It was found that each PZT film was fully crystallized and displayed a polycrystalline phase. The PZT films with Zr content ∼ 0.4–0.6 showed clearly distinguishable layered structures, and exhibited excellent ferroelectric and dielectric properties, together with good optical performance as dielectric mirrors. These PZT films possessed high reflectivity bands, the band widths were all over 50 nm and the peak reflectivities were more than 70%. They also had dielectric constants >550 Fm−1 at 10 KHz, remnant polarizations >24 μC/cm2 at 100 V polarizing voltage, rendering their potential application in photonic band gap engineering and integrated optoelectronics.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types of tumor. However, such mutations are not clear biomarkers for disease, since they are ...frequently detected in healthy individuals. Instead, it has become clear that elevated levels of Ras activity are critical for Ras-induced tumorigenesis. However, the mechanisms underlying the production of pathological levels of Ras activity are unclear. Here, we show that in the presence of oncogenic Ras, inflammatory stimuli initiate a positive feedback loop involving NF-kappaB that further amplifies Ras activity to pathological levels. Stimulation of Ras signaling by typical inflammatory stimuli was transient and had no long-term sequelae in wild-type mice. In contrast, these stimuli generated prolonged Ras signaling and led to chronic inflammation and precancerous pancreatic lesions (PanINs) in mice expressing physiological levels of oncogenic K-Ras. These effects of inflammatory stimuli were disrupted by deletion of inhibitor of NF-kappaB kinase 2 (IKK2) or inhibition of Cox-2. Likewise, expression of active IKK2 or Cox-2 or treatment with LPS generated chronic inflammation and PanINs only in mice expressing oncogenic K-Ras. The data support the hypothesis that in the presence of oncogenic Ras, inflammatory stimuli trigger an NF-kappaB-mediated positive feedback mechanism involving Cox-2 that amplifies Ras activity to pathological levels. Because a large proportion of the adult human population possesses Ras mutations in tissues including colon, pancreas, and lung, disruption of this positive feedback loop may be an important strategy for cancer prevention.
Although the molecular basis of flowering time control is well dissected in the long day （LD） plant Arabidopsis, it is still largely unknown in the short day （SD） plant rice. Rice flowering time ...（heading date） is an important agronomic trait for season adaption and grain yield, which is affected by both genetic and environmental factors. During the last decade, as the nature of florigen was identified, notable progress has been made on exploration how florigen gene ,expression is genetically controlled. In Arabidopsis expression of certain key flowering integrators such as FLOWERING LOCUS C （FLC） and FLOWERING LOCUS T （FT） are also epige- netically regulated by various chromatin modifications, however, very little is known in rice on this aspect until very recently. This review summarized the advances of both genetic networks and chromatin modifications in rice flowering time control, attempting to give a complete view of the genetic and epigenetic architecture in complex network of rice flowering pathways.
Customer Segment Application of Machine Learning in Business Operation of China Mobile Li, Qiaoyu; Yang, Wei; Liu, Ying ...
2020 IEEE 22nd International Conference on High Performance Computing and Communications; IEEE 18th International Conference on Smart City; IEEE 6th International Conference on Data Science and Systems (HPCC/SmartCity/DSS),
2020-Dec.
Conference Proceeding
The purpose of this paper is to use machine learning technology to build more user profiles in the process of customer segmentation to assist marketing decision-making. Specifically, by introducing ...cross features into the construction of Feature Engineering, the accuracy of target group prediction can be further improved and the user subgroup after feature crossing can be mined. In addition, this paper also proposes an improved decision tree model, which can build more comprehensive user profiles, and then assist in intelligent marketing. Firstly, both methods need to preprocess the data. In addition, for the subsequent feature crossing, it is necessary to discretize the continuous features and implement one-hot encoding for all data. In the process of discretization, the paper realizes the automatic selection of better discrete granularity value. A specific example is given and a comparative experiment is carried out to verify the effectiveness of the method.
We report the design, fabrication and measurement of a weakly-coupled 7-core-10-mode fiber. The attenuation of LP01 mode is 0.22dB/km and the crosstalk of the cores are less than −50dB/km. This ...FM-MCF can be used in weakly-coupled SDM systems that allows to multiply the capacity.
To engineer patient‐derived cells into therapy‐purposed biologics is a promising solution to realize personalized treatments. Without using gene‐editing technology, a live cell‐typed therapeutic is ...engineered for tumor treatment by artificially reprogramming macrophages with hyaluronic acid‐decorated superparamagnetic iron oxide nanoparticles (HIONs). This nanoparticle‐assisted cell‐reprogramming strategy demonstrates profound advantages, due to the combined contributions from the biological regulation of HIONs and the intrinsic nature of macrophages. Firstly, the reprogrammed macrophages present a substantial improvement in their innate capabilities, such as more effective tumor targeting and more efficient generation of bioactive components (e.g., reactive oxygen species, bioactive cytokines) to suppress tumor growth. Furthermore, this cell therapeutic exhibits cytostatic/proapoptotic effects specific to cancer cells. Secondly, HIONs enable macrophages more resistant to the intratumoral immunosuppressive environment. Thirdly, the macrophages are endowed with a strong ability to prime in situ protumoral M2 macrophages into antitumor M1 phenotype in a paracrine‐like manner. Consequently, a synergistic tumor‐inhibition effect is achieved. This study shows that engineering nanomaterial‐reprogrammed live cells as therapeutic biologics may be a more preferable option to the commonly used approaches where nanomaterials are administrated to induce bioresponse of certain cells in vivo.
A live cell‐typed therapeutic is engineered for tumor treatment by reprogramming macrophages with HION nanoparticles. The advantage of this ex vivo cell‐reprogramming strategy is evidenced by cancer‐cell‐specific toxicity, more efficient production of bioactive components, stronger resistance against intratumoral immunosuppression, and favorable ability to prime in situ protumoral M2 macrophages into antitumor M1 phenotype in a paracrine‐like manner.
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