Objective. In a previous study we demonstrated continuous translation, orientation and one-dimensional grasping control of a prosthetic limb (seven degrees of freedom) by a human subject with ...tetraplegia using a brain−machine interface (BMI). The current study, in the same subject, immediately followed the previous work and expanded the scope of the control signal by also extracting hand-shape commands from the two 96-channel intracortical electrode arrays implanted in the subject's left motor cortex. Approach. Four new control signals, dictating prosthetic hand shape, replaced the one-dimensional grasping in the previous study, allowing the subject to control the prosthetic limb with ten degrees of freedom (three-dimensional (3D) translation, 3D orientation, four-dimensional hand shaping) simultaneously. Main results. Robust neural tuning to hand shaping was found, leading to ten-dimensional (10D) performance well above chance levels in all tests. Neural unit preferred directions were broadly distributed through the 10D space, with the majority of units significantly tuned to all ten dimensions, instead of being restricted to isolated domains (e.g. translation, orientation or hand shape). The addition of hand shaping emphasized object-interaction behavior. A fundamental component of BMIs is the calibration used to associate neural activity to intended movement. We found that the presence of an object during calibration enhanced successful shaping of the prosthetic hand as it closed around the object during grasping. Significance. Our results show that individual motor cortical neurons encode many parameters of movement, that object interaction is an important factor when extracting these signals, and that high-dimensional operation of prosthetic devices can be achieved with simple decoding algorithms. ClinicalTrials.gov Identifier: NCT01364480.
ABSTRACT The Large Binocular Telescope Interferometer (LBTI) is a versatile instrument designed for high angular resolution and high-contrast infrared imaging (1.5-13 m). In this paper, we focus on ...the mid-infrared (8-13 m) nulling mode and present its theory of operation, data reduction, and on-sky performance as of the end of the commissioning phase in 2015 March. With an interferometric baseline of 14.4 m, the LBTI nuller is specifically tuned to resolve the habitable zone of nearby main-sequence stars, where warm exozodiacal dust emission peaks. Measuring the exozodi luminosity function of nearby main-sequence stars is a key milestone to prepare for future exo-Earth direct imaging instruments. Thanks to recent progress in wavefront control and phase stabilization, as well as in data reduction techniques, the LBTI demonstrated in 2015 February a calibrated null accuracy of 0.05% over a 3 hr long observing sequence on the bright nearby A3V star β Leo. This is equivalent to an exozodiacal disk density of 15-30 zodi for a Sun-like star located at 10 pc, depending on the adopted disk model. This result sets a new record for high-contrast mid-infrared interferometric imaging and opens a new window on the study of planetary systems.
The Large Binocular Telescope Interferometer (LBTI) enables nulling interferometric observations across the N band (8 to 13 m) to suppress a star's bright light and probe for faint circumstellar ...emission. We present and statistically analyze the results from the LBTI/Hunt for Observable Signatures of Terrestrial Systems survey for exozodiacal dust. By comparing our measurements to model predictions based on the solar zodiacal dust in the N band, we estimate a 1 median sensitivity of 23 zodis times the solar system dust surface density in its habitable zone (HZ; 23 zodis) for early-type stars and 48 zodis for Sun-like stars, where 1 zodi is the surface density of HZ dust in the solar system. Of the 38 stars observed, 10 show significant excess. A clear correlation of our detections with the presence of cold dust in the systems was found, but none with the stellar spectral type or age. The majority of Sun-like stars have relatively low HZ dust levels (best-fit median: 3 zodis, 1 upper limit: 9 zodis, 95% confidence: 27 zodis based on our N band measurements), while ∼20% are significantly more dusty. The solar system's HZ dust content is consistent with being typical. Our median HZ dust level would not be a major limitation to the direct imaging search for Earth-like exoplanets, but more precise constraints are still required, in particular to evaluate the impact of exozodiacal dust for the spectroscopic characterization of imaged exo-Earth candidates.
The Hunt for Observable Signatures of Terrestrial Systems survey searches for dust near the habitable zones (HZs) around nearby, bright main-sequence stars. We use nulling interferometry in the N ...band to suppress the bright stellar light and to probe for low levels of HZ dust around the 30 stars observed so far. Our overall detection rate is 18%, including four new detections, among which are the first three around Sun-like stars and the first two around stars without any previously known circumstellar dust. The inferred occurrence rates are comparable for early-type and Sun-like stars, but decrease from % for stars with previously detected cold dust to % for stars without such excess, confirming earlier results at higher sensitivity. For completed observations on individual stars, our sensitivity is five to ten times better than previous results. Assuming a lognormal excess luminosity function, we put upper limits on the median HZ dust level of 13 zodis (95% confidence) for a sample of stars without cold dust and of 26 zodis when focusing on Sun-like stars without cold dust. However, our data suggest that a more complex luminosity function may be more appropriate. For stars without detectable Large Binocular Telescope Interferometer (LBTI) excess, our upper limits are almost reduced by a factor of two, demonstrating the strength of LBTI target vetting for future exo-Earth imaging missions. Our statistics are limited so far, and extending the survey is critical to informing the design of future exo-Earth imaging surveys.
