ABSTRACT We perform Lyman- (Ly ) Monte-Carlo radiative transfer calculations on a suite of 2500 models of multiphase, outflowing media, which are characterized by 14 parameters. We focus on the Ly ...spectra emerging from these media and investigate which properties are dominant in shaping the emerging Ly profile. Multiphase models give rise to a wide variety of emerging spectra, including single-, double-, and triple-peaked spectra. We find that the dominant parameters in shaping the spectra include (i) the cloud covering factor, fc, which is in agreement with earlier studies, and (ii) the temperature and number density of residual H i in the hot ionized medium. We attempt to reproduce spectra emerging from multiphase models with "shell models" which are commonly used to fit observed Ly spectra, and investigate the connection between shell-model parameters and the physical parameters of the clumpy media. In shell models, the neutral hydrogen content of the shell is one of the key parameters controlling Ly radiative transfer. Because Ly spectra emerging from multiphase media depend much less on the neutral hydrogen content of the clumps, the shell-model parameters such as H i column density (but also shell velocity and dust content) are generally not well matched to the associated physical parameters of the clumpy media.
We quantify the directional dependence of the escape fraction of Lyman α (Lyα) and non-ionizing UV-continuum photons from a multiphase medium, and investigate whether there exist directional ...enhancements in the Lyα equivalent width (EW). Our multiphase medium consists of spherically symmetric distributions of cold, dusty clumps embedded within a hot dust-free medium. We focus on three models from the analysis presented by Laursen et al. We find that for a Lyα and UV-continuum point source, it is possible to find an EW boost
$b(\theta ,\phi ) > 5 \bar{b}$
in a few per cent of sight lines, where
$\bar{b}$
denotes the boost averaged over all photons. For spatially extended sources this directional dependence vanishes quickly when the size of the UV emitting region exceeds the mean distance between cold dusty clumps. Our analysis suggests that directional EW boosting can occur, and that this is mostly driven by reduced escape fractions of UV photons (which gives rise to UV-continuum ‘shadows’), and less due to an enhanced Lyα escape fraction (or beaming), in certain directions.
ABSTRACT We give an overview of the Grism Lens Amplified Survey from Space (GLASS), a large Hubble Space Telescope program aimed at obtaining grism spectroscopy of the fields of 10 massive clusters ...of galaxies at redshift z = 0.308-0.686, including the Hubble Frontier Fields (HFF). The Wide Field Camera 3 (WFC3) yields near-infrared spectra of the cluster cores covering the wavelength range 0.81-1.69 m through grisms G102 and G141, while the Advanced Camera for Surveys in parallel mode provides G800L spectra of the infall regions of the clusters. The WFC3 spectra are taken at two almost orthogonal position angles in order to minimize the effects of confusion. After summarizing the scientific drivers of GLASS, we describe the sample selection as well as the observing strategy and data processing pipeline. We then utilize MACS J0717.5+3745, a HFF cluster and the first one observed by GLASS, to illustrate the data quality and the high-level data products. Each spectrum brighter than is visually inspected by at least two co-authors and a redshift is measured when sufficient information is present in the spectra. Furthermore, we conducted a thorough search for emission lines through all of the GLASS WFC3 spectra with the aim of measuring redshifts for sources with continuum fainter than We provide a catalog of 139 emission-line-based spectroscopic redshifts for extragalactic sources, including three new redshifts of multiple image systems (one probable, two tentative). In addition to the data itself, we also release software tools that are helpful to navigate the data.
Fascinating about classical major histocompatibility complex (MHC) molecules is their polymorphism. The present study is a review and discussion of the fish MHC situation. The basic pattern of MHC ...variation in fish is similar to mammals, with MHC class I versus class II, and polymorphic classical versus nonpolymorphic nonclassical. However, in many or all teleost fishes, important differences with mammalian or human MHC were observed: (1) The allelic/haplotype diversification levels of classical MHC class I tend to be much higher than in mammals and involve structural positions within but also outside the peptide binding groove; (2) Teleost fish classical MHC class I and class II loci are not linked. The present article summarizes previous studies that performed quantitative trait loci (QTL) analysis for mapping differences in teleost fish disease resistance, and discusses them from MHC point of view. Overall, those QTL studies suggest the possible importance of genomic regions including classical MHC class II and nonclassical MHC class I genes, whereas similar observations were not made for the genomic regions with the highly diversified classical MHC class I alleles. It must be concluded that despite decades of knowing MHC polymorphism in jawed vertebrate species including fish, firm conclusions (as opposed to appealing hypotheses) on the reasons for MHC polymorphism cannot be made, and that the types of polymorphism observed in fish may not be explained by disease-resistance models alone.
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X-linked adrenoleukodystrophy (ALD), a progressive neurodegenerative disease, is caused by mutations in ABCD1 and characterized by very-long-chain fatty acids (VLCFA) accumulation. Virtually all ...males develop progressive myelopathy (AMN). A subset of patients, however, develops a fatal cerebral demyelinating disease (cerebral ALD). Hematopoietic stem cell transplantation is curative for cerebral ALD provided the procedure is performed in an early stage of the disease. Unfortunately, this narrow therapeutic window is often missed. Therefore, an increasing number of newborn screening programs are including ALD. To identify new biomarkers for ALD, we developed an Abcd1 knockout mouse with enhanced VLCFA synthesis either ubiquitous or restricted to oligodendrocytes. Biochemical analysis revealed VLCFA accumulation in different lipid classes and acylcarnitines. Both C26:0-lysoPC and C26:0-carnitine were highly elevated in brain, spinal cord, but also in bloodspots. We extended the analysis to patients and confirmed that C26:0-carnitine is also elevated in bloodspots from ALD patients. We anticipate that validation of C26:0-carnitine for the diagnosis of ALD in newborn bloodspots may lead to a faster inclusion of ALD in newborn screening programs in countries that already screen for other inborn errors of metabolism.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We investigate the radiative transfer of Lyα photons through simplified anisotropic gas distributions, which represent physically motivated extensions of the popular shell models. Our study is ...motivated by the notion that (i) shell models do not always reproduce observed Lyα spectral line profiles; (ii) (typical) shell models do not allow for the escape of ionizing photons; and (iii) the observation and expectation that winds are more complex, anisotropic phenomena. We examine the influence of inclination on the Lyα spectra, relative fluxes and escape fractions. We find the flux to be enhanced/suppressed by factors up to a few depending on the parameter range of the models, corresponding to a boost in equivalent width of the same amplitude if we neglect dust. In general, lower mean optical depths tend to reduce the impact of anisotropies as is expected. We find a correlation between an observed peak in the – occasionally triple-peaked – spectrum at the systemic velocity and the existence of a low optical depth cavity along the line of sight. This can be of importance in the search for ionizing photons leaking from high- redshift galaxies since these photons will also be able to escape through the cavity.
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