The power supplies presented in this article are used as part of the charged particle beam orbit correction system of the injection complex at SRF SKIF. The MPS-20 and MPS-6 (magnetic power supply) ...and PA-3 (power amplifier) power suppliers presented in the paper can provide electromagnets with currents reaching ±20, ±6, and ±3 A, respectively. All power sources are remotely monitored and controlled via the Ethernet and are made using modern components according to the Euromechanics standard.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The reaction of methyl 4-aryl-2,4-dioxobut-2-enoates with 4-aminobenzenesulfonamide in acetic acid–ethanol (1: 1) afforded methyl (2
Z
)-4-aryl-4-oxo-2-(4-sulfamoylanilino)but-2-enoates which reacted ...with ninhydrin in glacial acetic acid to give 3-aroyl-4-(4-sulfamoylanilino-5
H
-spirofuran-2,2′-indene-1′,3′,5-triones.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
—For the first time, we present a rupture surface model of the 2010 Maule earthquake, Chile, based on the combination of satellite geodesy, InSAR, and satellite gravimetry data. The regularization ...method used for constructing the model allowed us to find a uniform displacement field on rupture surface provided that a slip rake is close to a given one. On average, the displacements on the rupture surface are about 5 m with a maximum displacement of 13.1 m. The rupture zone extends south of the Arauco Peninsula and reaches a depth of 42 km along the plate surface. Using the constructed seismic rupture model, we have modeled the process of viscoelastic relaxation of stresses that emerged in the lithosphere and upper mantle as a result of the earthquake in order to estimate the contribution of this process in the observed postseismic displacements. Surface displacement velocities mainly depend on the viscosity value adopted for the asthenosphere. The comparison of the calculated and measured displacements at low viscosity of the asthenosphere shows that when the displacements are measured far from rupture surface as it is the case with the ocean–ocean subduction zone earthquakes, the observed displacements can be explained by the process of viscoelastic relaxation with a low viscosity of the asthenosphere. In the cases when there are data on the displacements above rupture surface, e.g., for the 2010 Maule earthquake, explaining the observed displacements by stress relaxation process in the near zone of the rupture is not possible at any viscosity: the displacements substantially differ both in amplitude and direction. At the same time, the postseismic creep models fairly well agree with the entire set of the existing data. Therefore, there is no need to accept the hypothesis of a low-viscous asthenosphere in the region of the 2010 Maule earthquake. Previously, we arrived at the similar conclusion considering the modeling results for the Sumatran earthquake of 2004, Simushir earthquakes of 2006, and a number of other large earthquakes in the subduction zones.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Regulation of gene expression via microRNA is the key mechanism of response to biotic and abiotic stresses in plants. There are a lot of experimental data on the biological function of microRNAs in ...response to different stresses in various plant species. This review contains up-to-date information on molecular mechanisms of microRNA action in plants in response to abiotic stresses, including drought, salinity, mineral nutrient deficiency or imbalance.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Introduction. The multikinase inhibitors have demonstrated high clinical efficacy in treatment of the radioiodine refractory differentiated thyroid cancer. At the same time, the inclusion ...criteria in the studies has reflected a minimum set of characteristics important for beginning of use of these drugs and an approach that takes into account the tumor progression rate (the volume doubling time) in the absence of clinical manifestations of the disease that have made it possible to individualize the start of therapy. Aim. To describe and evaluate the barriers and drivers of use the “watch and wait” approach by Russian oncologists in treatment of the radioiodine refractory thyroid cancer. Materials and methods. We conducted 35 structured interviews with oncologists observing patients after radioiodine therapy in order to evaluate the “watch and wait” approach. unfortunately, data on use and prevalence of this approach in Russia are limited. The present study involved the use of deductive content analysis as well as analysis of implementation model of clinical guidelines and included investigation of issue of implementation of the “watch and wait” approach to current practice of therapy for radioiodine refractory differentiated thyroid cancer. One of the main tasks was to determine the influence of external factors on the treatment of this category of patients. Conclusion. Barriers and drivers of using “watch and wait” approach in the treatment of differentiated radioiodine refractory thyroid cancer are identified at several levels. for wide use of this approach, it is necessary to involve oncologists taking into account their attitude regarding changes in routine practices, patient expectations and to obtain additional data regarding its long-term effectiveness.