Abstract
We present near-infrared Large Binocular Telescope LMIRCam imagery of the disk around the Herbig Ae/Be star AB Aurigae. A comparison of the surface brightness at
K
s
(2.16
μ
m), H
2
O ...narrowband (3.08
μ
m), and
L
′
(3.7
μ
m) allows us to probe the presence of icy grains in this (pre)transitional disk environment. By applying reference differential imaging point-spread function subtraction, we detect the disk at high signal-to-noise ratios in all three bands. We find strong morphological differences between the bands, including asymmetries consistent with the observed spiral arms within 100 au in
L
′
. An apparent deficit of scattered light at 3.08
μ
m relative to the bracketing wavelengths (
K
s
and
L
′
) is evocative of ice absorption at the disk surface layer. However, the Δ(
K
s
− H
2
O) color is consistent with grains with little to no ice (0%–5% by mass). The
Δ
(
H
2
O
−
L
′
)
color, conversely, suggests grains with a much higher ice mass fraction (∼0.68), and the two colors cannot be reconciled under a single grain population model. Additionally, we find that the extremely red
Δ
(
K
s
−
L
′
)
disk color cannot be reproduced under conventional scattered light modeling with any combination of grain parameters or reasonable local extinction values. We hypothesize that the scattering surfaces at the three wavelengths are not colocated, and that the optical depth effects in each wavelength result from probing the grain population at different disk surface depths. The morphological similarity between
K
s
and H
2
O suggests that their scattering surfaces are near one another, lending credence to the Δ(
K
s
− H
2
O) disk color constraint of <5% ice mass fraction for the outermost scattering disk layer.
Abstract
The young (50–400 Myr) A3V star
β
Leo is a primary target to study the formation history and evolution of extrasolar planetary systems as one of the few stars with known hot (∼1600 K), warm ...(∼600 K), and cold (∼120 K) dust belt components. In this paper, we present deep mid-infrared measurements of the warm dust brightness obtained with the Large Binocular Telescope Interferometer (LBTI) as part of its exozodiacal dust survey (HOSTS). The measured excess is 0.47% ± 0.050% within the central 1.5 au, rising to 0.81% ± 0.026% within 4.5 au, outside the habitable zone of
β
Leo. This dust level is 50 ± 10 times greater than in the solar system’s zodiacal cloud. Poynting–Robertson drag on the cold dust detected by Spitzer, and Herschel underpredicts the dust present in the habitable zone of
β
Leo, suggesting an additional delivery mechanism (e.g., comets) or an additional belt at ∼5.5 au. A model of these dust components is provided that implies the absence of planets more than a few Saturn masses between ∼5 au and the outer belt at ∼40 au. We also observationally constrain giant planets with the LBTI imaging channel at 3.8
μ
m wavelength. Assuming an age of 50 Myr, any planet in the system between approximately 5–50 au must be less than a few Jupiter masses, consistent with our dust model. Taken together, these observations showcase the deep contrasts and detection capabilities attainable by the LBTI for both warm exozodiacal dust and giant exoplanets in or near the habitable zone of nearby stars.
The salinity gradient separating marine and freshwater environments represents a major ecological divide for microbiota, yet the mechanisms by which marine microbes have adapted to and ultimately ...diversified in freshwater environments are poorly understood. Here, we take advantage of a natural evolutionary experiment: the colonization of the brackish Baltic Sea by the ancestrally marine diatom Skeletonema marinoi. To understand how diatoms respond to low salinity, we characterized transcriptomic responses of acclimated S. marinoi grown in a common garden. Our experiment included eight strains from source populations spanning the Baltic Sea salinity cline. Gene expression analysis revealed that low salinities induced changes in the cellular metabolism of S. marinoi, including upregulation of photosynthesis and storage compound biosynthesis, increased nutrient demand, and a complex response to oxidative stress. However, the strain effect overshadowed the salinity effect, as strains differed significantly in their response, both regarding the strength and the strategy (direction of gene expression) of their response. The high degree of intraspecific variation in gene expression observed here highlights an important but often overlooked source of biological variation associated with how diatoms respond to environmental change.
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Healthcare reform is upon the United States (US) healthcare system. Prioritisation of preventative efforts will guide necessary transitions within the US healthcare system. While annual deep-vein ...thrombosis (DVT) costs have recently been defined at the US national level, annual pulmonary embolism (PE) and venous thromboembolism (VTE) costs have not yet been defined. A decision tree and cost model were developed to estimate US health care costs for total PE, total hospital-acquired PE, and total hospital-acquired “preventable” PE. The previously published DVT cost model was modified, updated and combined with the PE cost model to elucidate the same three categories of costs for VTE. Direct and indirect costs were also delineated. For VTE in the base model, annual cost ranges in 2011 US dollars for total, hospital- acquired, and hospital-acquired “preventable” costs and were $13.5-$27.2, $9.0-$18.2, and $4.5-$14.2 billion, respectively. The first sensitivity analysis, with higher incidence rates and costs, demonstrated annual US total, hospital-acquired, and hospital-acquired “preventable” VTE costs ranging from $32.1-$69.3, $23.7-$51.5, and $11.9-$39.3 billion, respectively. The second sensitivity analysis with long-term attack rates (LTAR) for recurrent events and post-thrombotic syndrome and chronic pulmonary thromboembolic hypertension demonstrated annual US total, hospital-acquired, and hospital-acquired “preventable” VTE costs ranging from $15.4-$34.4, $10.3-$25.4, and $5.1-$19.1 billion, respectively. PE costs comprised a majority of the VTE costs. Prioritisation of effective VTE preventative strategies will reduce significant costs, morbidity and mortality within the US healthcare system. The cost models may be utilised to estimate other countries’ costs or VTE-specific disease states.
Lotmaria passim Schwarz (Trypanosomatidae) is a recently described trypanosome parasite of honey bees in the continental United States, Europe, and Japan. We developed a multiplex PCR technique using ...PCR primers specific for L. passim or Crithidia species to distinguish L. passim from C. mellificae Langridge and McGhee. We report the presence of L. passim in Hawaii and American Samoa for the first time. More importantly, this multiplex PCR will be a useful diagnostic technique for screening honey bee samples for the presence of this pathogenic trypanosome.
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