The dependence of the antigen-binding activity of immobilized antibodies on pH of a saturating buffer has been investigated. We analyzed 28 monoclonal antibodies (MCAs) produced by various hybridomas ...to three virus antigens, i.e., the nuclear p23 protein of hepatitis C virus (C core protein p23), p24 protein of HIV 1, and the surface antigen of hepatitis B virus (HBsAg). Antibodies were adsorbed on the surfaces of immune plates in acidic (pH 2.8), neutral (pH 7.5), and alkaline (pH 9.5) buffers. The binding of labeled antigens, i.e., biotinylated or conjugated with horseradish peroxidase, with immobilized antigens was tested. It was shown that 10 out of 28 analyzed MCAs (36%) considerably better preserved their antigen-binding activity if their passive adsorption was carried out on the surface of polystyrene plates in an acidic buffer (pH 2.8). This approach allowed constructing a highly sensitive sandwich method for HBsAg assay with a minimal reliably determined antigen concentration of 0.013–0.017 ng/ml. The described approach may be recommended for the optimization of sandwich methods and solid-phase competitive methods.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Objective
: The goal of this study was to examine the prevalence of anti-core+1 in “naive” patients with chronic hepatitis C and different stages of liver fibrosis infected by HCV subtypes 1b and 3a.
...Materials and methods
: A total of 86 “naive” patients (37 men and 49 women) with CHC observed in the Botkin infectious disease hospital in 2017, were included in this study. The average age was 50,7±2,7. Laboratory tests included ALT and bilirubin. In 53 patients, the fibrosis stage in the liver tissue was evaluated by the TE method using Fibroscan (Echosens, France). The presence of antibodies to the core+1 protein in blood serum samples was determined by the “inhouse” indirect ELISA method using synthetic peptides F10 and F13, which amino acid sequences correspond to the antigenic determinants of core+1 protein of the HCV subtypes 1b and 3a, respectively.
Results
: In total, anti-core + 1 were detected in 27 (31,4%) subjects. It has been shown that the detection rate of anticore+1 does not depend on the HCV subtype. The study has indicated no statistically significant dependence between the presence of anti-core+1 and biochemical activity es of the infectious process (ALT, bilirubin). Anti-core+1 were detected in patients with all stages of fibrosis, however, the detection rate of anti-core+1 was statistically higher in patients with stage F4 fibrosis than in patients without liver fibrosis.
Conclusion
: The obtained results suggest a possible role of the core+1 protein in the development of fibrosis. In the natural course of HCV infection, the detection of anti-core+1 can be considered as a prognostic marker for the progression of fibrosis in the liver tissue.
The reaction of methyl aroylpyruvates with 2-(4-aminobenzenesulfonamido)thiazole (norsulfazole) in acetic acid-ethanol (1: 1) afforded methyl (2
Z
...)-4-aryl-4-oxo-2-{4-(1,3-thiazol-2-yl)sulfamoylphenyl-amino} but-2-enoates which reacted with ninhydrin in glacial acetic acid to give 4-aroyl-3-{4-(1,3-thiazol-2-yl)-sulfamoylphenylamino} spiro2,5-dihydrofuran-5,2′-indane-2,1′,3′-triones.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The reaction of 4-aryl-2-hydroxy-4-oxo-
N
-{4-(1,3-thiazol-2-yl)sulfamoylphenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl-
N
...-{4-(1,3-thiazol-2-yl)sulfamoylphenyl}-1-phenyl-1
H
-pyrazole-3-carboxamides. Treatment of the latter with an equimolar amount of silver nitrate in ethanol–DMF (2:1) gave the corresponding silver salts, while 5-aryl-
N
-{4-(1,3-thiazol-2-yl)sulfamoylphenyl}-1-phenyl-1
H
-pyrazole-3-carboxamide sodium salts were obtained by reaction with sodium methoxide in methanol–DMF (1:1). The synthesized compounds were tested for analgesic, anti-inflammatory, and antimicrobial activities.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Additives for diminishing the content of carbon monoxide in gases formed in regeneration of the cracking catalyst without noble metals were synthesized and tested. As additives of this kind can serve ...mixed oxides based on copper, cerium, magnesium, and aluminum and manganese oxide supported by gamma aluminum oxide. Additives based on mixed oxides possess a high acidity and do not impair the activity of the catalytic system in the cracking reactions. In the efficiency (89.7–95.5%) in lowering the content of carbon monoxide, mixed oxides based on copper and cerium are comparable with the platinum-based additive KO-10 (96.8%). The activity of the additive based on manganese oxide depends on the sample calcination temperature, with the maximum efficiency in lowering the content of carbon monoxide (88.0%) reached at temperatures of 850–920°C.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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